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    Jefferson Adams
    Jefferson Adams

    Can Viruses Trigger Celiac Disease?

    Reviewed and edited by a celiac disease expert.

    Celiac.com 07/27/2016 - Celiac disease is an immune-based disorder triggered by an adverse immune reaction to gluten proteins in genetically susceptible people. A new study shows that certain viral diseases may increase celiac risk, and confirms a link between intestinal viral infections and celiac disease.

    Reinhard Hinterleitner earned his PhD from the Medical University of Innsbruck in Open Original Shared Link at the group of Gottfried Baier at the Open Original Shared Link. He is currently doing postdoctoral research at the Open Original Shared Link as part of an Erwin Schrödinger Fellowship.

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    Dr. Hinterleitner looked at blood samples and 150 small-intestine biopsies from celiac patients and compared them with those of a healthy control group. He found that intestinal viruses can trigger a sort of long-term false alarm in celiac patients by upsetting the small intestine and transforming regulatory T lymphocytes into pro-inflammatory T lymphocytes.

    "The dendritic cells are also alerted by the infection. If gluten...is consumed at the same time as a viral infection occurs, the already alerted dendritic cells also present gluten antigens to the T lymphocytes," said Dr. Hinterleitner.

    This can result in the transmission of incorrect information, and can trigger an inflammatory response in T lymphocytes that attacks both the virus and the gluten. They have seen as much in genetically engineered celiac mouse models, wherein a reoviral infection of the small intestine of mice triggers clinical symptoms similar to those experienced by celiac patients who consume gluten.

    This might also explain why infants who have already had a rotavirus infection are more likely to develop celiac disease. Because if an infant is suffering from a viral infection at the same time, the first intake of gluten, which is supposed to establish oral tolerance to gluten, might in fact have the opposite effect.

    If this is true, early vaccination against intestinal viruses such as rota- and reovirus in early childhood might reduce the incidence of celiac disease.

    They estimate that introducing gluten at the same time as intestinal virus infection results in a long-term loss of oral tolerance to gluten in the 20 percent of the population with the genetic predisposition for celiac disease, especially in patients who respond more strongly to virus infections.

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    Guest B. Hoerner

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    Very interesting article. At 59 I developed celiac disease. Immediately prior to having symptoms associated with celiac disease, I had what my doctors treated as a stomach virus-- one that just wouldn't go away. Fortunately it only took six months for doctors to figure out what was wrong. Within days of diet modification I was better!

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


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