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<channel><title><![CDATA[Celiac Disease & Gluten-free Diet Information Since 1995 at Celiac.com - Comments for article: Celiac Disease Genetics]]></title><link>http://www.celiac.com</link><description /><language>en-us</language><copyright><![CDATA[http://www.celiac.com]]></copyright><generator>N/A</generator><webMaster>scott@celiac.com</webMaster><lastBuildDate>Sat, 21 Nov 2009 04:41:57 PST</lastBuildDate><ttl>20</ttl><item><title><![CDATA[Comment #1]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2756</link><description><![CDATA[Excellent information.  But we are still assuming that certain genes like to travel together and therefore certain white cell antigens travel with the genetic determinants of celiac disease.  Will there eventually be a specific chromosome test for celiac?<br/><br/>
(Comment posted by Frances Collier, MT, VMD at 9:45 am, Tue 26th Aug 2008)]]></description><author>no@spam.com (Frances Collier, MT, VMD)</author><pubDate><![CDATA[Tue, 26 Aug 2008 09:45:47 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2756</guid></item><item><title><![CDATA[Comment #2]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2759</link><description><![CDATA[Great information!<br/><br/>
(Comment posted by Katherine Robertson at 1:29 pm, Tue 26th Aug 2008)]]></description><author>no@spam.com (Katherine Robertson)</author><pubDate><![CDATA[Tue, 26 Aug 2008 13:29:57 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2759</guid></item><item><title><![CDATA[Comment #3]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2768</link><description><![CDATA[Great article<br/><br/>
(Comment posted by Sandy M at 8:46 am, Sat 30th Aug 2008)]]></description><author>no@spam.com (Sandy M)</author><pubDate><![CDATA[Sat, 30 Aug 2008 08:46:05 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2768</guid></item><item><title><![CDATA[Comment #4]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2771</link><description><![CDATA[I understood the explanation!  I will send this to my [grown] son to present to his family physician who seems to resist allowing my son to be tested.<br/><br/>
(Comment posted by Diane Dreiling at 3:36 pm, Sun 31st Aug 2008)]]></description><author>no@spam.com (Diane Dreiling)</author><pubDate><![CDATA[Sun, 31 Aug 2008 15:36:26 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2771</guid></item><item><title><![CDATA[Comment #5]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2782</link><description><![CDATA[One of the most informative and understandable articles I've read in a very long time.  Thank you!<br/><br/>
(Comment posted by Susie at 6:39 pm, Mon 1st Sep 2008)]]></description><author>no@spam.com (Susie)</author><pubDate><![CDATA[Mon, 01 Sep 2008 18:39:01 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2782</guid></item><item><title><![CDATA[Comment #6]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2784</link><description><![CDATA[Very explanatory article. Thank you!<br/><br/>
(Comment posted by Blondy at 11:24 am, Tue 2nd Sep 2008)]]></description><author>no@spam.com (Blondy)</author><pubDate><![CDATA[Tue, 02 Sep 2008 11:24:29 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2784</guid></item><item><title><![CDATA[Comment #7]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2788</link><description><![CDATA[This is the best explanation that I have seen thus far that is in understandable layman's terms.  I'll pass it on to my daughter who often wonders if she, too, will become a celiac<br/><br/>
(Comment posted by Janet at 6:57 pm, Tue 2nd Sep 2008)]]></description><author>no@spam.com (Janet)</author><pubDate><![CDATA[Tue, 02 Sep 2008 18:57:06 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2788</guid></item><item><title><![CDATA[Comment #8]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2791</link><description><![CDATA[Thank you for this article!  I was just attempting to figure this out by discussing this with a fellow boardie this past month. While your 'Ten Facts' article was great, this article makes things as crystal clear as it can for the lay-person, and now I have better understanding for what our fellow boardie was sharing and then some!<br/><br/>
(Comment posted by debslo at 3:33 pm, Wed 3rd Sep 2008)]]></description><author>no@spam.com (debslo)</author><pubDate><![CDATA[Wed, 03 Sep 2008 15:33:38 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2791</guid></item><item><title><![CDATA[Comment #9]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2859</link><description><![CDATA[Genetic testing should be a part of every family's medical regimen.  Speak to your congressional representative.  The later a person is diagnosed with celiac disease or any other inherited disorder the more damages a person must attempt to overcome.  Seems to me an obvious course of action.<br/><br/>
(Comment posted by Beatrice at 8:30 am, Thu 18th Sep 2008)]]></description><author>no@spam.com (Beatrice)</author><pubDate><![CDATA[Thu, 18 Sep 2008 08:30:52 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment2859</guid></item><item><title><![CDATA[Comment #10]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3044</link><description><![CDATA[Excellent Article... it has been very helpful and we appreciate your clear communication. Our family bears out the research on genetic testing and specific alpha and beta sub-unit findings you mention here.<br/><br/>
(Comment posted by Tammy at 7:09 pm, Sat 1st Nov 2008)]]></description><author>no@spam.com (Tammy)</author><pubDate><![CDATA[Sat, 01 Nov 2008 19:09:52 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3044</guid></item><item><title><![CDATA[Comment #11]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3422</link><description><![CDATA[I have been a 'working' geneticist dealing with a variety of species for the past 30 years. My wife and her family have been identified as having celiac disease -- hers being one of the horror stories of being caught in the 'system'.
