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val01

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About val01

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  1. Hi Nora, Enterolab did my testing. I was debating whether I wanted to pay to have Promethus to do the DQ2/DQ8 test. I am very confused about my DQ 1,4 result as I am Irish, German, and British. When I asked about the DQ4, I understand that it's not limited to Asians but it's uncommon in Caucasians - and it's uncommon for with my ethnic background not to have at least one DQ2/DQ8 from what I understand. I was thinking perhaps there was an error maybe. A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value Fecal Anti-gliadin IgA: 17 Units Fecal Anti-tissue Transglutaminase IgA: 10 Units Quantitative Microscopic Fecal Fat Score: Less than 300 Units Fecal Anti-casein (cow's milk) IgA: 8 Units HLA-DQB1 Molecular analysis, Allele 1: 0502 HLA-DQB1 Molecular analysis, Allele 2: 0402 Serologic equivalent: HLA-DQ 1,4 (Subtype 5,4) I have never heard of anyone having the DQ8 on the alpha side - just a half of a DQ8, like the DQ2 halves you hear about. I have read through Wikipedia on DQ4, DQ1. I also found this link - http://www.twinsuk.ac.uk/Publicatons/2008/ErlichH.Diabetes.%202008.pdf I know this references diabetes, but I was mainly looking at the allelle patterns on Page 3. For example, you can have DQA1*0301, DQB1*0402 or DQA1 *0401, DQB1*0402 for DQ4, and for DQ1 - DQA1 *0102, DQB1 *0502. So, if you had DQA1*0301, could you have a half of DQ8 on the alpha side? I hope I am making sense. Thank you for assistance. Valerie
  2. Hi All, I think that my subject topic covers my question. Can you have a half of a DQ8 (really asking on the alpha side)? Thanks so much! Valerie
  3. Hello All, I am new to the forum. I am hoping to gain some insight into my situation. I had my 2nd baby in June 2009. I felt like crap after that. It was more than post partum tiredness. Finally, after much to do - my OBGYN tested my thyroid, and sure enough I am very hypothyroid (TSH 9.98). So, I get put on meds, and not feeling much better. I start tracking my food. I narrow it down to "bread" that is making sick. MY PCP diagnoses me with Hashimotos and runs the celiac panel which is negative. I go through Enterolab and get this - A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value Fecal Anti-gliadin IgA: 17 Units Fecal Anti-tissue Transglutaminase IgA: 10 Units Quantitative Microscopic Fecal Fat Score: Less than 300 Units Fecal Anti-casein (cow's milk) IgA: 8 Units HLA-DQB1 Molecular analysis, Allele 1: 0502 HLA-DQB1 Molecular analysis, Allele 2: 0402 Serologic equivalent: HLA-DQ 1,4 (Subtype 5,4) So, I see my PCP today and give him my Enterolabs. He's honest and says he has no idea what he's looking at or if it's credible. He asks me what about my negative blood test - and then says, ' maybe you need the biopsy?' I make an appt with a GI doc who is with the CS Association. Should I have the biopsy? I am not sure what it's going to do - other than a label. I have been gluten-free for 2 weeks and feel better with no GI symptoms. Of course, to do the biopsy, I have to go back on gluten. So thoughts? Also, have a gene related question. So, my alleles are posted above. I think that I am DQ1 and 4. Is it worth getting the alpha chain tested too? Or, do those two alleles not have a celiac/gluten sensitive association given my beta chains?? I hope I am making sense! Thanks in advance. I am a bit overwhelmed with this. Valerie
  4. A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value Fecal Anti-gliadin IgA: 17 Units Fecal Anti-tissue Transglutaminase IgA: 10 Units Quantitative Microscopic Fecal Fat Score: Less than 300 Units Fecal Anti-casein (cow's milk) IgA: 8 Units HLA-DQB1 Molecular analysis, Allele 1: 0502 HLA-DQB1 Molecular analysis, Allele 2: 0402 Serologic equivalent: HLA-DQ 1,4 (Subtype 5,4) ********** So, can someone help me understand the genetics part? Do I have DQ 1 & 4, or 5 &4? Either way, I know '4' isn't associated with gluten sensitivity, however is it only found in Asians or Native Americans? I am very curious about this as I have my proven genealogy and it doesn't fit. Thanks in advance, Valerie