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Gluten-Sensitive Enteropathy
- By Scott Adams
- Published 07/26/1996
- Celiac Disease & Gluten Intolerance Research
- Unrated
Scott Adams
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease, and since then it has become an invaluable resource to people worldwide who seek information about celiac disease and the gluten-free diet.
In 1998 I created The Gluten-Free Mall, Your Special Diet Superstore! which was also another Internet first—it was the first gluten-free food site to offer a shopping cart-style interface, and the ability for people to order gluten-free products manufactured by many different companies at a single Web site.
I am also co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.
Author: Troncone R; Greco L;
Auricchio S
Address: Department of Pediatrics, University Federico II, Naples,
Italy.
Source: Pediatr Clin North Am, 43: 2, 1996 Apr, 355-73
Abstract:
Gluten-sensitive enteropathy is induced by dietary wheat gliadin
and related proteins in genetically susceptible individuals.
Most evidence suggests that the mucosal lesion represents an
immunologically mediated injury triggered by gluten in the context
of a particular assortment of major histocompatibility complex
genes. The amino acid residues of gliadin and related proteins
responsible for toxicity have not been identified; in vitro
systems are available, but definitive conclusions must rely
on in vivo jejunal challenges. At a conservative estimate, symptomatic
gluten-sensitive enteropathy affects approximately 1 in 1000
individuals in Europe; however, it is now becoming clear that
a greater proportion of individuals has clinically silent disease,
and probably many others have a minor form of the the enteropathy.
In most countries, the clinical presentation has changed over
the past few years coming closer to the adult type of the disease,
and the age of onset of symptoms is shifting upward. Liver,
joint, hematologic, dental, and neurological symptoms are increasingly
being recognized. Several diseases are associated the gluten-sensitive
enteropathy, such as IgA deficiency, insulin-dependent diabetes
mellitus, and a range of other autoimmune diseases. Tests based
on the measurement of antigliadin and antiendomysium antibodies
have gained success as noninvasive screening tests; however,
the ultimate diagnosis still is based on the finding of a severe
histologic lesion of the jejunum while the patient is on a gluten-containing
diet and on its disappearance once the gluten is excluded from
the diet. A lifelong, strict gluten-free diet is mandatory for
celiac children. Among other long-term problems, an increased
risk of intestinal lymphoma has been reported in patients on
a normal gluten-containing diet.
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