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How Gluten Intolerance Might Work

Entry posted by Skylark · - 553 views

[quote name='landslide' timestamp='1308945213' post='711619']
I see, very interesting! The innate immunity you're referring to, I suppose it's the same as Dr Fasano mentions in the link below? "Their immune reactions were different, too [compared to Celiacs]. In the gluten-sensitive group, the response came from innate immunity, a primitive system with which the body sets up barriers to repel invaders."
Yes, that's the study. The role of an innate IL-15 response as the first step in celiac is also pretty well documented. The model is gluten -> IL-15 through innate immunity -> interferon-gamma and NK cells -> inflammation and apoptosis of epithelial cells -> abnormal antigen presentation of gliadin by DQ2 or DQ8 -> anti-gliadin antibodies -> recruitment of CD8+ cells to the intestine to "kill" the gluten -> (insert uncertain mystery step) -> TTG antibodies -> celiac.

Thing is, it's looking more and more like just the IL-15 is enough to cause some folks a heap of trouble. Some research suggests that the loss of intestinal integrity is more a result of the innate immunity than autoimmunity.

Scratched teflon is bad news anyway. Sounds like it was time for nice, fresh pots. :)

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