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Celiac.com 05/03/2021 - Some research data suggests that a vegan diet may be associated with impaired bone health. To get an idea of the potential impact of a vegan diet on bone mass, a team of researchers recently set out to investigate the associations of veganism with calcaneal quantitative ultrasound (QUS) measurements, along with the investigation of differences in the concentrations of nutrition- and bone-related biomarkers between vegans and omnivores. Scientific evidence suggests that a vegan diet might be associated with impaired bone health. The team used a cross-sectional study of 36 vegans, and 36 omnivores to assess the associations between a vegan diet and calcaneal quantitative ultrasound (QUS) measurements, along with comparing concentrations of nutrition- and bone-related biomarkers between vegans and omnivores. The data showed lower QUS parameters in vegans compared to omnivores. For example, broadband ultrasound attenuation shows a low QUS parameter of 111.8 ± 10.7 dB/MHz for vegans, compared with 118.0 ± 10.8 dB/MHz for omnivores. Compared with omnivores, vegans had lower levels of vitamin A, B2, lysine, zinc, selenoprotein P, n-3 fatty acids, urinary iodine, and calcium, but higher concentrations of vitamin K1, folate, and glutamine. Applying a reduced rank regression, the team found 12 out of the 28 biomarkers that contribute most to bone health, including lysine, urinary iodine, thyroid-stimulating hormone, selenoprotein P, vitamin A, leucine, α-klotho, n-3 fatty acids, urinary calcium/magnesium, vitamin B6, and FGF23. They found that all QUS parameters rose across the tertiles of the pattern score. The study offers evidence of reduced bone health in vegans compared to omnivores, in addition to highlighting a combination of nutrition-related biomarkers, which may reduce bone health. The team calls for additional studies to confirm these findings. Since a number of studies have shown celiacs to be at greater risk for reduced bone health, especially bone density, bone health is a major concern for people with celiac disease. Learning more about the role of diet in improving bone health will benefit celiacs and non-celiacs alike. Read more in Nutrients 2021, 13(2), 685. The research team included Juliane Menzel, Klaus Abraham,Gabriele I. Stangl, Per Magne Ueland, Rima Obeid, Matthias B. Schulze, Isabelle Herter-Aeberli, Tanja Schwerdtle, and Cornelia Weikert. They are variously affiliated with the Department of Food Safety, German Federal Institute for Risk Assessment in Berlin, Germany; the Institute for Social Medicine, Epidemiology and Health Economics, Charité, Universitätsmedizin Berlin in Berlin, Germany; the Institute for Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany; the Section for Pharmacology, Department of Clinical Science, University of Bergen in Bergen, Norway; the Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg, Germany; the Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam–Rehbruecke, Nuthetal, Germany; the Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany; the Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zurich in Zurich, Switzerland; the German Federal Institute for Risk Assessment, Berlin, Germany; and the Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam in Nuthetal, Germany.

Celiac.com 05/01/2018 - Celiac disease is marked by a variety of intestinal and extra-intestinal symptoms. One of the most common and best described expressions of celiac disease outside the gut is the presence of osteopenia and osteoporosis, which make for a higher fracture risk. A team of researchers recently set out to see if a gluten-free diet (GFD) improves bone mineralization. The research team included MB Zanchetta, AF Costa, V Longobardi, R Mazure, F Silveira, MP Temprano, H Vázquez, C Bogado, SI Niveloni, E Smecuol, ML Moreno, A González, E Mauriño, JR Zanchetta, and JC Bai. They are variously associated with the Instituto de Diagnóstico e Investigaciones Metabólicas, Buenos Aires, Argentina; Research Institute, Universidad del Salvador, Buenos Aires, Argentina; the Department of Medicine, Dr C. Bonorino Udaondo Gastroenterología Hospital, Buenos Aires, Argentina; and with Consejo de Investigaciones en Salud, Health Ministry, Buenos Aires City Government, Buenos Aires, Argentina. These researchers previously identified a significant deterioration of bone microarchitecture in premenopausal women with newly diagnosed celiac disease using high‐resolution peripheral quantitative computed tomography (HRpQCT). In that study, the team also compared 1‐year results with those of a control group of healthy premenopausal women of similar age and BMI in order to assess whether the micro-architectural parameters of treated celiac patients had reached the values expected for their age. While that study showed that a year on a gluten-free diet had improved most of the women’s bone parameters, it also showed that those parameters continued to be significantly lower than those of healthy control subjects. In a recent paper, the team describes the results of their study that offers data to show improvements bone mineralization microarchitecture in celiac patients after three years on a gluten-free diet. Source: Clin Gastroenterol Hepatol. 2017 Oct 6. pii: S1542-3565(17)31200-4. doi: 10.1016/j.cgh.2017.09.054.