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Celiac Disease & Gluten-Free Diet Blogs

  • kareng's Blog
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  • An Unmistakeable Journey
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  • The Patient Celiac
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  • Trials and Tribulations
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  • Research on South African Celiac Tours
  • lindylynn's Blog
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  • Melissa.77's Blog
  • Keating's Not-so-Glutenfree life
  • AmandasMommy's Blog
  • Coeliac, or just plain unlucky?
  • bandanamama's Blog
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  • Ellenor Whitty's Blog
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  • Scott's Celiac Blog
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  • Silly Yak 08's Blog
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  • Searchin for a Primary Care Dr. In Redlands That is Knowledgeable about Celiac disease
  • num1habsfan's Blog
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  • Celiac-Positive
  • Jason's Mommy's Blog
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  • Lauren Johnson's Celiac Blog
  • I love my plant Cactus <3
  • Chele's Blog
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  • What I've Learned
  • Da Rant Sheet
  • Michael Fowler's Blog
  • Living in Japan with Ceoliac Disease
  • mkmaren's Blog
  • MJ
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  • Joe pilk
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  • HONG KONG GLUTEN, WHEAT FREE PRODUCTS
  • Guth 101's Blog
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  • Gail Marie's Blog
  • Healthy Food Healthy You
  • SydneyT1D - Diabetic and Celiac YouTuber!
  • GFGF's Blog
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  • SMAS: www.celiac.com
  • gardener1's Blog
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  • JordanBattenSymons' Blog
  • JillianC
  • Sugar's Blog
  • Blanche22's Blog
  • Jason's Blog
  • Gluten-Free Sisters :)
  • Eab12's Celiac Blog
  • ohiodad's Blog
  • Newly Self Diagnosed?
  • misscorpiothing's Blog
  • anshika_0204's Blog
  • Petroguy
  • abqrock's Blog
  • WhoKnew?'s Blog
  • Soap Opera Central
  • nurcan's Blog
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  • Mr J's Blog
  • Rachel Keating's Blog
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  • krisb's Blog
  • deetee's Blog
  • CAC's Blog
  • EmilyLinn7's Blog
  • Teri Kiefer's Blog
  • happyasabeewithceliac's Blog
  • quietmorning01's Blog
  • jaimekochan's Blog
  • Cheryl
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  • donna mae's Blog
  • Colleen's blog
  • DawnJ's Blog
  • Gluten Challenge
  • twins2's Blog
  • just trying to feel better's Blog
  • Celiac Teen
  • MNBelle blog
  • Gabe351's Blog
  • moosemalibu's Blog
  • Coeliac Disease or Coeliac Sprue or Non Tropical Sprue
  • karalto's Blog
  • deacon11's Blog
  • Nyxie's Blog
  • Swpocket's Blog
  • threeringfilly's Blog
  • Madison Papers: Living Gluten-Free in a Gluten-Full World
  • babinsky's Blog
  • prettycat's Blog
  • Celiac Diagnosis at Age 24 months in 1939
  • Sandy R's Blog
  • mary m's Blog
  • Jkrupp's Blog
  • Oreo1964's Blog
  • keyboard
  • Louisa's Blog
  • Guts & Brains
  • Gluten Free Betty
  • Jesse'sGirl's Blog
  • NewMom's Blog
  • Connie C.'s Blog
  • garden girl's Blog
  • april anne's Blog
  • 4xmom's Blog
  • benalexander60's Blog
  • missmyrtle's Blog
  • Jersey Shore wheat no more's Blog
  • swezzan's Blog
  • aheartsj's Blog
  • MeltheBrit's Blog
  • glutenfreecosmeticcounter
  • Reasons Why Tummy tuck is considered best to remove unwanted belly fat?
