No popular authors found.

Categories

No categories found.


Join Celiac.com's forum / message board and get your questions answered! Our forum has nearly 1 MILLION POSTS, and over 62,000 MEMBERS just waiting to help you with any questions about celiac disease and the gluten-free diet. We'll see you there!






Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus RSS Podcast Email  Get Email Alerts

SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Bio-physical Characteristics of Gastrointestinal Mucosa of Celiac Patients: Comparison with Control Subjects and Effect of Gluten-Free Diet

Celiac.com 11/28/2011 - Celiac disease often results in "leaky" intestinal mucosa. This development may involve changes in hydrophobicity of the mucus surface barrier along with changes of the epithelial barrier.

A team of researchers recently compared bio-physical aspects of gastrointestinal mucosa of celiac patients with control subjects, along with the effects of gluten free diet on each group.

Photo: CC -- spec-ta-clesThe research team included Stefania Bertolazzi, Francesco Lanzarotto, Barbara Zanini, Chiara Ricci, Vincenzo Villanacci, and Alberto Lanzini.

The team set out to compare duodenal hydrophobicity as an index of mucus barrier integrity in 38 patients studied before and 68 patients during gluten-free diet, and in 90 control subjects. They also checked for regional differences of hydrophobicity in the gastro-intestinal tract.

The team gauged hydrophobicity by measuring the contact angle (CA) (Rame Hart 100/10 goniometer) created by a single drop of water applied to intestinal mucosal biopsies.

Once the team pooled the results and evaluated the control groups, patients with histologically normal duodenal biopsies showed significantly higher CA (620 + 90)  than patients with biopsies showing Marsh 1-2 (580 + 100; p<0.02) and Marsh 3 lesions (570+ 100; p<0.02).

Among the control group, the action sequence of hydrofobicity along the gastrointestinal tract follows the pattern: gastric antrum> corpus> rectum> duodenum> oesophagus> ileum.

From these results, the team concludes that people with celiac disease experience reduced hydrophobicity of duodenal mucous layer, and a reduced ability to repel luminal contents. This may may contribute to the increased intestinal permeability seen in celiac disease.

This change in hydrofobicity corresponds to the severity of the mucosal lesions in the patient, and is not completely reversed by gluten-free diet.

Source:

Celiac.com welcomes your comments below (registration is NOT required).



Related Articles




Spread The Word





9 Responses:

 
Allen G. Reiter
Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
28 Nov 2011 7:31:59 AM PST
It would be helpful for this article to be written in layman's terms. I doubt that most readers will understand its point.

 
lAURA
Rating: ratingfullratingfullratingemptyratingemptyratingempty Unrated
said this on
15 Jan 2012 8:34:34 AM PST
I agree. What the heck is it telling us?

 
dot
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
28 Nov 2011 9:13:56 PM PST
I get it, but what do I do about it?

 
Laurie Massey
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
05 Dec 2011 6:11:21 AM PST
My sentiments exactly!!! What are we to do about permeability and malabsorption issues???

 
Jane
Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
05 Dec 2011 6:57:24 AM PST
I agree. Layman's terms. Had to look up a number of words.....takes a great deal of time in this busy world.

 
admin
( Author)
said this on
06 Dec 2011 4:17:37 PM PST
We do our best to update our glossary...note that you can click on many of the terms to get a definition.

 
Gloria Brown
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
05 Dec 2011 10:47:31 AM PST
For celiacs gluten can irreversibly damage the intestinal lining, so that its contents "leak" into the rest of the body, a set-up for eventual major disease. At the moment, eating fresh food only and keeping one's environment gluten-free, are one's best defense.

 
Robena
Rating: ratingfullratingfullratingemptyratingemptyratingempty Unrated
said this on
05 Dec 2011 1:33:21 PM PST
I totally agree with Dot. I get it because I live with it, but how do I get rid of it?

 
Suzanne
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
05 Dec 2011 10:45:28 PM PST
I understand that they are saying that we who are gluten-intolerant are not able to form a protective layer to keep the contents of our intestines inside (so some leaks out into the bloodstream). What do they mean, however, by that not being resolved by a gluten-free diet? Never? Do we always have a leaky gut? (I have heard that another gut gate-keeper that allows permeability, called Zonulin, also remains elevated in celiac disease--sounds like we're doomed!)




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *: