I read the posts about nightshade with great intrest. About two year ago I started getting a skin rash on my neck when eating tomatoes which progressed into rash + irritated throat to restricted breathing and now to wheezing. I also started reacting to cayenne pepper, chillies, and papreeka (which is in everything). Though, unlike the other posts I can eat potatos with no problems. It takes me 3-4 days before I am well again after eating the nightshade, and because of the breathing problems I've gone to urgent care. The allergist told me that it was a food intolerance, but probably wasn't totally convinced because he said that I should still go to the emergency room in case it was anaphylaxis. It was through this whole process that I determined that I have problems with gluten. The allergist asked me if I had heartburn. I said yes and followed his advise to take prylosec and quit caffeine. It didn't help and I noticed that my upset stomach and reflux often occurred after eating bread. So I went without for a week and all my stomach problems went away. However I am still growing increasingly sensitive to nightshades (except potato).