  • alfgarrie's Blog
  • SmidginMama's Blog
  • lws' Blog
  • KMBC2014's Blog
  • Musings and Lessons Learned
  • txwildflower65's Blog
  • Uncertain
  • jess4736's Blog
  • deedo's Blog
  • persistent~Tami's Blog
  • Posterboy's Blog
  • jferguson
  • tiffjake's Blog
  • KCG91's Blog
  • Yolo's Herbs & Other Healing Strategies
  • scrockwell's Blog
  • Sandra45's Blog
  • Theresa Marie's Blog
  • Skylark's Blog
  • JessicaB's Blog
  • Anna'sMommy's Blog
  • Skylark's Oops
  • Jehovah witnesses
  • Celiac in Seattle's Blog
  • March On
  • honeybeez's Blog
  • The Liberated Kitchen, redux
  • onceandagain's Blog
  • JoyfulM's Blog
  • keepingmybabysafe's Blog
  • To beer, with love...
  • nana b's Blog
  • kookooto's Blog
  • SunnyJ's Blog
  • Mia'smommy's Blog
  • Amanda's Blog
  • jldurrani's Blog
  • Why choosing Medical bracelets for women online is the true possible?
  • Carriefaith's Blog
  • acook's Blog
  • REAGS' Blog
  • gfreegirl0125's Blog
  • Gluten Free Recipes - Blog
  • avlocken's Blog
  • Thiamine Thiamine Thiamine
  • wilbragirl's Blog
  • Gluten and Maize-Free (gluten-free-MF)
  • Elimination Diet Challenge
  • DJ 14150
  • mnsny's Blog
  • Linda03's Blog
  • GFinDC's Blog
  • Kim UPST NY's Blog
  • cmc's Blog
  • blog comppergastta1986
  • JesikaBeth's Blog
  • Melissa
  • G-Free's Blog
  • miloandotis' Blog
  • Confessions of a Celiac
  • Know the significance of clean engine oil
  • bobhayes1's Blog
  • Robinbird's Blog
  • skurtz's Blog
  • Olivia's Blog
  • Jazzdncr222's Blog
  • Lemonade's Blog
  • k8k's Blog
  • celiaccoach&triathlete's Blog
  • Gluten Free Goodies
  • cherbourgbakes.blogspot.com
  • snow dogs' Blog
  • Rikki Tikki's Blog
  • lthurman1979's Blog
  • Sprue that :)'s Blog
  • twinkletoes' Blog
  • Ranking the best gluten free pizzas
  • Gluten Free Product
  • Wildcat Golfer's Blog
  • Becci's Blog
  • sillyker0nian's Blog
  • txplowgirl's Blog
  • Gluten Free Bread Blog
  • babygoose78's Blog
  • G-freegal12's Blog
  • kelcat's Blog
  • Heavy duty 0verhead crane
  • beckyk's Blog
  • pchick's Blog
  • NOT-IN-2gluten's Blog
  • PeachPie's Blog
  • Johny
  • Breezy32600's Blog
  • Edgymama's Gluten Free Journey
  • Geoff
  • audra's Blog
  • mfrklr's Blog
  • 2 chicks
  • I Need Help With Bread
  • the strong one has returned!
  • sabrina_B_Celiac's Blog
  • Gluten Free Pioneer's Blog
  • Theanine.
  • The Search of Hay
  • Vanessa
  • racecar16's Blog
  • JCH13's Blog
  • b&kmom's Blog
  • Gluten Free Foodies
  • NanaRobin's Blog
  • mdrumr8030's Blog
  • Sharon LaCouture's Blog
  • Zinc, Magnesium, and Selenium
  • sao155's Blog
  • Tabasco's Blog
  • Amanda Smith
  • mmc's Blog
  • xphile1121's Blog
  • golden exch
  • kerrih's Blog
  • jleb's Blog
  • RUGR8FUL's Blog
  • Brynja's Grain Free Kitchen
  • schneides123's Blog
  • Greenville, SC Gluten-Free Blog
  • ramiaha's Blog
  • Kathy P's Blogs
  • rock on!'s Blog
  • Carri Ninja's Blog
  • jerseygirl221's Blog
  • Pkhaselton's Blog
  • Hyperceliac Blog
  • abbiekir's Blog
  • Lasister's Thoughts
  • bashalove's Blog
  • Steph1's Blog
  • Etboces
  • Rantings of Tiffany
  • GlutenWrangler's Blog
  • kalie's Blog
  • Mommy Of A Gluten Free Child
  • ready2go's Blog
  • Maureen
  • Floridian's Blog
  • Bobbie41972's Blog
  • Everyday Victories
  • Intolerance issue? Helpppp!