However, I find the emphasis on HLA typing to be misguided.  HLA types 'may' be associate with risk factors -- but, these are fundamentally no more than simple correlation analyses and say nothing of causation.  therefore, I would truly recommend against calling them 'celiac genes'. More than likely, the HLA subtypes determine the immune response of the individual when exposed to the gluten/gliadin (or possibly other) amino acid sequences. The true 'gene' for celiac -- if there is such a thing -- is more than likely an enzyme that prevents complete digestion of the glutamine-rich portion of the gluten molecule. Of course, this means that one should understand celiac disease as a 2-stage disease. The first being exposure to the antigen and the second being responses to that antigen. I strongly suspect that the DQx series of HLA subtypes are involved with the latter and NOT the former.<br/><br/>
(Comment posted by G. F. Barbato at 6:53 am, Tue 3rd Feb 2009)]]></description><author>no@spam.com (G. F. Barbato)</author><pubDate><![CDATA[Tue, 03 Feb 2009 06:53:41 PST]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3422</guid></item><item><title><![CDATA[Comment #12]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3423</link><description><![CDATA[One more thing. IMHO, genetic testing should NOT be part of 'every family's medical regimen'. Most people and a majority of doctors don't know a thing about simple mendelian inheritance -- not to mention complex multifactorial diseases. To arbitrarily test for something with no knowledge of meaning or context is just plain irresponsible. I recognize that there are a lot of people in pain and misery -- desperate for a solution, heck, even a piece of the question. But, snake-oil don't cut it.<br/><br/>
(Comment posted by G. F. Barbato at 8:47 am, Tue 3rd Feb 2009)]]></description><author>no@spam.com (G. F. Barbato)</author><pubDate><![CDATA[Tue, 03 Feb 2009 08:47:59 PST]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3423</guid></item><item><title><![CDATA[Comment #13]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3681</link><description><![CDATA[It is not possible to get this genetic testing in my large city in Canada. My daughter had been suffering with diarrhea, nausea, bloating, pain, pale for several years. Also as a student relying on pasta, pizza etc.
I have an autoimmune disease (Sjogrens) & a bad rash so I went to Scripps in La Jolla,Ca. They didn't help my rash but blood tests came back HLADQ2, & they said get more tests but they won't do them here. We sent daughter to our Dr. & a blood test suggested Coeliac but she would need to wait 6mths for biopsy & eat gluten! We paid to fly her to another province where she found out the same day for $500, plus hotel & airfare. Villi were flat,she has a picture. So much for our medicare system! Be careful what you wish for.<br/><br/>
(Comment posted by Marie at 2:01 pm, Tue 21st Apr 2009)]]></description><author>no@spam.com (Marie)</author><pubDate><![CDATA[Tue, 21 Apr 2009 14:01:34 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3681</guid></item><item><title><![CDATA[Comment #14 (Reply to Comment #13)]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment4783</link><description><![CDATA[Marie,
Trust me, our medicare is so much better! We live in Montreal but since my daughter had her US university insurance, I allowed her to have her biopsy there (also, it went faster there than here). Our portion of the cost of the biopsy was $10,000! The US system sucks. Also, my son with his Harvard health insurance had to pay $14,400 for room and board (!) for one night stay at a hospital. Only medical procedures were covered not room and board. Your $500 plus hotel was nothing compared the madness that is the US. I'm so grateful to live in Canada.<br/><br/>
(Comment posted by Kirsti at 9:24 pm, Tue 27th Oct 2009)]]></description><author>no@spam.com (Kirsti)</author><pubDate><![CDATA[Tue, 27 Oct 2009 21:24:22 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment4783</guid></item><item><title><![CDATA[Comment #15]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3691</link><description><![CDATA[G. F. Barbado wrote: 'The true 'gene' for celiac -- if there is such a thing -- is more than likely an enzyme...' 

