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Molecule May Enable New Treatments for Celiac Disease
Jefferson Adams is a freelance writer living in San Francisco. His poems, essays and photographs have appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, Huffington Post, the Mississippi Review, and Slate among others.
He is a member of both the National Writers Union, the International Federation of Journalists, and covers San Francisco Health News for Examiner.com.View all articles by Jefferson Adams
Celiac.com 05/14/2014 - A team of Canadian researchers have discovered a key molecule that could lead to new treatments for celiac disease. The molecule, called elafin, protects the lining of the intestine, says Elena Verdu, associate professor of medicine, and head of the McMaster University research team.
When people with celiac disease consume gluten, tiny proteins called gliadins cross the intestinal lining and cause inflammation. There are also other proteins in wheat grain that may contribute to the common complaint of abdominal pain, such as ATIs which help grains be resistant to pests.
Low levels of elafin in the intestinal lining can increase inflammation. According to Verdu, treatment with elafin could strengthen the intestinal lining, protect it from accidental gluten ingestion or contamination, and help to speed recovery.
The Canadian Institute of Health Research is providing $400,000 over four years to fund the research.
Stay tuned for more reporting on their efforts.
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Gut Bacteria Play Significant Role in Gluten Metabolism
Although the role of human digestive proteases in gluten proteins is quite well known, researchers don’t know much about the role of gut bacteria in the metabolism of these proteins.... [READ MORE]
Larazotide Acetate in Patients With Celiac Disease Undergoing a Gluten Challenge
Ever wonder what happens to all those celiac disease patients who volunteer to do a gluten-challenge in the name of science? Well, the short answer is that they likely suffer, and may incur gut damage, at least in the short term.... [READ MORE]
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Gluten-free Diet and Quality of Life in Patients with Screen-detected Celiac Disease
The following Medline abstract describes
a unique study that was done on the quality of life of two groups of people
with celiac disease: One that was diagnosed as the result of having symptoms,
and the other which had little or no symptoms and whose diagnosis was
reached via screen-detection.... [READ MORE]