No popular authors found.

Categories

No categories found.


Join Celiac.com's forum / message board and get your questions answered! Our forum has nearly 1 MILLION POSTS, and over 62,000 MEMBERS just waiting to help you with any questions about celiac disease and the gluten-free diet. We'll see you there!






Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus RSS Podcast Email  Get Email Alerts

SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Rod-Shaped Bacteria May Trigger Celiac Disease

Am J Gastroenterol. 2004 May;99(5):894-904

Celiac.com 06/08/2004 – To determine what triggers celiac disease, researchers recently used an electron microscope to look at the jejunal biopsies of several groups of children: A group with untreated celiac disease, one with treated celiac disease, another with challenged celiac disease, and a healthy control group. The researchers discovered rod-shaped bacteria attached to the small intestinal epithelium in both the treated and untreated celiac-disease groups, but not in the healthy control group.

The researchers conclude: "Unique carbohydrate structures of the glycocalyx/mucous layer are likely discriminating features of celiac disease patients. These glycosylation differences could facilitate bacterial adhesion. Ectopic production of MUC2, HD-5, and lysozyme in active celiac disease is compatible with goblet and Paneth cell metaplasia induced by high interferon-gamma production by intraepithelial lymphocytes."

The idea that bacteria may be involved in the pathogenesis of celiac disease is a hypothesis that was also proposed by Roy S. Jamron in an article that originally appeared in the Spring 2004 edition of Celiac.coms Scott-Free Newsletter, which is further supported by this research.

Celiac.com welcomes your comments below (registration is NOT required).



Related Articles




Spread The Word





Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *: