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Celiac Disease Missed as Cause of Iron-Deficiency Anemia

Br J Haematol 2000;111:898-901.

Celiac.com 02/15/2001 - As reported in the December issue of the British Journal of Haematology, Dr. D. J. Unsworth of Southmead Hospital in Bristol, UK, and colleagues examined 483 blood samples that were found to be anemic (hemoglobin <11 g/dL for women, <13.5 g/dL for men). Of this group, 28 women (26 premenopausal) and 4 men tested positive for IgA anti-endomysial antibodies, and were further tested for celiac disease. 25 from this group underwent endoscopic small intestinal biopsies, and 22 of them had histological changes compatible with celiac disease. Of the group of 22, twenty-one were women, and none of them had been previously tested for the possibility of celiac disease.

Results: The researchers found that by screening anemic adults for celiac disease they ended up with a detection rate of 6%, compared with 0% detection of celiac disease using EDTA blood samples from 250 non-anemic blood donors.

Conclusion: Celiac disease in menstruating women is under-investigated as a potential cause of iron-deficiency anemia. Celiac disease serology is easy, cheap and reliable, and the researchers recommend that all cases of anemia with an uncertain cause, including when the only cause is though to be menstruation, be tested for celiac disease-associated autoantibodies.

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2 Responses:

 
Carol
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said this on
24 Jun 2010 9:43:34 AM PST
I have to take ferritin (iron) supplement because celiac disease apparently affects one's absorption of iron. Have noticed what appears to be clusters of hemosiderin deposits on feet near ankles.

 
Yvonne
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said this on
29 Jul 2013 10:17:46 PM PST
I recently found out that I now have celiac, however with all that I am learning about it, I am realizing that I may have had it my whole life, but it recently just went into over drive. I am 46 and am perimenopausal, heavy periods, and am hypoglycemic, and anemic and that my hypoglycemia never went away after having my daughter due to already having symptoms of or early stages of celiac. I now suffer with headaches, fatigue, restlessness at night, nausea and heightened hunger pains, and almost no energy, or strength!




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