I have suffered with colon problems all my life. I get very sick and end up with diarrhea. I now am deficient in Vit B12, Vit D and have been iron deficient anemia. It was so severe they was going to give me blood transfusions, but I opted for the iron infusion. I have had the blood test ran for Celiac's and it came back negative. I'm going to go gluten free to see if that helps. This is awful to have because when you have the attacks you are restricted to home close to the bathroom and wears me out.