Celiac Disease & Gluten Intolerance Research

A British study reports that 40% of celiacs are unhappy on the gluten free diet and would welcome treatment options, but do not use alternative therapies more than the control population.

Gluten Intolerance as a separate entity from celiac disease has been viewed with skepticism by the scientific community, since there was no discernible explanation for it. Yet most researchers and clinicians now admit that it seems to be real.

Serological screening of asymptomatic people at risk for celiac disease is an effective method for spotting the disease and prompting early treatment, according to the results of a study by researchers from Finland.

Photo: CC-jayneandd

Children born in the spring or summer seem to have higher rates of celiac disease, according to a study of Massachusetts children. This higher rate could be tied to certain seasonal and environmental factors, according to researchers at the Massachusetts General Hospital for Children.

Romanian researchers suggest that the absence of HLA DQ2 and DQ8 haplotypes should not be used to rule out a diagnosis of celiac disease.

New genetic research on celiac disease opens the door to much hope for people with this autoimmune disorder.

A research team recently set out to examine multiple independent variants in 6q21-22 associated with susceptibility to celiac disease in the Dutch, Finnish and Hungarian populations.

New research indicates DHA could help treat celiacs.

Enterocytes in celiac patients produce the proinflammatory molecule arachidonic acid upon exposure to gluten; DHA, a long chain fatty acid, can suppress this effect.

N new study on gluten sensitivity and celiac disease. Photo: CC-Ell Brown

A new study supports the existence of gluten sensitivity and celiac disease as two clinically different gluten-associated disorders.

New study on blocking Interleukin-15 to treat celiac disease symptoms

By blocking an inflammatory protein called interleukin-15 (IL-15), doctors may be able to treat and prevent symptoms of celiac disease in some people, according to a new study in the journal Nature.

New research could lead to treatment for celiac disease.

A January study by Czech researchers found at least one thing that affects the permeability of the intestinal mucosa: gut bacteria. Their study may eventually lead to treatment options for human celiacs, by finding ways to protect tender intestines from the harmful effects of gliadin.

New research on gliadin peptide and celiac disease. Photo: Microscope - CC - Sarah_G

A team of researchers recently identified a novel immunomodulatory gliadin peptide that triggers interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with celiac disease.

New study in AJG indicates new genetic factors influence CD.

Although the HLA-DQ locus is clearly the strongest genetic factor influencing the development of celiac disease, it is certainly possible that other genes play supporting roles. Identifying these genes could help shed light on why certain genetically susceptible individuals develop celiac while others can happily (and healthily) eat gluten.

Study on quality of life in celiacs with IBD and acid reflux.

A cross sectional study in the UK reports that celiac and IBD patients have more severe reflux and irritable bowel syndrome, and therefore lower Quality of Life, than healthy controls.

New AJG study on celiac diagnosis and death rates.

New blood screening tests have improved rates of diagnosis for celiac disease in recent decades, but better diagnosis has not reduced celiac-associated deaths, according to a report by UK researchers in the American Journal of Gastroenterology.

New research on mucosal recovery and CD.

A group of clinicians recently set out to assess rates of mucosal recovery under a gluten-free diet in adults with celiac disease, and to gauge the clinical prospects of ongoing mucosal damage in celiac patients who follow a gluten-free diet.

New study on gluten intolerance without celiac disease appears in the latest AJG.

In what may seem for some like an obvious finding, a team of Australian researchers has shown that people can suffer gluten intolerance without having celiac disease. Their study is published in The American Journal of Gastroenterology.

New study indicates more people should be gluten-free.

In a new study, researchers found that people with celiac disease symptoms have the same distinctive metabolic fingerprint as patients with full-blown disease, and who must follow a gluten-free diet to avoid permanent damage to the gut.

New study finds no link between early psychological stress and CD.

A small study in Swedish children has found no association between early childhood psychological stress and later development of celiac disease. Previous studies have shown links between psychological stress and a number immunological diseases, such as inflammatory bowel disease.

Scientists suspect environmental factors fueling higher celiac disease rates, older patients.

A recent study shows that, since 1974, the rate of celiac disease has doubled every fifteen years, and that celiac rates increase as people grow older, with many developing the disease in their 50s or 60s.