This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc. Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease SymptomsWhat testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease ScreeningInterpretation of Celiac Disease Blood Test ResultsCan I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful?The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-FreeIs celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic TestingIs there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and DisordersIs there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients)Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients)Gluten-Free Alcoholic BeveragesDistilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free?Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free DietFree recipes: Gluten-Free RecipesWhere can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.For Additional Information: Subscribe to: Journal of Gluten Sensitivity
Just a word on vitamins and minerals. Most are not absorbed efficiently in people with "normal guts" so I recommend minerals in the chelated form. They are bound to amino acids and dissolve easier. Stay away from minerals linked with phosphates or oxides, ie calcium phosphate, magnesium oxide and cupric oxide. These are all very poorly absorbed.
also stay away from tablets with high amounts of magnesium stearate. Look for liquids or softgels or quick dissolving tablets. I usually buy my vitamins at the health food store, but you still need to read the labels!
"what you don't know may be killing you" by Don Colbert, MD is a great resource for living healthier. Check it out!
With only a positive IgG it is possible you are glten sensitive without haveing any damage to your intestines at this point, so don't be surprised if your biopsy comes back negative. The gliadin Iga and TTg IgA will only come back positive once damage has occurred, so these are the blood tests the docs use for diagnosis. (Unless, like stated above, you have a total IgA defficiency)
Just an interesting note to all, one of the reference labs my facility uses actually has lower cut off values for the celiac panel. You can look up www.specialtylabs.com and you will see thier reference ranges for the gliadin IgA and the TTg IgA are less than 5! Why is this when they use the same methodology as the other labs who state <20 as being negative? I'm not sure so I have sent them an e-mail and have asked for supporting documentation. I am very curious and will post when I receive the info.
My daughter tested a 68 for the IgG, but like you is only positive for the other markers according to Specialty labs' guidelines. Shee feels better gluten free, but can't stay on it for any length of time due to visitation at her dad's, so I am very anxious to find documentation stating she could benefit from a gluten-free diet, just so her dad will also agree to try it.
Please let us know if they find celiac with the biopsy, I know there are others in the same boat who would like a definative answer about IgG only results.
A friend of mine is involved with a company called juiceplus. They are actually a "whole food source" rather than a manufactured vitamin. I just received the packet in the mail and will be ordering shortly.
They carry capsules for adults, chewables for kids and even a gummi bear, with NO ARTIFICIAL SWEETENERS! If you would like more info, check out www.juiceplus.com and take the tour!
I can also direct anybody who's interested to my friend, david's direct e-mail or can forward info he has already sent me about the products.
You order a 4 month supply, but can pay in monthly installments. I think the kids' varieties are about $22 / month. They also have an offer where each paying adult can get a free supply for the kids, but I'm not sure if this is still available. I can check.
Hi! The IGA 266 is your total IGA, which is in the normal range. The TTg is the tissue transglutaminase which is the newest test for celiac disease and is directly proportional to the amount of damage in your intestines. Your TTg was normal. (less than 20). From my experiences and research I believe a person can have an intolerance to gluten either before damage occurs or stay gluten intolerant with no adverse affects. I've done some reading on the gliadin IgG which you might want to consider being tested for.
The usual celiac panel consists of the gliadin abs-IgG and IgA, the TTg IGA and the reticulin abs, these last are really not very useful and most docs these days are just going with the TTg and a total IGA to make sure you don't have an IGA deficiency which is fairly common in celiacs.
I would suggest that you ask your doc for the gliadin abs and ask him if the IgG comes back positive, should you try gluten free. Many people on this site have positive IgG only yet respond well to a gluten-free diet. The good news is, if you mess up and ingest gluten, you will feel sick with the usual symptoms but there are no circulating IgA abs causing damage to the intestines.
I understand you are concerned about your doctor's conclusions regarding your daughters gliadin "scores". However you are actually very lucky to have such a knowledgeable and open minded physician. My daughter's drs. have stated there is nothing wrong and nothing to worry about, even though her gliadin IgG was 68. Her total Iga was slightly decreased but not enough to be considered a true deficiency. She responds well to gluten-free diet, however her dad refuses to try gluten-free without a dr's order and diagnosis and she spends half of her time with him as we are divorced! So count your blessings!
As to other facors to increase the gliadin IgG, according to the labcorp manual: ...False positives are possible as other gastrointestinal disorders are known to induce circulating antigliadin antibody, mainly Crohn disease, food protein intolerance, and postinfection malabsorption."
