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Celiac Disease & Gluten Intolerance Research

This category contains summaries of research articles that deal strictly with scientific research publications on celiac disease. Most of these research summaries contain the original source of the publication.

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    Sufferers of C. difficile infections have new hope in fecal translpants. Photo: CC--Kevin Jarrett.

    Sufferers of clostridium difficile infection have new hope in fecal transplants. Doctors understand better why they work.



    People with non-celiac gluten sensitivity seem to have distinct gut and biological conditions. Photo: CC--Dennis Jarvis

    A new study looks at intestinal cell damage and systemic immune activation in individuals reporting wheat sensitivity, but no celiac disease.



    Photo: CC--Akinori Yamada

    Does the season or region of birth influence celiac disease risk? New science says yes.



    Photo: CC--Coolabanana

    Although serological tests are useful for identifying celiac disease, it is well known that a small minority of celiacs are seronegative, and show no blood markers for celiac disease. A team of researchers wanted to define the prevalence and features of seronegative compared to seropositive celiac disease, and to establish whether celiac disease is a common cause of seronegative villous atrophy.



    Most celiac patients improve on a gluten-free diet. Photo: CC--Leonel Silva

    Many doctors hear from celiac patients who suffer from persistent symptoms despite a long-term gluten-free diet. A research team recently set out to investigate the prevalence and severity of these symptoms in patients with variable duration of a gluten-free diet.



    Innate IEL compartment loses differentiation potential in patients with RCDII. Photo: CC--Joe Dyer

    Study shows previously unappreciated diversity and plasticity of innate IEL compartment, along with loss of differentiation potential in patients with RCDII.



    Gluten triggers symptoms in some types of non-celiac gluten sensitivity. Photo: CC--Joe Dyer

    Some researchers have suggested that gluten may not be the actual trigger of symptoms in non-celiac gluten sensitivity. Others feel that gluten is definitely the trigger, especially in certain cases.



    Metagenomics shows dysbiosis and a potentially pathogenic N. flavescens strain in adult celiac tatients. Photo: CC--Jason Wilson

    Metagenomics shows dysbiosis and a potentially pathogenic N. flavescens strain in adults with celiac disease.



    Duodenal bacteria in celiac patients impacts gluten breakdown and immunogenicity differently than in healthy subjects. Photo: CC--Gorupka

    Symptoms and damage in celiac disease is caused by partially-degraded gluten peptides from wheat, barley and rye. Susceptibility genes are necessary to trigger celiac disease, but they can't do it alone. Some researchers suspect that these susceptibility genes might get help from conditions resulting from unfavorable changes in the microbiota.



    Photo: CC--Todd Chandler

    Study shows gliadin peptide p31-43 activates celiac-related innate immune pathways in vivo, also hints at a common mechanism for interaction between dietary gluten and viral infections in triggering celiac disease.



    Gluten-free diet has a positive effect on lymphoid cells in the rectal mucosa of non-celiac wheat sensitivity patients. Photo: CC--Vater Fotografo

    A gluten-free diet reverses type 1 innate lymphoid cells in the rectal mucosa of patients with non-celiac wheat sensitivity



    Do aptamers hold the key to faster gluten detection? Photo: CC--Mark Morgan

    Can aptamers help researchers design biosensors for fast and selective measurement of gluten in foods?



    German researchers seeking better wheat varieties are studying wheat sensitivity. Photo: CC-- Takuma Kimura

    With funds from the German Research Foundation, the Universities of Mainz and Hohenheim join forces to study wheat sensitivity in search for better tolerated wheat varieties.



    Vaccines can help protect celiac disease patients from pneumonia. Photo: CC--Helge V. Keitel

    Doctors generally recommend that celiac disease patients receive pneumococcal vaccination, but little has been done to quantify risk levels.



    Duodenal switch surgery leads to celiac disease in strange case. Photo: CC--Marco Bellucci

    Unique case details clinical celiac disease following duodenal switch surgery.



    Photo: CC--Tanakawho

    Do people with non-celiac wheat sensitivity have more anti-nuclear antibodies than those with celiac disease?



    Image: CC--Jeff Turner

    Do all patients with potential celiac disease need a gluten-free diet? The transformation of potential celiac disease to full-blown celiac disease has been described in some western clinical studies, but there is no good data on cases in Asia.



    Photo: CC--Miles Goodhew

    People with potential celiac disease have blood and genetic markers for celiac disease, but show little or no damage to the small intestinal mucosa. Do they always need a gluten-free diet?



    Photo: CC--Money Images

    Does the preferential xxpression of HLA-DQ2.5 Genes in celiac disease impact T cell response?



    How useful is celiac disease without biopsy? Photo: CC--Military Health

    Considering the new ESPGHAN and BSPGHAN guidelines, how useful is celiac diagnosis without biopsy?


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