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Celiac Disease & Gluten Intolerance Research

This category contains summaries of research articles that deal strictly with scientific research publications on celiac disease. Most of these research summaries contain the original source of the publication.

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    Photo: CC--shingleback

    A number of studies have shown that increased breastfeeding may provide some protection against celiac disease. Other studies show no significant difference in the prevalence of celiac disease between breastfed and non-breastfed patients. What's the deal?



    Photo: CC--teuobk

    A number of studies support the existence non-celiac gluten sensitivity, which can be marked by both internal and external symptoms in individuals with normal small-bowel mucosa and negative results on serum anti-transglutaminase and anti-endomysial antibody testing. These symptoms are very similar to traditional celiac disease symptoms, and seem to improve or disappear with the adoption of a gluten-free diet.



    Photo: CC--Daniel Paquet

    Last year, ImmusanT's Nexvax2 celiac disease vaccine passed its phase 1 clinical trials in Australia and New Zealand, causing a stir of hope and anticipation within the celiac disease community. It will still be a while before the vaccine is available to the public, but yesterday ImmusanT announced that it commenced phase 1b clinical trials in New Zealand and Australia and phase 1 clinical trials in the U.S.



    Celiac disease numbers in Western countries are currently somewhere in the 1:100 range, but this does not account for a host of non-celiac gluten intolerant people. For many, it is common knowledge that gluten and wheat intolerance manifests in a variety of forms, and not all of them are diagnosable as celiac disease. This has not prevented the existence of such non-celiac wheat sensitivities from being debated in scientific circles though. A double-blind placebo-controlled study spanning 2001-2011 demonstrates that wheat sensitivity exists as a distinct clinical condition, separate from celiac disease.



    Photo: CC--Håkan Dahlström.

    A team of researchers recently set out to determine whether testing IgG and IgA antibodies Against native gliadin was best for diagnosing celiac disease in children under 2-years old. Specifically they wanted to compare the performance of assays for anti-nGli, anti-dGli, anti-tTG, and EmA in this age group.



    Photo: CC--SidPix2

    One of the least talked about symptoms of celiac disease in children is a delaying of sexual maturation. Previous studies have established this effect, but they have not clearly explored whether treatment of celiac disease (via gluten-free diet) can restore sexual maturation to a normal rate.



    Photo: CC--a.drian

    Failure to conduct small bowel biopsies during endoscopy, especially on men and people of color, may be one of the reasons that celiac disease remains under-diagnosed in the United States, according to a new study.



    Between 1984 and 1996, Sweden experienced a celiac disease epidemic: celiac disease rates shot up to four times normal levels, then dropped just as abruptly ten years later. This is interesting because it shows that there is some environmental cause for the disease, but the nature of that cause is proving hard to pinpoint.



    Photo: CC--Gonzo Charles

    A research team recently set out to study how bone mineral density correlates with duodenal Marsh stage in newly diagnosed adult celiac patients. The team made up of A. García-Manzanares, J.M. Tenias, and A.J. Lucendo.



    Photo: CC--Valerie_Everett

    A group of researchers recently set out to study cases of positive tissue transglutaminase antibodies with negative endomysial antibodies to determine whether or not such cases amount to celiac disease.



    Photo: CC - Cuito Cuanavale

    There have been several studies of celiac disease sufferers and health-related quality of life (HRQoL), but few of these studies have focused on children. Since diseases that develop through childhood (as celiac disease often does) usually negatively impact physical, social and psychological development, it is important to determine the extent to which celiac children suffer as a result of the disease.



    Photo: CC -- Emeraldimp

    In general, doctors and researchers know a good deal about how celiac disease works, and they are finding out more all the time. However, they know very little about non-celiac gluten sensitivity (NCGS).



    Photo: CC--Certified Su

    In a new study, researchers at Brigham and Women's Hospital (BWH) addressed whether the genetic risk of the most common medical conditions, including celiac disease, stems from many rare mutations that each confer a high degree of risk in various people, or from common differences throughout the genome that modestly influence risk.



    Photo: CC--Nathan Reading

    From what we understand about celiac disease, both genetic and environmental factors play a part in its development: people with certain genetic dispositions are more likely to develop it, but studies of high-risk twins have shown that in 25% of cases, only one of the twins will develop the disease.



    Photo: CC - Argonne National Laboratory

    Two researchers recently conducted an assessment of the contribution of celiac disease autoantibodies to the disease process.



    Photo: CC--adrigu

    We know from past studies that the intestinal bacteria communities of children with celiac disease differ greatly from those of healthy children, but there has been little work done to draw such a correlation with adult celiac disease sufferers.



    Goblet Cells

    Goblet cells that line the intestine and secrete mucous are emerging as a possible target for treating inflammatory bowel disease, celiac disease and food allergies.



    Photo: CC--Joe Mabel

    Should gluten sensitivity be thought of as “celiac light,” as just one of the milder manifestations within the wider spectrum of celiac disease? Some doctors and researchers think so.



    Photo: CC-Moyan Brenn

    Horses are susceptible to inflammatory small bowel disease, and the condition effects horses in much the same way as it effects humans. A research team recently conducted a study to examine the possibility that gluten may play a role in equine ISBD.



    Photo: CC--pedrosimoes7

    Doctors and researchers are still debating the usefulness of active blood screening for spotting celiac disease in older populations. Studies do suggest that many cases of celiac disease go undetected, especially in the older population. One unanswered question is whether screening does any good for older people who have been eating gluten many decades.


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