  • Feisty
  • In the Beginning...
  • Cheri46's Blog
  • Acne after going gluten free
  • sissSTL's Blog
  • Elizabeth19's Blog
  • LindseyR's Blog
  • sue wiesbrook's Blog
  • I'm Hungry's Blog
  • badcasper's Blog
  • M L Graham's Blog
  • Wolicki's Blog
  • katiesalmons' Blog
  • CBC and celiac
  • Kaycee's Blog
  • wheatisbad's Blog
  • beamishmom's Blog
  • Celiac Ninja's Blog
  • scarlett54's Blog
  • GloriaZ's Blog
  • Holly F's Blog
  • Jackie's Blog
  • lbradley's Blog
  • TheSandWitch's Blog
  • Ginger Sturm's Blog
  • The Struggle is Real
  • whataboutmary's Blog
  • JABBER's Blog
  • morningstar38's Blog
  • Musings of a Celiac
  • Celiacchef's Blog
  • healthygirl's Blog
  • allybaby's Blog
  • MGrinter's Blog
  • LookingforAnswers15's Blog
  • Lis
  • Alilbratty's Blog
  • 3sisters' Blog
  • MGrinter's Blog
  • Amanda
  • felise's Blog
  • rochesterlynn's Blog
  • mle_ii's Blog
  • GlamourGetaways' Blog
  • greendog's Blog
  • Tabz's Blog
  • Smiller's Blog
  • my vent
  • newby to celiac?'s Blog
  • siren's Blog
  • myraljo's Blog
  • Relieved and confused
  • carb bingeing
  • scottish's Blog
  • maggiemay832's Blog
  • Cristina Barbara
  • ~~~AnnaBelle~~~'s Blog
  • nikky's Blog
  • Suzy-Q's Blog
  • mfarrell's Blog
  • Kat-Kat's Blog
  • Kelcie's Blog
  • cyoshimit's Blog
  • pasqualeb's Blog
  • My girlfriend has celiacs and she refuses to see a doctor
  • Ki-Ki29's Blog
  • mailmanrol's Blog
  • Sal Gal
  • WildBillCODY's Blog
  • Ann Messenger
  • aprilz's Blog
  • the gluten-free guy
  • gluten-free-wifey's Blog
  • Lynda MEADOWS's Blog
  • mellajane's Blog
  • Jaded's Celiac adventures in a non-celiac world.
  • booboobelly18's Blog
  • Dope show
  • Classic Celiac Blog
  • Keishalei's Blog
  • Bada
  • Sherry's blurbs
  • addict697's Blog
  • MIchael530btr's Blog
  • Shawn C
  • antono's Blog
  • Undiagnosed
  • little_d's Blog
  • Gluten, dairy, pineapple
  • The Fat (Celiac) Lady Sings
  • Periomike
  • Sue Mc's Blog
  • BloatusMaximus' Blog
  • It's just one cookie!
  • Kimmy
  • jacobsmom44's Blog
  • mjhere's Blog
  • tlipasek's Blog
  • You're Prescribing Me WHAT!?!
  • Kimmy
  • nybbles's Blog
  • Karla T.'s Blog
  • Young and dealing with celiacs
  • Celiac.com Podcast Edition
  • LCcrisp's Blog
  • ghfphd's allergy blog
  • https://www.bendglutenfree.com/
  • Costume's and GF Life
  • mjhere69's Blog
  • dedeadge's Blog
  • CeliacChoplin
  • Ravenworks' Blog
  • ahubbard83's Blog
  • celiac<3'sme!'s Blog
  • William Parsons
  • Gluten Free Breeze (formerly Brendygirl) Blog
  • Ivanna44's Blog
  • Daily Life and Compromising
  • Vonnie Mostat
  • Aly'smom's Blog
  • ar8's Blog
  • farid's Blog
  • Sandra Lee's Blog
  • Demertitis hepaformis no Celac
  • Vonnie Mostat, R.N.