Usually the doctor can easily rule out Crohn's and infection by symptoms and a CBC which is usually done along with the celiac screen to check for anemia. That leaves food intolerance. Most probably to wheat, though many celiacs also have intolerance to lactose, and less frequently soy products and/or yeast. Whether these other intolerances would increase the gliadin or if the gliadin is strictly specific to wheat, I'm not sure.
Also, the tissue transglutaminase or ttg-iga will only be elevated once damage has occurred to the intestines. It is possible to be sick or have a reaction to gluten without it actually causing damage. (Similar to the fact that my daughter has diarrhea every time she eats peaches, but that doesn't mean damge is occurring.)
Hope this helps. Keep the faith...
PS Labcorp stands for lab corporation of America and is one of the labs our office uses to test for celiac.
Thanks so much for sharing! What exactly is vitiligo? My daughter has bumpy almost leathery skin on both of her upper arms. Has had it her whole life. One time she also had some kind of outbreak on the inside of her elbow, lasted for weeks. The school nurse kept sending her home, even though the doc said it was not contagious. We all called it "Oozy-goozy disease" just for fun, but I suspect it may have been dermatitis herpetiformis. However her total IgA was slightly below normal, but not low enough to be considered a true deficiency.
Would your pediatrician's office have any documentation, or could I contact them for information regarding followup and possible treatments for positive gliadin IgG? You can send it to firstname.lastname@example.org or post it here, if you're willing and it's OK with the office.Maybe I could share it with the docs in our office, I work in the building and I'm sure they would entertain and review any info I could give them coming from other physicians.
My daughter also tested positive for only the Gliadin IgG. (69) There is celiac disease in my family so we went to a "specialist" all the docs said it is nothing-maybe IBS or stress. I tried the gluten-free diet, and after 1 week, she did notice an improvement in stomache aches and # of trips to the bathroom. Have you or your son noticed any improvement yet? From what I've read, if there is no damage or minimal damage to the intestines, improvement should be noticed quickly once beginning a gluten-free diet.
She spends about half the time with her dad, (we are divorced) and dad won't try the gluten-free without a doctor's recomendation. I understand that a person can be gluten sensitive, but not have full blown celiac disease. I'm wondering if having only IgG is the same as "early detection" In other words, if you're sensitive and continue to ingest gluten, are you at a higher risk to eventually damage your intestines and develop full blown celiac disease?
If you find any docs who are willing to treat or recommend a gluten-free diet for you or your children, I would love to know. My daughter-age 12, is sick everyday, but just tolerates it. On a scale from 1-10 she is at least a 6 everyday, but now only complains when she is around 8 and really can't function.
PS-I also had her tested by enterolab and their results stated that she is sensitive to gluten, but there is no damage based on the fact her absorption was normal.
I'm glad to know there are people in the same boat as we are!
Thanks for all the replies! As far as enterolab, they are accredited and their methods are valid. I think the main reason doctors don't accept the diagnosis is there is not enough data at this point to validate their "normal values" which are less than 10 units. As you all know, the blood serum reference ranges are usually less than 20. So while the methods are valid, there is still some question in the medical community about the interpretation of the results. I'm pretty sure my daughter has at the least a gluten sensitivity, and I for one agree with enterolab"s findings. I didn't have the gene testing done because my aunt definately has it and I'm pretty sure my mom and both sisters do to. They have refused testing.
Thanks again, after reading all the replies I will definately keep pursuing a daignosis. I may also check my son-age 9 who has been diagnosed with depression and has borderline ADD through enterolab. He also has mild tourette syndrome. Maybe a gluten-free diet would help him, too. Last year his celiac screen came back negative. We also use quest labs.
My daughter also came back high on the IgG and negative on the Iga. She is 11 and has 3-4 BMs/day. She misses an average of 2 days/month of school due to nausea, stomache aches and severe headaches. All other screening blood tests came back negative. I went ahead and had her tested at enterolab and she came back positive for both TTg and Gliadin, but no intestinal damge-yet. Her primary did refer us to a specialist, but he diagnosed her as having IBS or stress. Does your daughter get sick often? My daughter seems to be a magnet for strep and any ailment she does get seems to be worse and longer lasting than for other kids. I don't want to go gluten-free unless I have to, but she did improve when I tried it. Any ideas as to what else could cause the gliadin IgG to be elevated, if not a reaction to gluten-on some level?