- Celiac Disease & Gluten Intolerance Research
Celiac Disease & Gluten Intolerance Research
Between 1984 and 1996, Sweden experienced a celiac disease epidemic: celiac disease rates shot up to four times normal levels, then dropped just as abruptly ten years later. This is interesting because it shows that there is some environmental cause for the disease, but the nature of that cause is proving hard to pinpoint.
A research team recently set out to study how bone mineral density correlates with duodenal Marsh stage in newly diagnosed adult celiac patients. The team made up of A. García-Manzanares, J.M. Tenias, and A.J. Lucendo.
A group of researchers recently set out to study cases of positive tissue transglutaminase antibodies with negative endomysial antibodies to determine whether or not such cases amount to celiac disease.
There have been several studies of celiac disease sufferers and health-related quality of life (HRQoL), but few of these studies have focused on children. Since diseases that develop through childhood (as celiac disease often does) usually negatively impact physical, social and psychological development, it is important to determine the extent to which celiac children suffer as a result of the disease.
In general, doctors and researchers know a good deal about how celiac disease works, and they are finding out more all the time. However, they know very little about non-celiac gluten sensitivity (NCGS).
In a new study, researchers at Brigham and Women's Hospital (BWH) addressed whether the genetic risk of the most common medical conditions, including celiac disease, stems from many rare mutations that each confer a high degree of risk in various people, or from common differences throughout the genome that modestly influence risk.
From what we understand about celiac disease, both genetic and environmental factors play a part in its development: people with certain genetic dispositions are more likely to develop it, but studies of high-risk twins have shown that in 25% of cases, only one of the twins will develop the disease.
Two researchers recently conducted an assessment of the contribution of celiac disease autoantibodies to the disease process.
We know from past studies that the intestinal bacteria communities of children with celiac disease differ greatly from those of healthy children, but there has been little work done to draw such a correlation with adult celiac disease sufferers.
Goblet cells that line the intestine and secrete mucous are emerging as a possible target for treating inflammatory bowel disease, celiac disease and food allergies.
Should gluten sensitivity be thought of as “celiac light,” as just one of the milder manifestations within the wider spectrum of celiac disease? Some doctors and researchers think so.
Horses are susceptible to inflammatory small bowel disease, and the condition effects horses in much the same way as it effects humans. A research team recently conducted a study to examine the possibility that gluten may play a role in equine ISBD.
Doctors and researchers are still debating the usefulness of active blood screening for spotting celiac disease in older populations. Studies do suggest that many cases of celiac disease go undetected, especially in the older population. One unanswered question is whether screening does any good for older people who have been eating gluten many decades.