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    • Frequently Asked Questions About Celiac Disease   09/30/2015

      This FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Store. For Additional Information: Subscribe to: Journal of Gluten Sensitivity


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  1. "Anti-GAD antibodies target an enzyme called Glutamic Acid Decarboxylase. This enzyme is responsible for converting glutamic acid to GABA, a chemical found in high concentrations in the cerebellum of the brain. Anti-GAD antibodies are particularly common in diabetes mellitus and autoimmune diseases such as thyroid disease and rheumatoid arthritis." There is some interesting research in mice using GABA (a supplement which is commonly used in sports fitness and health) for type 1 diabetes. GABA Therapy Prevents Type 1 Diabetes and Reverses Established Disease in Mouse Models It makes sense that people who have anti-GAD antibodies may be deficient in GABA, which can lead to symptomatic health problems. Taking a GABA supplement may restore this deficiency and improve symptoms.
  2. What test did you do? Do you have IgA deficiency? If you don't do all of the right tests, Celiac disease may not be detected accurately. Immunoglobulin A (IgA) Deficiency and Alternative Celiac Disease-Associated Antibodies in Sera Submitted to a Reference Laboratory for Endomysial IgA Testing Immunoglobulin A (IgA) deficiency occurs more frequently in patients with celiac disease (celiac disease) than in the general population and can lead to false-negative results in the best serologic test for celiac disease, endomysial IgA (EMA). Celiac Disease and Immunoglobulin A Deficiency: How Effective Are the Serological Methods of Diagnosis? Immunoglobulin A (IgA) deficiency is 10 to 15 times more common in patients with celiac disease (celiac disease) than in healthy subjects. IgG-specific antibody tests for endomysium, gliadin, and tissue transglutaminase are useful for the identification of IgA-deficient patients with celiac disease. IgG antibody tests along with tests routinely being used in clinical laboratories can reliably detect all active patients with celiac disease. In addition, the levels of these celiac disease-specific IgG antibodies could be used to monitor patient dietary compliance. But either way a grain-free diet is probably a good idea.
  3. I believe that anyone would be doing themselves a disfavour by eating (unfermented) grains, especially those containing gluten. Whether it's ulcerative colitis, Crohn's, celiac disease etc, gluten is potentially a major cause contributing to many different disease symptoms. In my case, I'm IgA-deficient. My IgA has been 10 mg/dl (reference range 90-400 mg/dl) on the last 3 occasions, and my IgG is elevated and has ranged from 1930 to 2173 mg/dl (reference range 820-1740 mg/dl). Celiac Disease and Immunoglobulin A Deficiency: How Effective Are the Serological Methods of Diagnosis? ABSTRACT Immunoglobulin A (IgA) deficiency is 10 to 15 times more common in patients with celiac disease (celiac disease) than in healthy subjects. Serological tests have become the preferred methods of diagnosing celiac disease in both symptomatic and asymptomatic patients. However, commercially available serological methods are limited in that they detect only the IgA isotype of antibodies (with the exception of IgG gliadin assays); hence, IgA-deficient patients with celiac disease may yield false-negative serology. Fifteen pediatric patients with celiac disease and 10 IgA-deficient pediatric patients without celiac disease were examined for IgA and IgG antibodies to endomysium, gliadin, and tissue transglutaminase. Twenty-five specimens from patients with IgA deficiency were examined. Fifteen were from patients with celiac disease, and 10 were patients without celiac disease. All 15 IgA-deficient patients with celiac disease were positive for endomysium antibodies of the IgG isotype and for IgG gliadin antibodies. All but one of the IgA-deficient patients with celiac disease were also positive for IgG tissue transglutaminase antibodies. None of the IgA-deficient patients without celiac disease were positive for any of the antibody markers. All the specimens examined were also negative for IgA-specific antibodies to endomysium, gliadin, and tissue transglutaminase. IgG-specific antibody tests for endomysium, gliadin, and tissue transglutaminase are useful for the identification of IgA-deficient patients with celiac disease. IgG antibody tests along with tests routinely being used in clinical laboratories can reliably detect all active patients with celiac disease. In addition, the levels of these celiac disease-specific IgG antibodies could be used to monitor patient dietary compliance. (extracts) Delays in the diagnosis of celiac disease may increase a patient
  4. And importantly I think we want to know if there is an autoimmune response, so various blood tests make a lot of sense and are much more practical than endoscopy and taking biopsies. I tend to have a lot more to do with cancer, where I'm very cautious about biopsies, especially in places like the digestive system.
  5. Let us know if you learn more about your tests that might explain things more clearly. When I first stumbled upon the Anti-GAD Antibodies test and read that it was a predictor of (type 1) diabetes, I did the test without any idea what to expect. But the positive results provided me with very important information, so it was very lucky.
