- Celiac Disease Research: Associated Diseases and Disorders
- Depression and Celiac Disease
- The Celiac Disease - Depression Connection
The Celiac Disease - Depression Connection
Jefferson Adams is a freelance writer living in San Francisco. His poems, essays and photographs have appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, Huffington Post, the Mississippi Review, and Slate among others.View all articles by Jefferson Adams
Researchers set out to determine the role played by increased gastrointestinal permeability coupled with an increased translocation of LPS from gram-negative bacteria in the pathophysiology of major depression (MDD). The researcher team was made up of M. Maes, M. Kubera, J.C. Leunis. The team created a study to evaluate serum levels of IgM and IgA against LPS of the gram-negative enterobacteria Hafnia Alvei, Pseudomonas Aeruginosa, Morganella Morganii, Pseudomonas Putida, Citrobacter Koseri, and Klebsielle Pneumoniae in MDD patients and normal controls.
Compared to the non-depressive control groups, patients with major depression (MDD) showed significantly greater prevalences and median values for serum IgM and IgA against LPS of enterobacteria. Increased levels of IgM and IgA are associated with fatigue, autonomic and gastro-intestinal symptoms and a subjective feeling of infection.
Leaky Gut a Factor in Major Depression
The results demonstrate that intestinal mucosal dysfunction marked by an elevated translocation of gram-negative bacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.
Researchers are suggesting that IgM and IgA panels be used to screen people who suffer from depression for leaky gut.
Neuro Endocrinol Lett. 2008 Feb;29(1):117-24.
As always, Celiac.com welcomes your comments (see below).
Get FREE Celiac.com email alerts (1-3 email per month with the latest celiac disease research and information, gluten-free recipes, etc.).