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Dendritic Cell Subset Identified in Celiac Disease
Jefferson Adams is a freelance writer living in San Francisco. His poems, essays and photographs have appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, Huffington Post, the Mississippi Review, and Slate among others.
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A team led by Dr. Melinda Raki set out to compare the antigen-presenting cells in the small intestine of patients with celiac disease versus those from normal individuals.
Antigen presenting cells are so termed because they present gluten to the T-cells, which then contribute to the inflammation that damages the villi in the intestinal lining of those with celiac disease.
Researcher found that in the normal duodenal mucosa, about 20% of the HLA-DQ2 molecules associated with celiac disease were Cd11c+ dendritic cells. These dendritic cells accrued in the celiac lesions of the untreated celiac subjects.
When these CD11c+ cells were removed from the biopsy samples, they provoked an adverse gluten reaction in the T-cells.
The study indicates that a greater knowledge of antigen-presenting cells will yield a more complete understanding of the dynamics of celiac disease, the means by which inflammation occurs, and the means by which it can be controlled or avoided altogether.
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