Celiac Disease & Gluten-free Diet Information at Celiac.com - http://www.celiac.com
Reaction to a Gluten Challenge
http://www.celiac.com/articles/53/1/Reaction-to-a-Gluten-Challenge/Page1.html
Scott Adams

In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease, and since then it has become an invaluable resource to people worldwide who seek information about celiac disease and the gluten-free diet.

In 1998 I created The Gluten-Free Mall, Your Special Diet Superstore! which was also another Internet first—it was the first gluten-free food site to offer a shopping cart-style interface, and the ability for people to order gluten-free products manufactured by many different companies at a single Web site.

I am also co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

 
By Scott Adams
Published on 07/26/1996
 
The following post if from Karoly Horvath, M.D., khorvath@POL.NET, who is one of the two di

The following post if from Karoly Horvath, M.D., khorvath@POL.NET, who is one of the two directors of the celiac center at University of Maryland in Baltimore.

Q: Does that mean I could be getting damage without knowing it because I have no obvious reaction?

A: Based on our studies a typical (biopsy proven flat mucosa, proved immune reactions to gluten) gluten intolerant patient does not react immediately with clinical symptoms for a gluten challenge (J Pediatr Gastroenterol Nutr 1989, 9:176-180). However, ingestion of GRAMS OF GLUTEN causes several changes in the intestine.

  • There is an accumulation of inflammatory cells
  • One cell type -so called mast cells- releases factors which factors in long-term damage the villi and they also release a factor which;
  • Increases the permeability -leakiness- of the intestine, which is a temporarily change after a single ingestion but may be permanent after repeat dietary mistakes.

Karoly Horvath, M.D., Ph.D., Baltimore