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Positive Ttg, Negative Biopsy

Entry posted by Skylark · - 2,183 views

This is a pretty good article that explains the December 2010 research on people with positive blood tTG or EMA blood tests and negative or Marsh 1 biopsy and its implications. Basically, because people with positive bloodwork and negative biopsy have the same metabolic markers as celiacs with full villous atrophy. The researchers recommend a gluten-free diet if you're positive on tTG or EMA, even if your biopsy is completely normal.
http://www.medpagetoday.com/Gastroenterology/GeneralGastroenterology/23955

Here is the Pubmed link to the original abstract.
http://www.ncbi.nlm.nih.gov/pubmed/21090607

In the paper it explains the potential celiacs as: "Patients with potential celiac disease were all positive for anti-tissue transglutaminase antibodies (tTGA); all but one were also EmA positive; histological examination revealed an apparently normal mucosa (Marsh 0) in 9 subjects, just an increase in intraepithelial lymphocytes (Marsh 1) in 12 and increased intraepithelial lymphocytes coupled with crypt hyperplasia (Marsh 2) in 8 patients."

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