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    Jefferson Adams
    Jefferson Adams

    Slightly Higher Tuberculosis Risk for People with Celiac Disease

    Reviewed and edited by a celiac disease expert.
    Slightly Higher Tuberculosis Risk for People with Celiac Disease - Photo: CC - Aidan_Jones
    Caption: Photo: CC - Aidan_Jones

    Celiac.com 10/17/2011 - Some research has shown celiac disease to be associated with higher rates of tuberculosis (TB), but study results have been inconclusive due to small sample sizes. A team of researchers studied a larger population to get a better look at the relationship between celiac disease and TB. The study team included J. F. Ludvigsson, D. S. Sanders, M. Maeurer, J. Jonsson, J. Grunewald, and J. Wahlström. They are affiliated with the Department of Paediatrics at Örebro University Hospital in Örebro, Sweden.

    Photo: CC - Aidan_JonesThe team gathered biopsy data from all 28 pathology departments in Sweden. They then used the data to identify individuals who were diagnosed with celiac disease between 1969 and 2007. The included only individuals who showed Marsh 3 villous atrophy.  Their group included a total of 29,026 individuals. They then selected a group of sex- and age-matched control subjects were selected from the Total Population Register. They used Cox regression Cox to calculate hazard ratios (HRs) for TB from data in the Swedish national health registers.

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    They found that people with celiac disease faced a slightly increased TB risk (HR=2.0; 95% CI=1.3-3.0). For people with celiac disease, the absolute risk of contracting TB was 10/100,000 person-years, with an excess risk of 5/100,000. Risk estimates were the highest in the first year.

    When the team restricted its focus to TB confirmed by (I) a record of TB medication (HR=2.9; 95% CI=1.0-8.3), (II) data in the National Surveillance System for Infectious Diseases in Sweden (HR=2.6; 95% CI=1.3-5.2) or (III) positive TB cultivation (HR=3.3; 95% CI=1.6-6.8) they saw increased risk levels.

    The team also noted the positive association between celiac disease and TB prior to celiac disease diagnosis (odds ratio=1.6; 95% CI=1.2-2.1).

    In the end, the team was able to confirm a slightly higher TB risk for people with celiac disease.

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    Guest Jane

    This is interesting because my sister has celiac and I have hemochromatosis. I have the 2 genes but she has the 1 gene. Apparently Cys282 is supposed to help protect against TB. I also have gluten intolerance and feel way better having chosen not to eat gluten.

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


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    Celiac.com 03/07/2007 - A recent study conducted in Sweden shows that individuals with celiac disease apparently face a significantly greater risk of contracting tuberculosis, possibly due to mal-absorption of vitamin D, according to a report in the January 2007 issue of Thorax. Researchers found that people with prior tuberculosis are 2.5 times more likely to get celiac disease than those with no prior tuberculosis. According to lead investigator, Dr. Jonas F. Ludvigsson, of Orebro University Hospital, this indicates that celiac disease is fairly common in individuals who have tuberculosis. It also appears that tuberculosis is in fact more common in those with celiac disease than in those without.
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