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  1. I had the capsule endoscopy done, because I had a mild anemia as well. I do have some positive celiac antibodies as well (TTGA about 30 and Gliadin Igg about 40-45), but two endoscopies had negative biopsies. The capsule endoscopy was to look for ulcers or Chrohn's, but my GI doctor said sometimes they can see celiac as well. My capsule endoscopy showed some blunting of villi in the beginning of the small intestine. So for me, I think it was quite valuable. I'm trying the gluten-free diet for 9 months while my blood tests are being monitored. I would definitely eat wheat for a good while before the test, though, because that way any villi abnormalities may be picked up.
  2. I must be DQ7.5, since Prometheus reported I have DQA1 05, half the heterodimer (and DQ2 and DQ8 negative). From what I can tell the only possibility would be DQA1 05 - DQB1 03, which is DQ7.5.
  3. The 4 celiacs with no part of dq2 heterodimer break down as follows: DQ5/DQ5 DQ4.4/DQ5.1 DQ4.4/DQ5.1 DQ7.3/DQ9.2 Sorry, no DQ6. But with only 4 samples, I don't know if you can draw any conclusions. With DQ2.2, it depends what is paired with. DQ2.2/DQ2.5 can produce the DQ2.5 heterodimer and 50% of the produced isoforms are dq2.5. DQ2.2/DQ7.5 can produce the DQ2.5 heterodimer and 25% of the produced isoforms are dq2.5. DQ2.2/DQ2.2 can NOT produce the DQ2.5 heterodimer, but produces 1/2 (Beta subunit) of it. In the article, there were actually more DQ2.2/DQ5 (14) than DQ2.2/DQ2.2 (11), and more DQ7.5/DQ5 (6) than DQ7.5/DQ7.5 (3). So after the DQ2, DQ8, and the 1/2 heterodimer (DQ2.2 and DQ7.5), it appears DQ5 is next in being prevelent.
  4. Thank you for the great article on haplotypes of celiacs. Here are some statistics from the 1008 celiacs from Europe. DQ2 positive 88% DQ8 only 6% DQ2 and DQ8 negative 6% (1/2 DQ2 heterodimer) no part of DQ2 heterodimer 0.4% (4 out of 1008 celiacs). Of the 1/2 DQ2 heterodimer celiacs: Alpha subunit 28% Beta subunit 72% The Alphas all have DQ7.5, of these 19% are homozygous (DQ7.5/DQ7.5). The Betas all have DQ2.2, of these 27% are homozygous (DQ2.2/DQ2.2). Of the 1/2 DQ2s that are heterozygous, the other haplotypes break down as: DQ4 9% DQ5 47% DQ6 21% DQ7 5% DQ9 19% Of the four celiacs that had no DQ2 or DQ8 association, three had a DQ5 haplotype. What suprises me about the data, is that a good percentage (28%) of the 1/2 DQ2 celiacs had the alpha subunit. Everything I had read said the Beta unit was much more important, and that the alpha subunit types (which is me) was much rarer than the Beta type. This data definitely does not say that. This data is starting to make me dizzy, time to party. Happy New Year !!
  5. Thank you for the link about DQ7.5. I have a science background, and it's fascinating for me to read about these genes and their proteins, even though some of the details are hard to grasp. I'm going to research DQ7.5 celiac to see if there are any particular presentations associated with it. If anyone has any special knowledge, please chime in. Thanks.
  6. Thank you for your reply. I do not have a specific haplotype (?) result. All I have from Prometheus is that HLA DQA1 05 was detected, and that I am DQ2 and DQ8 negative. They state that some celiacs do have half the DQ2 heterodimer. Your reply confirms my reading in that most half DQ2 celiacs have the beta subunit and that celiacs with the alpha unit only are rare. I have had two biopsies done (one with a longer scope) and both came up negative. A capsule endoscopy showed some villi that appeared blunted, but they looked more normal the further you went down the small intestine, and a comment on the report said this COULD be an atypical celiac presentation. Also, the reason I had the celiac antibodies done in the first place was that I had some elevated liver enzymes most likely related to a minocycline induced hepatitis. In the liver doctor's workup she ran the celiac panel. I also have had a chronic inflammation pattern on the serum electrophoresis with IGG level at one point around 4,000, but now down to about 2,400 (still elevated). They also showed small monoclonal spikes, so I was worked up for myeloma, but that has come back negative, thank god. The liver enzymes have come back to normal, but they were normal before the diet started. I guess one concern I have is it possible the chronic inflammation I have giving some false positive celiac antibody tests, or is it more likely it's related to celieac disease. My doctors have so far been kind of stumped and they hope the celiac diagnosis will tie things together.
  7. Hi all, I'm a newbie to the forum, thank you already for the valuable information I've read from this web site. I'm currently in the middle of a nine month gluten free diet, and drawing blood every few months for the antibodies. My question is about the genetic profiles. I am HLA-DQ2 and HLA-DQ8 negative, but positive for the HLA DQA1 05 allele. My understanding is that to get celiac with this profile is rare, and that when someone has celiac with half the DQ2 heterodimer it is most often with the Beta subunit, not the alpha (which I have). Does anyone else have this profile with being positive for only the alpha subunit? After 4 months of the diet, my TTGA has stayed around 25 (in the past it's been 25-35). My gliaden IGG in the past has been in the 40's, after 1 month it was still in the 40's, and after 4 months it became negative. The vague GI symptoms I've had have improved since being on the diet. No more foul smelling gas or BM's. I've never had diarrhea. Thank you.