Sorry, but this is false. Genes are DNA, not protein. They CREATE proteins. The HLA proteins are each created by a certain gene. Certain of these HLA proteins have been shown to be associated with an increased risk of celiac disease, so it may be safe to say that the corresponding genes which created them are associated with this increased risk. That it is why it is easiest to say 'The HLA DQ8 gene,' rather than saying 'the gene that codes for the HLA DQ8 protein.' 

Now certain proteins also have an enzymatic function. Enzymes are proteins which serve as catalysts (speed up) certain biochemical reactions. It's quite possible that these HLA proteins  either do mediate biochemical reactions in some altered fashion, or have defective ability to catalyze certain reactions?!

This was an excellent article!<br/><br/>
(Comment posted by Halllie at 12:49 pm, Wed 29th Apr 2009)]]></description><author>no@spam.com (Halllie)</author><pubDate><![CDATA[Wed, 29 Apr 2009 12:49:31 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3691</guid></item><item><title><![CDATA[Comment #16]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3817</link><description><![CDATA[I wish I had your article in hand when I reviewed the test I had a few years ago.   The doctor (and this was at the Columbia University Celiac Center) said that she couldn't confirm celiac from the genetic result (and I was already symptomatic!).<br/><br/>
(Comment posted by david turkheimer at 6:58 am, Wed 20th May 2009)]]></description><author>no@spam.com (david turkheimer)</author><pubDate><![CDATA[Wed, 20 May 2009 06:58:26 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3817</guid></item><item><title><![CDATA[Comment #17]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3842</link><description><![CDATA[This is an excellent article! So well written--understandable and with thorough explanations. Thank you!!<br/><br/>
(Comment posted by Crayons574 at 12:24 pm, Sun 31st May 2009)]]></description><author>no@spam.com (Crayons574)</author><pubDate><![CDATA[Sun, 31 May 2009 12:24:55 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment3842</guid></item><item><title><![CDATA[Comment #18]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment4094</link><description><![CDATA[What a great, simple to read, informative article. Many thanks for the clear explanation. As someone with HLA2,2 and symptoms, this article helps me understand celiac disease and GSE even if my gastroenterologist doesn't.<br/><br/>
(Comment posted by Joan White at 6:13 pm, Mon 20th Jul 2009)]]></description><author>no@spam.com (Joan White)</author><pubDate><![CDATA[Mon, 20 Jul 2009 18:13:23 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment4094</guid></item><item><title><![CDATA[Comment #19]]></title><link>http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment4726</link><description><![CDATA[Halllie, your response, "Now certain proteins also have an enzymatic function. Enzymes are proteins which serve as catalysts (speed up) certain biochemical reactions. It's quite possible that these HLA proteins either do mediate biochemical reactions in some altered fashion, or have defective ability to catalyze certain reactions?!" strikes a nerve with me. I have had RA for most of my life (JRA to be precise) and my gluten issues started around the same time I started Enbrel, an RA med, which is an injectible protein. I have no scientific knowledge to back up my hunch but I often wondered if the Enbrel, which does an amazing job on my RA, was the catalyst that caused the gluten issues to surface. I'm awaiting test results to see if I have celiac. I'm pretty sure I do since my symptoms go away with a gluten-free diet. I'll be sure to re-read this article once I get my results so I can understand what's going on. BTW, my rheumatologist knew nothing about celiac. From everything I've been reading it seems as if any doc who has patients with a auto immune disease need to be reeducated about celiac. I'm in a high risk group and I wish that when I started complaining about these GI issues 6 years ago a doc would have put 2 and 2 together. Alas, like so many of you, I've been left to figure this out on my own. I live in a big city and go to an award winning hospital for care so there's no excuse. I guess you can say I'm in the anger phase of the gluten free journey.<br/><br/>
(Comment posted by Kris at 10:43 am, Tue 20th Oct 2009)]]></description><author>no@spam.com (Kris)</author><pubDate><![CDATA[Tue, 20 Oct 2009 10:43:26 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/21628/1/Celiac-Disease-Genetics/Page1.html#Comment4726</guid></item></channel></rss>