  6. If you have always had trouble regulating blood sugar, wouldn't that indicate you have some sort of diabetic condition? Have you ever checked Anti-GAD Antibodies and Anti-IA-2 Antibodies? Also testing your blood Insulin and C-Peptide levels would indicate your insulin production. If your non-fasting insulin and c-peptide levels are low then you'll have trouble controlling blood sugar, as I do. ZTT is a simple test related to total immunoglobulin (especially IgG) and high levels can indicate chronic and autoimmune diseases. My ZTT is slightly elevated and my total IgG is elevated. You can also do tests for Insulin Antibodies. My ICA-IgG test was also positive, but everything else negative. Definitely the grain-free, fruit-free diet is a good idea to stick with.
  7. Yesterday I received a copy of Dr Bernstein's Diabetes Solution, 4th Edition which just came out. It looks very good and I read some parts, especially about Low Dose Naltrexone (LDN) where he also recommends 4.5mg Naltrexone at bedtime, and which he sometimes uses for his patients. I think there is a lot still to be learnt about endorphins and how LDN stimulates their production in the body. In the mean time LDN is a safe drug with a long history of use that is being prescribed by more and more doctors at this very low dose without any problems.
  8. A vitamin C supplement with meals might be a better way to increase iron absorption without any side effects. "Vitamin C promotes iron absorption in the small intestine.15 Vitamin C enhances absorption of soluble nonheme iron, either by reducing it or preventing its chelation by phytates or other food ligands. Vitamin C increases iron absorption 1.5- to 10-fold, depending on iron status, the test meal, and ascorbate dose. Iron absorption can be doubled by 25- to 50-mg ascorbate in the meal, and ascorbate can double iron absorption in iron-deficient patients" As mentioned in the article, phytates are a real problem for iron absorption, so you should avoid unfermented soy foods and other grains which are high in phytic acid. But according to the research vitamin C will help reduce the chelation of iron by phytates. For children, sodium ascorbate powder can be easy to take in some water. Otherwise Ascorbic Acid in a capsule or tablet. I avoid chewable vitamin C or acidic powder because it may not be good for the teeth because of the acidity. If you can't get Sodium Ascorbate, you can make it simply by combining pure Ascorbic Acid powder with about an equal amount of Baking Soda (Sodium bicarbonate). Adjust the amount of baking soda according to the acidity level you want.
  9. I think Low Dose Naltrexone (LDN) could be very important in the treatment of autoimmune diabetes as well as allergies. In other diseases I've heard doctors report that they get better results with LDN when patients avoid carbohydrates. Many people also report problems with candida yeast overgrowth when they eat the white carb foods. Butter and coconut oil would be very important foods in a low carb diet, to supply enough calories for energy and suppress hunger. Butter contains a great number of nutrients, such as Choline, vitamin A, E, and K, without the lactose found in milk. I'll have to look into Casein allergies more, but generally it seems many people have problems with pasteurized milk which lack of enzymes. I've been avoiding milk and only eat natural yoghurt which I make myself from organic non-homogenized milk I know a Bromelain/Quercetin combination is effective as an anti-histamine, so it could be helpful to reduce other allergies. Vitamin C is also a natural anti-histamine which works well in combination with Bromelain and Quercetin. I've seen this combination nearly completely control serious seasonal pollen allergies which didn't respond well to anti-histamine drugs. Natural Vitamin A, such as from fish liver oil, is an immunomodulator, which may help too. For example, a quick search finds an example (although in animals) how vitamin C acts as an immunomodulator that attenuates anaphylactic reactions to soybean glycinin hypersensitivity. I have also read how high dose vitamin C can be effective in people with anaphylactic shock from bee stings. I always take a liquid cod liver oil supplement which supplies about 1000mg EPA and DHA, and 10,000 IU vitamin A. There is good evidence that fish oil helps reduce allergies. I prefer cod liver oil over fish oil because it contains the all important natural vitamin A and some vitamin D too. "Dietary supplementation with fish oil in anti-inflammatory doses inhibits prostaglandin E2 (PGE2) synthesis by stimulated peripheral blood monocytes. This provides a mechanistic basis for the reduction in non-steroidal anti-inflammatory drugs (NSAID) requirements in patients taking anti-inflammatory doses of fish oil." There is also an interesting study here on high dose vitamin E. High-Dose Vitamin E Supplementation Normalizes Retinal Blood Flow and Creatinine Clearance in Patients With Type 1 Diabetes The researchers used 1800 IU vitamin E per day in this trial which may be excessive for normal people, but it might be appropriate for people with type 1 diabetes to prevent complications. This appears to be good clinical research which shows a clear benefit in people with type 1 diabetes. The blood vessels in the eyes are excellent diagnostic indicators of diabetes and other diseases.
