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    Jefferson Adams
    Jefferson Adams

    Late Diagnosis of Celiac Disease Increases Risk of Sepsis

    Reviewed and edited by a celiac disease expert.

    Celiac.com 09/22/2008 - People diagnosed with celiac disease in adulthood face a slightly higher risk of developing a severe infection called pneumococcal sepsis, according to the results of a study published in the August issue of the journal Gut.

    A Swedish research team led by Dr. Jonas F. Ludvigsson, of Orebro University Hospital, Sweden reviewed data gathered from the Swedish National Inpatient Register to assess the risk faced by people with celiac disease of developing sepsis. The researchers looked at 15,325 patients with a diagnosis of celiac disease, 14,494 inpatient reference subjects, and as many as five reference individuals per case from the general population.

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    People diagnosed with celiac disease as adults developed sepsis at slightly higher levels than inpatient reference patients (HR = 1.5, p = 0.006). The elevated risk for sepsis was also seen when celiac disease patients were compared with reference subjects from the general population (HR = 2.6, p < 0.001). Celiac disease patients diagnosed in childhood showed a slightly elevated increased risk of sepsis when compared to the general population (HR = 1.8, p = 0.003).

    According to Dr. Ludvigsson’s team, this elevated risk of developing pneumococcal sepsis faced by people with celiac disease might be due to a condition called hyposplenism, but the study’s small size, and it’s lack of data on spleen size made it impossible to make a firm conclusion as to the cause.

    Gut 2008;57:1074-1080.


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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


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