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Tissue Transglutaminase Autoantibody Detection in Saliva: Accurate Celiac Disease Screening Method
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I foundedÂ The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.View all articles by Scott Adams
J Pediatr. 2004 May;144(5):632-6
Celiac.com 05/10/2004 - Italian researchers compared the serum samples from 39 celiac disease patients who were diagnosed with celiac disease after their first biopsy with 32 controls who had normal duodenal mucosa and 32 healthy volunteers. Salivary transglutaminase autoantibodies were detected in 97.4% of the patients who had celiac disease, and in 100% of their corresponding serum samples. All of the 32 healthy volunteers tested negative for both serum and saliva transglutaminase autoantibodies. The researchers conclude "This study demonstrates that it is possible to detect salivary transglutaminase autoantibodies in celiac disease with a non-invasive, simple to perform, reproducible and sensitive method."
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Saliva Screening for Anti-transglutaminase Autoantibody Effective for Diagnosing Celiac Disease in Children
Driven by the high prevalence of celiac disease, a team of researchers based in Italy to assess a new, noninvasive disease screening strategy that would allow them to make an early diagnosis of celiac disease in 6- to 8-year-old children.... [READ MORE]
Tissue Transglutaminase Antibody Screening May Replace the Biopsy in the Diagnosis of Celiac Disease
Pediatrics 2005;115:1341-1346.... [READ MORE]
Commercial Tissue Transglutaminase (tTG) Lab Screenings May Miss Many Cases of Celiac Disease
A new study that was presented on November
1, 2004 by Julian Abrams, MD, and colleagues from Columbia University
Medical Center in New York City at the American College of Gastroenterology
(ACG) 69th Annual Scientific Meeting indicates that using only antibody
to tissue transglutaminase (tTG) to diagnose celiac disease will likely
result in missed diagnoses—and the accuracy of the tTG results depends
on which lab conducts the test.... [READ MORE]
Italian Researchers Develop Ultra-Sensitive Intestinal Anti-Tissue Transglutaminase Celiac Disease Screening Technique
J Autoimmun.... [READ MORE]