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<channel><title><![CDATA[Celiac Disease & Gluten-free Diet Information at Celiac.com - Comments for article: Celiac Disease in Northern India More Common Than Previously Believed]]></title><link>http://www.celiac.com</link><description /><language>en-us</language><copyright><![CDATA[http://www.celiac.com]]></copyright><generator>N/A</generator><webMaster>scott@celiac.com</webMaster><lastBuildDate>Thu, 23 May 2013 08:32:47 PDT</lastBuildDate><ttl>20</ttl><item><title><![CDATA[Comment #1]]></title><link>http://www.celiac.com/articles/22481/1/Celiac-Disease-in-Northern-India-More-Common-Than-Previously-Believed/Page1.html#Comment8405</link><description><![CDATA[There is an error in this article:  "All test subjects with positive blood screens and 10% of screen negative individuals were called for anti-tissue transglutaminase antibody blood tests."

The word "blood" is in error.  All test subjects who reported chronic or recurrent diarrhea and/or anemia, as well as children with short stature and/or failure to thrive or gain weight were THEN called back for the blood test, which was for the anti-tissue transglutaminase antibody.

Perhaps the most important conclusion of the study was left out of this article as well:

"The diagnostic criteria for celiac disease requires small-intestinal mucosal villous atrophy with crypt hyperplasia (Marsh III). However, mucosal damage develops gradually and patients may develop clinical symptoms even before classical histological changes have appeared. Two recent studies by Kurppa et al., all have elegantly demonstrated that even those with a positive serology and no villous atrophy do respond to a gluten free diet. In a subset of patients having Marsh I–II histology and positive serology, Kurppa et al. in a randomized controlled trial demonstrated alleviation of symptoms, decrease in antibody titers and improvement in histology in those who were randomized to receive gluten-free diet while there was deterioration in the small intestinal lesions in those who were continued on a gluten diet. In another study, the same author showed similar observations in  anti-	endomysial antibody positive children with either completely normal histology (Marsh 0) or at most Marsh I lesions. These two studies are quite intriguing and may lead to a change in the diagnostic criteria of celiac disease."

The paper, "Prevalence of Celiac Disease in the Northern Part of India:  A Community-Based Study," was presented in the Asia Pacific Digestive Week 2010 in Kuala Lumpur, Malasia.  The abstract was published in the Journal of Gastroenterology and Hepatology (J Gastroenterol Hepatol 2010; 25 (Suppl 2): A12).<br/><br/>
(Comment posted by Researcher at 6:16 am, Mon 28th Mar 2011)]]></description><author>no@spam.com (Researcher)</author><pubDate><![CDATA[Mon, 28 Mar 2011 06:16:30 PDT]]></pubDate><guid isPermaLink="true">http://www.celiac.com/articles/22481/1/Celiac-Disease-in-Northern-India-More-Common-Than-Previously-Believed/Page1.html#Comment8405</guid></item></channel></rss>