Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Where Your Contribution Counts!
    eNewsletter
    Support Us!
  • Record is Archived

    This article is now archived and is closed to further replies.

    Diana Gitig Ph.D.
    Diana Gitig Ph.D.

    Gluten Can Cause GI Symptoms in People Who Don't Have Celiac

    Reviewed and edited by a celiac disease expert.
    Gluten Can Cause GI Symptoms in People Who Don't Have Celiac -

    This article originally appeared in the Spring 2011 edition of Celiac.com's Open Original Shared Link.

    Celiac.com 06/22/2011 - Gluten intolerance among people who do not have celiac disease seems to be an increasing reality, yet scientists have not been able to find any evidence explaining it. A team of researchers in Australia noted that the question of whether gluten can contribute to gastrointestinal symptoms and/ or induce injury to the proximal small intestine had never been directly assessed. So, they set out to assess it. Their results are published in the January 11, 2011 issue of The American Journal of Gastroenterology. They conclude that “non-celiac gluten intolerance” may in fact exist, although they were unable to discern the potential mechanism.

    Celiac.com Sponsor (A12):
    Their study population consisted of patients with irritable bowel syndrome (IBS) whose symptoms were alleviated by the elimination of gluten from their diet and who definitely did not have celiac disease, as determined by the absence of the HLA-DQ2 or HLA-DQ8 haplotypes. If patients did express these haplotypes, celiac disease was excluded by a normal duodenal biopsy while they were on a gluten containing diet. Unfortunately the authors could only find 34 patients who met these criteria, but they maintain that they could still infer a statistically robust result from their data. Participants had to have been on a gluten free diet for at least six weeks at the beginning of the study. At that point, they were given a study muffin and two slices of study bread to eat every day for six weeks. These goods were baked from gluten free mixes in a gluten free facility, but half of them had gluten added. Importantly, it was only gluten, not wheat; the carbohydrates found in wheat, which are known to elicit GI symptoms, were not included. The study was randomized, double-blind, and placebo controlled, so neither the researchers nor the participants knew who was eating the gluten.

    After only one week, 68% of the patients eating gluten reported more severe pain, bloating, and tiredness, and less satisfaction with their stool consistency, than the cohort who got the gluten free study muffins and bread. This remained the case over the course of the six week study; six patients eating gluten even had to withdraw from the study after the first week because their symptoms got too bad. There did not seem to be much difference between the two groups in what the authors deemed the “less relevant” symptom of nausea. Interestingly, the symptom most exacerbated by gluten was tiredness. Since tiredness is a common symptom of IBS, its induction by gluten may shed some light into a mechanism of action.

    Neither treatment group showed any changes from baseline in assayed biomarkers. These included celiac antibodies; fecal lactoferrin, which increases during intestinal inflammation; C-reactive protein, a sensitive marker for the systemic circulation of cytokines; and intestinal permeability. The authors suggest that perhaps their assays were not sensitive enough to detect subtle molecular changes. About half of the study participants were positive for the HLA-DQ2/8 haplotype, but there were no differences between those who were and those who were negative, either in gluten’s effect on their symptoms or in their biomarkers.

    This study is significant as the first demonstration that gluten may trigger gut symptoms in people who don’t have celiac disease. Subsequent work should elucidate how exactly it does so, but in the meantime, these findings have valuable clinical implications – perhaps more people with GI symptoms will be put on a gluten free diet.

    Source:

    • Open Original Shared Link



    User Feedback

    Recommended Comments

    Guest Nancy

    Posted

    This is my daughter. She has no clinical findings, but gets symptoms within 30 minutes of eating any gluten.

    Link to comment
    Share on other sites
    Guest barbara

    Posted

    Good article...article in my newspaper with same info today.

    Link to comment
    Share on other sites
    Guest frazer edwards

    Posted

    All one can say to such a finding are DUH! Ask any practicing Naturopathic clinician whether their patients feel better after a gluten-free diet and get the very common answer: MORE THAN 50%. When standard Western medicine begins to understand this there may be better outcomes for people with IBS, Crohn's disease and a myriad of other symptoms, on a gluten and grain free diet perhaps ... nah never happen because of the agriculture lobby.

    Link to comment
    Share on other sites
    Guest David

    Posted

    Very Interesting. I am non-celiac GI. It has been a little frustrating that the mechanism is unknown. My sensitivity has greatly increased over time. Understanding why it happens would get us that much closer to a cure or at least better ways to control it. God's speed on more research. By the way, it is definitely for real. I had fairly severe IBS symptoms till I was 43 and a doctor suggested that I eliminate gluten based on an IGG test. I was fully recovered within 4 days on a gluten free diet. Felt great for about a year and a half, but have had to tighten my gluten free diet more and more to stay well. It would be great to understand why this is happening. Genetic testing eliminated the possibility of celiac.

    Link to comment
    Share on other sites
    Guest Betty J. Owen

    Posted

    Very timely and well done. Appreciate the information! Look forward to further research results.

    Link to comment
    Share on other sites
    Guest andrew falzon

    Posted

    Very interesting.

