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Genetic Markers for Celiac Testing

By Vijay Kumar, PhD., IMMCO Diagnostics, Inc. - IMMTEST@AOL.COM

The genetic markers associated with celiac disease are:

  • HLA DQalpha *0501
of being HLA-identical.'); return false">HLA DQbeta *0201

More than 90% of patients with celiac disease have these markers. Negative tests for these markers in conjunction with negative serum antibody tests suggest an absence of celiac disease. However, positive tests for the genetic markers do not necessarily mean that the patient has celiac disease. In conclusion, genetic markers can be used as a test to exclude celiac disease as a diagnosis.

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