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Is Epitope-Specific Immunotherapy for Celiac Disease a Foundation for Future Autoimmune Vaccines?

Celiac.com 06/19/2013 - Currently, immunosuppressant drugs are the only real treatment option for most autoimmune disorders, such as celiac disease and Type 1 diabetes.

Photo: CC--@alviseniHowever, researchers are busily exploring the possibilities offered therapeutic vaccines, known as antigen-specific immunotherapy. ImmusanT is one company working to develop a vaccine that will allow patients with celiac disease to safely eat gluten (the antigen). That vaccine is presently undergoing clinical trials.

ImmusanT and its research partners are looking to build on their expertise in celiac disease to improve their understanding of antigen-specific immunotherapy for other autoimmune diseases.

In Current Opinion in Immunology, researchers Bob Anderson and Bana Jabri describe how identification of pathogenic T cell epitopes (segment of the antigen) and recent initiatives to optimize immune monitoring have helped drive rational vaccine design in human autoimmune diseases.

Celiac disease has provided researchers with the first opportunity to design and test epitope-specific immunotherapy with a thorough understanding of disease-causing T cell epitopes.

This approach offers "truly customized immunotherapy for patients with celiac disease according to their genetics and the molecular specificity of their immune response to gluten," said Bob Anderson, PhD, MBChB, Chief Scientific Officer of ImmusanT.

Because celiac disease shares key features, such as susceptibility genes, presence of autoantibodies and destruction of specific cells, with other autoimmune disorders, like Type 1 diabetes and rheumatoid arthritis, it provides a model for understanding and exploring the triggers and drivers of autoimmunity, in general, write Drs. Bana Jabri and Ludvig Sollid in the Perspectives section in Nature Reviews Immunology.

By factoring in the association with the major histocompatibility complex (MHC), post-translation modifications, the antigen and the tissue, researchers can design methods that help to the spot potential drivers of autoimmune disease.

Because peptide-specific therapy specifically targets the immune cells that drive the disease process, "it offers the potential to prevent and cure disease, without inducing general immunosuppression," said Bana Jabri, MD, PhD, Director, University of Chicago Celiac Center; Professor, Department of Medicine, Pathology and Pediatrics, University of Chicago; and Senior Scientific Advisor to ImmusanT.

Ludvig M. Sollid, MD, PhD, is Director, Centre for Immune Regulation; Professor of Medicine, Department of Immunology, University of Oslo; Consultant, Oslo University Hospital-Rikshospitalet; and member of ImmusanT's Scientific Advisory Board.

Dr. Jabri is Co-Chair of the 15(th) International Celiac Disease Symposium to be hosted by the University of Chicago Celiac Disease Center, September 22-25, 2013.

The event will draw the world's top scientists and physicians to discuss the most recent scientific advances in managing and treating celiac disease and gluten-related disorders.

 

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9 Responses:

 
Melinda Jepson
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said this on
20 Jun 2013 4:32:18 AM PST
This is good news for us gluten-free people.

 
CeliacDiseaseCtr
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said this on
20 Jun 2013 11:08:26 AM PST
Both of these doctors will be at the International Celiac Disease Symposium discussing their progress toward a cure... join us there, as the ICDS is a unique opportunity to have your questions answered about treating and curing gluten-related disorders!

 
Joan
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said this on
20 Jun 2013 5:17:46 PM PST
Good news for GLUTEN-free persons and if it really works for the person. How long before it is ready to sell and how much will it cost?

 
Ken Olson
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said this on
20 Jun 2013 8:14:35 PM PST
Sounds interesting. What is the cost of the Symposium?

 
Mark Bogdany
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said this on
25 Jun 2013 11:24:27 AM PST
Look forward to learning about more research like this!

 
Adrienne
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said this on
26 Jun 2013 6:01:43 AM PST
I am hopeful.

 
Amir
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said this on
27 Jun 2013 2:22:16 PM PST
By suppressing immune systems, I hope the body of celiac person would not susceptible to other diseases or the immune system would not malfunction.

 
annaya
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said this on
28 Jun 2013 8:19:06 AM PST
When will it be available???

 
Rhonda
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said this on
30 Jun 2013 3:00:23 PM PST
Good article. Even if the vaccine works, I will never knowingly eat gluten again. There is a reason it is so bad for us, and in general, all processed foods and GMOs are the real problem. However, it would be nice not to have the horrible results of inadvertently and unknowingly eating gluten.




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