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The Celiac Disease - Depression Connection
- By Jefferson Adams
- Published 03/15/2008
- Depression and Celiac Disease
-
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Jefferson Adams
Jefferson Adams is a freelance writer living in San Francisco. His poems and essays have appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, and The Mississippi Review, among others.
View all articles by Jefferson AdamsThe Celiac Disease - Depression Connection
Celiac.com 03/15/2008 - For the first time, medical researchers have shown that an activation of the inflammatory response system accompanies major depression and that pro-inflammatory cytokines and lipopolysaccharide (LPS) may trigger symptoms of depression. In the face of the study results, researchers are recommending that patients with depression be screened for leaky gut using IgM and IgA panels.
Researchers set out to determine the role played by increased gastrointestinal permeability coupled with an increased translocation of LPS from gram-negative bacteria in the pathophysiology of major depression (MDD). The researcher team was made up of M. Maes, M. Kubera, J.C. Leunis. The team created a study to evaluate serum levels of IgM and IgA against LPS of the gram-negative enterobacteria Hafnia Alvei, Pseudomonas Aeruginosa, Morganella Morganii, Pseudomonas Putida, Citrobacter Koseri, and Klebsielle Pneumoniae in MDD patients and normal controls.
Compared to the non-depressive control groups, patients with major depression (MDD) showed significantly greater prevalences and median values for serum IgM and IgA against LPS of enterobacteria. Increased levels of IgM and IgA are associated with fatigue, autonomic and gastro-intestinal symptoms and a subjective feeling of infection.
Leaky Gut a Factor in Major Depression
The results demonstrate that intestinal mucosal dysfunction marked by an elevated translocation of gram-negative bacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.
Researchers are suggesting that IgM and IgA panels be used to screen people who suffer from depression for leaky gut.
Neuro Endocrinol Lett. 2008 Feb;29(1):117-24.
Researchers set out to determine the role played by increased gastrointestinal permeability coupled with an increased translocation of LPS from gram-negative bacteria in the pathophysiology of major depression (MDD). The researcher team was made up of M. Maes, M. Kubera, J.C. Leunis. The team created a study to evaluate serum levels of IgM and IgA against LPS of the gram-negative enterobacteria Hafnia Alvei, Pseudomonas Aeruginosa, Morganella Morganii, Pseudomonas Putida, Citrobacter Koseri, and Klebsielle Pneumoniae in MDD patients and normal controls.
Compared to the non-depressive control groups, patients with major depression (MDD) showed significantly greater prevalences and median values for serum IgM and IgA against LPS of enterobacteria. Increased levels of IgM and IgA are associated with fatigue, autonomic and gastro-intestinal symptoms and a subjective feeling of infection.
Leaky Gut a Factor in Major Depression
The results demonstrate that intestinal mucosal dysfunction marked by an elevated translocation of gram-negative bacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.
Researchers are suggesting that IgM and IgA panels be used to screen people who suffer from depression for leaky gut.
Neuro Endocrinol Lett. 2008 Feb;29(1):117-24.
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Comments
#1 ( Joseph)
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This is a great article.
#2 ( Carla)
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Would it be advisable then, that all people suffering from major depression be put on strict gluten free diets? Perhaps even in the mental hospitals, it may be helpful to observe gluten free diets for those with bloated abdomens.