  • beetle's Blog
  • Sandra Lee's Blog
  • carlyng4's Blog
  • totalallergyman's Blog
  • Kim
  • Vhips
  • twinsmom's Blog
  • Newbyliz's Blog
  • collgwg's Blog
  • Living in the Gluten Free World
  • lisajs38's Blog
  • Mary07's Blog
  • Treg immune celsl, short chain fatty acids, gut bacteria etc.
  • questions
  • A Blog by Yvonne (Vonnie) Mostat, RN
  • ROBIN
  • covsooze's Blog
  • HeartMagic's Blog
  • electromobileplace's Blog
  • Adventures of a Gluten Free Mom
  • Fiona S
  • bluff wallace's Blog
  • sweetbroadway's Blog
  • happybingf's Blog
  • Carla
  • jaru24's Blog
  • AngelaMH's Blog
  • collgwg's Blog
  • blueangel68's Blog
  • SimplyGF Blog
  • Jim L Christie
  • Debbie65's Blog
  • Alcohol, jaundice, and celiac
  • kmh6leh's Blog
  • Gluten Free Mastery
  • james
  • danandbetty1's Blog
  • Feline's Blog
  • Linda Atkinson
  • Auntie Lur: The Blog of a Young Girl
  • KathyNapoleone's Blog
  • Gluten Free and Specialty Diet Recipes
  • Why are people ignoring Celiac Disease, and not understanding how serious it actually is?
  • miasuziegirl's Blog
  • KikiUSA's Blog
  • Amyy's Blog
  • Pete Dixon
  • abigail's Blog
  • CHA's Blog
  • Eczema or Celiac Mom?'s Blog
  • Thoughts
  • International Conference on Gastroenterology
  • Deedle's Blog
  • krackers' Blog
  • cliniclfortin's Blog
  • Mike Menkes' Blog
  • Juanita's Blog
  • BARB OTTUM
  • holman's Blog
  • It's EVERYWHERE!
  • life's Blog
  • writer ann's Blog
  • Ally7's Blog
  • Gluten Busters: Gluten-Free Product Alerts by Celiac.com
  • K Espinoza
  • klc's Blog
  • Pizza&beer's Blog
  • CDiseaseMom's Blog
  • sidinator's Blog
  • Dr Rodney Ford's Blog
  • How and where is it safe to buy cryptocurrency?
  • lucedith's Blog
  • Random Thoughts
  • Kate
  • twin#1's Blog
  • myadrienne's Blog
  • Nampa-Boise Idaho
  • Ursa Major's Blog
  • bakingbarb's Blog
  • Does Celiac Cause Sensitivites To Rx's?
  • delana6303's Blog
  • psychologygrl25's Blog
  • Alcohol and Celiac Disease
  • How do we get it???
  • cooliactic_BOOM's Blog
  • GREAT GF eating in Toronto
  • Gluten-free Food Recommendations!
  • YAY! READ THIS!!
  • BROW-FREE DIET BLOG
  • carib168's Blog
  • A Healing Kitchen
  • Shawn s
  • AZ Gal's Blog
  • mom1's Blog
  • The Beginning - The Diagnosis
  • PeweeValleyKY's Blog
  • solange's Blog
  • Cate K's Blog
  • Layered Vegetable Baked Pasta (gluten-free Vegetarian Lasagna)
  • Gluten Free Teen by Ava
  • mtdawber's Blog
  • sweeet_pea's Blog
  • DCE's Blog
  • Infertility and Celiac Disease
  • What to do in the Mekong Delta in 1 Day?
