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High Percentage of Celiacs Nonresponsive to Hepatitis B Vaccine
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I foundedÂ The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.View all articles by Scott Adams
Am J Gastroenterol. 2003 Oct;98(10):2289-92
Celiac.com 11/26/2003 - The results of a study conducted by Dr. Joseph Murray and colleagues at the Mayo Clinic in Rochester, Minnesota indicate that an unusually high number of those with celiac disease do not develop immunity from the hepatitis B vaccine. The team looked at 23 clinically diagnosed celiacs who had been given a full series of hepatitis B vaccines. Out of this group they identified 19 who had been tested for hepatitis B Vaccine response, and of the 19 tested, 13 subjects did not develop long-term immunity to the vaccine, which was determined by utilizing the negative qualitative or quantitative anti-HBs antibody titer.
The researchers note a strong association in celiac disease with a particular HLA genotype of DQ2, which is also seen in nonresponders to the hepatitis B vaccine. Each of the subjects in the study was either homozygous or heterozygous for DQ2. The researchers postulate that a majority of celiacs may be non-responsive to the vaccine because they have "a failure of induction of humoral immune response needed for development of long term immunity." The researchers are still uncertain of the specific cause of the failed immune system response in those with celiac disease.
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