    Link to comment
    Share on other sites
    Guest Veronic aTurner

    Posted

    This article was very informative. The study was sound and not biased. I became really ill around 3 years ago. My symptoms had been developing over a long period. Eventually, after a myriad of tests I was put on a wheat-free, gluten-free diet. Within one month my symptoms had pretty much settled and now 3 years later I am so much better. So long as no wheat or gluten enters my diet. Occasionally I accidentally get exposed and I become sick very quickly. I have non-celiac gluten intolerance with wheat allergy.

    Link to comment
    Share on other sites
    Guest janet

    just realizing what gluten is doing to me waiting for gluten test to determine if I have gluten intolerance. I have gone on a gluten-free diet and feel much better. I have had bowel issues all my life and now at 65, my symptoms are worse.

    Link to comment
    Share on other sites


    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Help Celiac.com:
    Donate
  • About Me

    Diana Gitig Ph.D.

    Diana received her B.A. in Biochemistry from the University of Pennsylvania, and then a Ph.D. in Cell Biology and Genetics from Cornell. Now she is a freelance science writer and editor in White Plains, New York.  Her son was diagnosed with celiac disease in 2006, at the age of five, and she has been keeping her family healthy by feeding them gluten free treats ever since.


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Celiac.com 03/26/2007 - According to a recent Norwegian research report, the adverse immune response to gluten may be tied to a specific set of dendrite cells in the small intestine.
    A team led by Dr. Melinda Raki set out to compare the antigen-presenting cells in the small intestine of patients with celiac disease versus those from normal individuals.
    The study used multiple duodenal biopsy specimens from 14 patients with untreated celiac disease, 6 with treated celiac disease and 4 controls.
    Antigen presenting cells are so termed because they present gluten to the T-cells, which then contribute to the inflammation that damages the villi in the intestinal lining of those with celiac disease.
    Researcher found that in the normal duodenal mucosa, about 20% of the...


    Kathleen La Point
    Celiac.com 04/28/2008 - A life-long gluten-free diet is currently the only treatment for celiac disease. However, many foods thought to be gluten-free actually contain small amounts of gluten, making it difficult to maintain a truly gluten-free diet.
    Gluten is made up of glutenin and gliadin proteins. Gliadin is only partially digested in the small intestine and the resulting peptides are responsible for the inflammation and intestinal tissue damage in people with celiac disease. Because probiotic bacteria have been shown to digest gluten proteins to harmless peptides, supplementation with probiotics may be beneficial for people with celiac disease.
    To begin testing this hypothesis, researchers in Finland added probiotic bacteria to cultures of intestinal epithelial cells (cells ...


    Jefferson Adams
    Celiac.com 04/23/2009 - Celiac disease is far more common among people of European descent, especially northern European descent, than among other populations. In East Asia, including China, there have been only sporadic reports of celiac disease. Historically, celiac disease has been only rarely reported in Asia.
    Due to the absence of reports, and since Asian diets are traditionally low in wheat, barley or rye, it has been taken as a given that Asian populations don't really suffer from celiac disease. Still, there have been no comprehensive studies undertaken to verify this notion.
    Recently, a team of Chinese researchers set out to put that assumption to the test, and to determine if Open Original Shared Link.
    The team was made up of L. L. Jiang, B.L. Zhang, and Y.S. Liu....


    Jefferson Adams
    Celiac.com 02/04/2015 - For kids with a predisposition to celiac disease, does the age at which they first eat gluten have any connection with their risk for celiac disease? A team of researchers wanted to figure out whether the age at which a child first eats gluten carried any associated with risk for celiac disease, for genetically predisposed children. The Environmental Determinants of Diabetes in the Young (TEDDY) is a prospective birth cohort study.
    The research team included Carin Andrén Aronsson, MSca, Hye-Seung Lee, PhD, Edwin Liu, MD, PhD, Ulla Uusitalo, PhD, Sandra Hummel, PhD, Jimin Yang, PhD, RD, Michael Hummel, MD, PhD, Marian Rewers, MD, PhD, Jin-Xiong She, PhD, Olli Simell, MD, PhD, Jorma Toppari, MD, PhD, Anette-G. Ziegler, MD, PhD, Jeffrey Krischer, PhD, Suvi M. Virtanen,...


  • Recent Activity

    1. - trents replied to JustGemi's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      8

      SCARED: What Do These Test Results Mean?

    2. - Scott Adams replied to Kaylee G's topic in Gluten-Free Recipes & Cooking Tips
      1

      Learning to cook for myself

    3. - JustGemi replied to JustGemi's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      8

      SCARED: What Do These Test Results Mean?

    4. - Scott Adams replied to Raquel2021's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      1

      Went to see a gastroenterologist today and


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      120,475
    • Most Online (within 30 mins)
      7,748

    Tina McClendon
    Newest Member
    Tina McClendon
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.2k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • JustGemi
    • Linedancegal
    • Hannah24
      9
    • jessiemariecar
    • Rhonda H
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...