  • glutenfreenew's Blog
  • Living in the Garden of Eden
  • toddzgrrl02's Blog
  • redface's Blog
  • Gluten Free High Protein
  • Ari
  • Great Harvest Chattanooga's Blog
  • CeliBelli's Blog
  • Aboluk's Blog
  • redface's Blog
  • Being in Control of Your Gluten-Free Diet on a Cruise Ship
  • jayshunee's Blog
  • lilactorgirl's Blog
  • Yummy or Yucky Gluten-Free Foods
  • Electra's Blog
  • Cocerned husband's Blog
  • lilactorgirl's Blog
  • A Little History - My Celiac Disease Diagnosis
  • How to line my stomach
  • sewfunky's Blog
  • Oscar's Blog
  • Chey's Blog
  • The Fun of Gluten-free Breastfeeding
  • Dawnie's Blog
  • Sneaky gluten free goodness!
  • Chicago cubs shirts- A perfect way of showing love towards the baseball team!
  • Granny Garbonzo's Blog
  • GFzinks09's Blog
  • How do I get the Celiac.com podcast on my mp3 player?
  • quantumsugar's Blog
  • Littlebit's Blog
  • Kimberly's Blog
  • Dayz's Blog
  • Swimming Breadcrumbs and Other Issues
  • Helen Burdass
  • celiacsupportnancy's Blog
  • Life of an Aggie Celiac
  • kyleandjra.jacobson's Blog
  • Hey! I'm Not "Allergic" to Wheat!
  • FoOdFaNaTic's Blog
  • Wendy Cohan, RN's Gluten-Free and Dairy-Free Cooking Classes
  • Lora Derry
  • Dr. Joel Goldman's Blog
  • The Ultimate Irony
  • Lora Derry
  • ACK514's Blog
  • katinagj's Blog
  • What Goes On, Goes In (Gluten in Skin Care Products)
  • What’s new in hydraulic fittings?
  • cannona3's Blog
  • citykatmm's Blog
  • Adventures in Gluten-Free Toddling
  • tahenderson67's Blog
  • The Dinner Party Drama—Two Guidelines to Assure a Pleasant Gluten-Free Experience
  • What’s new in hydraulic fittings?
  • sparkybear's Blog
  • justbikeit77's Blog
  • To "App" or Not to "App": The Use of Gluten Free Product List Computer Applications
  • Onangwatgo
  • Raine's Blog
  • lalla's Blog
  • To die for Cookie Crumb Gluten-Free Pie Crust
  • DeeTee33's Blog
  • http://glutenfreegroove.com/blog/
  • David2055's Blog
  • Gluten-Free at the Fancy Food Show in San Francisco
  • Kup wysokiej jakości paszporty, prawa jazdy, dowody osobiste
  • Janie's Blog
  • Managing Hives & Gluten Allergies
  • Bogaert's Blog
  • Janie's Blog
  • RaeD's Blog
  • Dizzying Disclaimers!
  • Dream Catcher's Blog
  • PinkZebra's Blog
  • Hibachi Food and Hidden Gluten Hazards (How to Celebrate Gluten-Free)
  • jktenner's Blog
  • OhSoTired's Blog
  • PinkZebra's Blog
  • gluten-free Lover's Blog
  • Gluen Free Health Australia
  • Melissamb21's Blog
  • Andy C's Blog
  • halabackgirl9129's Blog
  • Liam Edwards' Blog
  • Celiac Disease in Africa?
  • Suz's Blog
  • Gluten-Free Fast Food
  • mis_chiff's Blog
  • gatakat's Blog
  • macocha's Blog
  • Newly Diagnosed Celiacs Needed for Study in Chicago
  • Poor Baby's Blog
  • the loonie celiac's Blog
  • jenlex's Blog
  • Sex Drive/Testosterone can be Depleted by Certain Foods
  • samantha79's Blog
  • 21 Months into the Gluten-free Diet
  • WashingtonLady's Blog-a-log
  • James S. Reid's Blog
  • Living with a Gluten-Free Husband
  • runner girl's Blog
  • kp3972's Blog
  • ellie_lynn's Blog
  • trayne91's Blog
  • Gluten-free Lipstick!
