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Celiac Disease & Gluten Intolerance Research

This category contains summaries of research articles that deal strictly with scientific research publications on celiac disease. Most of these research summaries contain the original source of the publication.

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    Photo: CC--Nathan Reading

    From what we understand about celiac disease, both genetic and environmental factors play a part in its development: people with certain genetic dispositions are more likely to develop it, but studies of high-risk twins have shown that in 25% of cases, only one of the twins will develop the disease.



    Photo: CC - Argonne National Laboratory

    Two researchers recently conducted an assessment of the contribution of celiac disease autoantibodies to the disease process.



    Photo: CC--adrigu

    We know from past studies that the intestinal bacteria communities of children with celiac disease differ greatly from those of healthy children, but there has been little work done to draw such a correlation with adult celiac disease sufferers.



    Goblet Cells

    Goblet cells that line the intestine and secrete mucous are emerging as a possible target for treating inflammatory bowel disease, celiac disease and food allergies.



    Photo: CC--Joe Mabel

    Should gluten sensitivity be thought of as “celiac light,” as just one of the milder manifestations within the wider spectrum of celiac disease? Some doctors and researchers think so.



    Photo: CC-Moyan Brenn

    Horses are susceptible to inflammatory small bowel disease, and the condition effects horses in much the same way as it effects humans. A research team recently conducted a study to examine the possibility that gluten may play a role in equine ISBD.



    Photo: CC--pedrosimoes7

    Doctors and researchers are still debating the usefulness of active blood screening for spotting celiac disease in older populations. Studies do suggest that many cases of celiac disease go undetected, especially in the older population. One unanswered question is whether screening does any good for older people who have been eating gluten many decades.



    Image: Sourdough starter: CC--andersbknudsen
    A team of researchers has found that gluten-free sourdough products may help speed recovery at start of gluten-free diet.


    Photo: CC - Jeremy Bronson
    Biopharmaceutical development company, BioLineRx, has announced results from pre-clinical trials which show that their compound, BL-7010, an orally available treatment for celiac disease, reduces the toxic effects of gluten in patients with celiac disease.


    Photo: CC - jimmedia
    After numerous studies over several decades showing higher mortality rates in people with celiac disease, including a comprehensive study in 2009, published in Gastroenterology, news of a recent UK study, finding mortality rates for people with untreated celiac disease that are similar to the general population, has raised a few eyebrows.


    Photo: CC - articotropical
    A clinical research team wanted to determine if adding ascorbate (vitamin C) to gliadin-stimulated biopsy culture could reduce the mucosal immune response to gliadin in people with celiac disease.


    Photo: CC - sanofi pasteur
    People with thyroiditis and untreated celiac disease may suffer from reduced thyroid-stimulating hormone levels, a new study has found. Those people may require supplemental doses of thyroxine to normalize their thyroid-stimulating hormone levels.


    Photo: CC - rdecom
    A group of researchers recently studied the ways in which HLA-DQ2 and DQ8 might influence the severity of celiac disease. Specifically, the team wanted to study HLA-DQA1 and DQB1 profiles in adults with different forms of celiac disease, including adults with complicated and potential celiac disease, the most seriously affected, and those with the best preserved histologic data on the pathologic celiac spectrum.


    Photo: CC--tiny.cc
    Even though nearly all drug-development programs include gluten challenges, very little is known about the duration of gluten challenge and gluten dosage. That is, how quickly does gluten cause damage, and at what dosages?


    Photo: Leeds Museums Galleries, UK.

    Currently, the best way to assess whether patients with celiac disease are actually maintaining a strict gluten-free diet is to have trained experts conduct a dietary interview. These interviews can vary in complexity, depending on the nature and number of the questions, and on the amount of medical expertise required to score the responses.



    Photo: CC-hagit
    Currently, testing for anti tissue-transglutaminase antibodies is the standard of celiac disease blood testing. The test has a high sensitivity in patients who are eating a diet that contains gluten, but poor sensitivity for people on a gluten-free diet. So, it's not much use for measuring gluten-free diet success in people with celiac disease.


    Photo: CC-Bogdan Suditu
    A research team recently conducted a dense genotyping non-HLA risk loci previously associated with immune-mediated diseases in individuals with celiac disease.


    Some studies suggest that people with celiac disease may have high levels of resistance to the HBV vaccine, compared to the general population. A team of researchers recently took a look at the issue of HBV vaccine reliability in people with celiac disease.


    Photo: Gene Davis -- Smithsonian Institution
    Should there be mass screening for celiac disease? Currently, there is no consensus among scientists or among public policy makers in favor of mass screening for celiac disease as a public health intervention. Advocacy for mass celiac disease screening remains somewhat controversial.


    Photo: CC--Glenn Fleishmann
    A research team recently set out to examine connections between childhood celiac disease and functional gastrointestinal disorder in children meeting Rome III criteria.

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