  10. This is interesting too and there is hope. She is very young and probably lacks experienced support. Either way, this diet may not be enough on it's own, or at least it would be much more challenging and require a lot of effort to work everything out. Regular diagnostics and lab testing would also be necessary. I'm going to stay on a very low-carb, gluten free diet which I was on already before I discovered the high anti-GAD antibodies. The way I stay on low carbs is to include plenty of calories from fats such as butter and coconut oil. But I'm also trialling a number of anti-diabetic agents, such as Cinnamon, Gymnema sylvestre, Bitter Melon, Fenugreek, Chromium GTF and Vanadium (as bis-glycinato-oxo-vanadium - organic form of vanadium) and Alpha Lipoic Acid. I use these in combination, because single agents don't generally appear to have enough effect, or the doses need to be too high. Currently I'm taking these for the diabetes: 3600 mg Cinnamon 1800 mg Gymnema sylvestre 1200 mg Bitter Melon 3000 mg Fenugreek 4800 mcg Chromium GTF 24 mg Vanadium (as bis-glycinato-oxo-vanadium)* 1200 mg Alpha Lipoic Acid 4.5 mg naltrexone - LDN (at bedtime) Usually I take these in 3 divided doses with meals. * This form of vanadium is quite different from other forms and the dose is different too. I'm doing a lot of what is covered here, with the use of supplements as well as diet to get the desired results.
  11. Canola Oil

    Generally vegetable oils are highly processed and go rancid very quickly, even before you buy them. This is because they are low in saturated fat. For example, coconut oil is high in saturated fat, which gives it a long shelf life and makes if good for cooking with. If one gets over the whole "saturated fat is bad for you" nonsense, then there is no problem. Most people also don't realise that animal fats are not only saturated fat, but often contain large amounts of other fatty acids such as monounsaturated fatty acids, the same as what you find in olive oil. The fats in animal foods also contain the fat soluble vitamins (such as vitamin A, D, E, K), so removing the fat will have a negative impact on vitamin content of the food and so it's health benefits. Also butter, coconut oil and macadamia oil for example is very low in Linoleic acid (an omega-6 fatty acid), which is very high in most vegetable oils. A high ratio of omega-6 to omega-3 fatty acids in the diet accentuates omega-3 fatty acid deficiency. This is a common problem in modern western diets that are high in vegetable oils now.
  12. Exactly. No gluten would be important in the case of celiac disease. But generally I think a non-grain diet is probably a good idea for everyone, since grains contain phytic acid which unless the grains are prepared properly would cause digestion issues which aren't ideal for good health and mineral absorption. It's very common for people with celiac disease, and other diseases in general to be deficient in zinc and have elevated levels of copper. There is some evidence that depleting the body of copper and improving zinc status can improve things. Zinc among other things is necessary for insulin production. Zinc, Insulin and Diabetes In my case I can only keep my blood zinc level in the normal range by taking around 100-150mg of zinc a day. That gives me a blood zinc level of around 100 mcg/dl (normal range 59-135 mcg/dl). 50 mg/day zinc will only just put me in the normal range. By comparison my copper level tends to be around 130-135 mcg/dl (normal 66-130 mcg/dl). With disease progression it's common for copper levels to continue increasing, especially with a lack of zinc in the diet I guess.
  13. You mean type 1 diabetes and celiac disease are both autoimmune diseases.. Glycemic control such as through diet (low carb) seems to delay onset of LADA even though it's autoimmune.
  14. I've known I had gluten allergy for a few years when my sister was diagnosed with it. In the last couple of years I found I did well on a low carbohydrate, high fat diet which I've been sticking to. I was gluten free, except for long-rise sourdough bread I was making myself. Then recently I was doing some blood testing and I also found I had anti-GAD antibodies. My levels were pretty high at 358 U/ml. My total IgG is elevated and my IgA and IgE levels are below normal. I'm still producing small amounts of insulin and my C-peptide levels are ok, so I'm trying to slow the progression of LADA. Currently my HbA1c is at 6.4%. After I got the results for IgG and IgA I decided to also stop eating sourdough bread and so eliminated wheat completely from my diet. I came across Dr Richard Bernstein in my searches, and pre-ordered the new edition of his book coming out in November. I'm looking forward to reading it. I'm using low dose naltrexone (LDN) in combination with the diet etc to see if I can improve the autoimmine component and also reduce my HbA1c level back to normal again. So far my anti-GAD antibodies is down to 276 U/ml in 2 months, but I'll have to track it longer to see if this trend continues.