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Celiac Disease & Gluten Intolerance Research

This category contains summaries of research articles that deal strictly with scientific research publications on celiac disease. Most of these research summaries contain the original source of the publication.

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    How long does it take for serology to normalize in celiac children on a gluten-free diet? Photo: CC--Hannenah710

    If kids with celiac disease go on a gluten-free diet, how quickly does their serology return to normal?



    Photo: US Army Materiel Command

    New research shows that most patients with SNVA, especially non-white patients, do not have celiac disease.



    Photo: CC--Aini

    Transglutaminase 2-specific celiac disease autoantibodies cause morphological changes and inflammation in the small-bowel mucosa of mice.



    Image: CC--nicole danielson

    Could the amount of gluten matter more than breast-feeding or the timing of the introduction of gluten as a trigger for celiac disease?



    Researchers discover aberrant epigenetic regulation behind the intestinal symptoms in celiac disease. Photo: CC--EveryCarListed P

    Celiac disease is an autoimmune disease in genetically susceptible individuals and is triggered by adverse immune reactions to gluten, a protein found in wheat and other grains.



    Image: CC--Swallowtail Garden Seeds
    Researchers say carnivorous plant enzymes could help celiacs digest gluten, could work like Beano.


    Older people can show atypical signs of celiac disease. Photo: CC--Paul L. Dineen

    Older people often show clinically atypical symptoms of celiac disease, which can delay diagnosis.



    Sufferers of C. difficile infections have new hope in fecal translpants. Photo: CC--Kevin Jarrett.

    Sufferers of clostridium difficile infection have new hope in fecal transplants. Doctors understand better why they work.



    People with non-celiac gluten sensitivity seem to have distinct gut and biological conditions. Photo: CC--Dennis Jarvis

    A new study looks at intestinal cell damage and systemic immune activation in individuals reporting wheat sensitivity, but no celiac disease.



    Photo: CC--Akinori Yamada

    Does the season or region of birth influence celiac disease risk? New science says yes.



    Photo: CC--Coolabanana

    Although serological tests are useful for identifying celiac disease, it is well known that a small minority of celiacs are seronegative, and show no blood markers for celiac disease. A team of researchers wanted to define the prevalence and features of seronegative compared to seropositive celiac disease, and to establish whether celiac disease is a common cause of seronegative villous atrophy.



    Most celiac patients improve on a gluten-free diet. Photo: CC--Leonel Silva

    Many doctors hear from celiac patients who suffer from persistent symptoms despite a long-term gluten-free diet. A research team recently set out to investigate the prevalence and severity of these symptoms in patients with variable duration of a gluten-free diet.



    Innate IEL compartment loses differentiation potential in patients with RCDII. Photo: CC--Joe Dyer

    Study shows previously unappreciated diversity and plasticity of innate IEL compartment, along with loss of differentiation potential in patients with RCDII.



    Gluten triggers symptoms in some types of non-celiac gluten sensitivity. Photo: CC--Joe Dyer

    Some researchers have suggested that gluten may not be the actual trigger of symptoms in non-celiac gluten sensitivity. Others feel that gluten is definitely the trigger, especially in certain cases.



    Metagenomics shows dysbiosis and a potentially pathogenic N. flavescens strain in adult celiac tatients. Photo: CC--Jason Wilson

    Metagenomics shows dysbiosis and a potentially pathogenic N. flavescens strain in adults with celiac disease.



    Duodenal bacteria in celiac patients impacts gluten breakdown and immunogenicity differently than in healthy subjects. Photo: CC--Gorupka

    Symptoms and damage in celiac disease is caused by partially-degraded gluten peptides from wheat, barley and rye. Susceptibility genes are necessary to trigger celiac disease, but they can't do it alone. Some researchers suspect that these susceptibility genes might get help from conditions resulting from unfavorable changes in the microbiota.



    Photo: CC--Todd Chandler

    Study shows gliadin peptide p31-43 activates celiac-related innate immune pathways in vivo, also hints at a common mechanism for interaction between dietary gluten and viral infections in triggering celiac disease.



    Gluten-free diet has a positive effect on lymphoid cells in the rectal mucosa of non-celiac wheat sensitivity patients. Photo: CC--Vater Fotografo

    A gluten-free diet reverses type 1 innate lymphoid cells in the rectal mucosa of patients with non-celiac wheat sensitivity



    Do aptamers hold the key to faster gluten detection? Photo: CC--Mark Morgan

    Can aptamers help researchers design biosensors for fast and selective measurement of gluten in foods?



    German researchers seeking better wheat varieties are studying wheat sensitivity. Photo: CC-- Takuma Kimura

    With funds from the German Research Foundation, the Universities of Mainz and Hohenheim join forces to study wheat sensitivity in search for better tolerated wheat varieties.


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