Celiac.com 03/19/2002 - For the past several years, Gary M.
Gray, M.D. and Chaitan Khosla, Ph.D., both at Stanford University,
have been studying the underlying causes of Celiac Disease,
with an eye toward finding a therapeutic solution that would
not require the strict adherence to a gluten-free diet. For
the past two years, I have helped organize the Celiac conference
at Stanford University; and we have collected blood from Celiac
volunteers for their research. Based on a series of studies
involving animal tissue, Drs. Gray, Khosla, and coworkers have
developed a hypothesis for the cause of the disease. Their findings
in animal studies need to be confirmed on human tissue, and
any differences in normal and Celiac intestine must be defined.
The Stanford researchers are now in need of volunteers who are
scheduled for a follow-up biopsy as part of their optimal care
to provide intestinal tissue samples. Volunteers must be biopsy-diagnosed
Celiacs who, as part of their care, will be undergoing an upper
gastrointestinal endoscopy for recovery of small biopsies from
the duodenum. For this research, two small (a few milligrams)
of additional tissue will be taken during the biopsy, frozen
immediately, and transported to Stanford. Please note that volunteers
undergoing procedures at locations other than Stanford Hospital
could participate. The small amount of additional tissue does
not constitute a significant additional risk over and above
that you will undergo due to the endoscopy and routine biopsies
for the pathologist to examine. The research has been approved
by the Human Subjects Committee at Stanford University Medical
you would like to participate in this study, please contact Kelly
Rohlfs at 650-725-4771 or firstname.lastname@example.org.If
you have questions concerning the risks and benefits of this study,
please contact Dr. Gray at 650-725-3366 or email@example.com.
Dr. Gray will coordinate the study with your gastroenterologist
at the time of your endoscopy.