  • Nonna2's Blog
  • Schar Chocolate Hazelnut Bar (Gluten-Free)
  • pnltbox27's Blog
  • Live2BWell's Blog
  • melissajohnson's Blog
  • nvsmom's Blog
  • Diagnosed with Celiac Disease and Still Sick
  • snowcoveredheart's Blog
  • Gluten Free Nurse
  • Gluten-Free Frustration!
  • Melody A's Blog
  • novelgutfeeling's Blog
  • Trouble Eating Out Gluten-Free...Good or Bad?!
  • dilsmom's Blog
  • theceliachusband's Blog
  • amanda2610's Blog
  • Pancreas and Celiac Disease Link?
  • epiphany's Blog
  • Patty55's Blog
  • The Latest Gluten-Free Food Recalls
  • kenzie's blog
  • CVRupp's Blog
  • Having a Bad Day at the Doctor's Office
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  1. I'm 16. I was diagnosed with Celiac when I was 3 years old, they used a scope. I had been having a lot of pain, and after taking on the gluten free diet, I felt better and grew better. I know it may be risky, but I've been eating gluten for about 2 years now without any Celiac symptoms. I still follow my gluten-free diet most of the time, but when I don't I feel fine, and my stomach does not hurt afterwards. I am, however, often very tired/fatigued, but I don't know if that relates to my diet or not. I would like to see if anyone knows anything about Celiac going away? I've never heard of it before, but I just don't see why I wouldn't be feeling this way if it's not gone. Thanks!
  2. Hi! I recently had a bunch of blood tests done and the only one that was elevated was the TTG-A. My level was 12.6, with negative listed as 0-4 and positive as >15. I asked my doctor about it and she said if I was Celiac my level would have been much higher, and that there wasn’t much research supporting just a gluten sensitivity. That being said, I had been suffering from the following symptoms for YEARS: GERD, indigestion, chronic migraines, extreme fatigue and brain fog, joint pain, and bloating. I’d never considered that gluten was the issue, but I decided to try going gluten-free just to see what happened and I could literally cry by how much better I feel. I feel like I’m alive again. Going forward, is it possible that I am celiac or should I just assume it’s some kind of gluten sensitivity? Do I even need to push for an official diagnosis or should I just continue a strict gluten-free diet and call it good?

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  4. Hi everyone, I have had bowel trouble for about 12 years. It first started with a case of acute diarrhea during jogging. After that the main complaints are bloating and flatulence/burping. It is worse after meals. I had acute diarrhea on a few occasions after eating very buttery/oily food. Twelve years ago my general doctor diagnosed it as IBS (after not founding anything specific). Recently I have revisited the problem in the hope to solve it as it is something I can live with but it still affects your life quite a bit. So I went to a gastro-enterologist. First I had a breath test for lactose which was negative. Then I was checked for celiac disease: As far as I know to diagnose celiac disease you do blood test which give you an indication. This then needs to be confirmed by an endoscopic biopsy. My blood test came back with the following results: Deamidated Gliadin Antibody was positive (6.2 kU/L range 0-3.9) Transglutaminase (IgA) was negative (0.6 kUA/L range < 8.0) I read that the transglutaminase test is more reliable, but we still did the endoscopic biopsy which came out negative. Then a week after telling me I do not have celiac disease because of the biopsy my gastro-enterologist emails me writing; "the lab antibody test for gluten is positive so your condition seems celiac disease". Of course I was surprised as I thought the biopsy should have been the gold standard (and the antibody test was quite uncertain). I asked her, but unfortunately I did not get a reply anymore. So my first question is if I am correct in my conclusion that it is highly unlikely that I have celiac disease? I do have the feeling I react to some products that contain gluten (croissant/pizza/cake/pasta/soy sauce), but others not (e.g. bread).I have tried going gluten free for a week, but there was no impact. I thought that the issue might be fat content as at least croissant/pizza/cake have a higher fat content than bread, so I tried a low fat diet for about a week, but also that did not improve my symptoms. For completeness other deviating blood values are: Bilirubine indirect (1.48 mg/dL range 0-1.10) This is due to a biliary cyste. Cholestrol LDL (185 mg/dL range < 115) Ferritine (378 ug/L range 20-250) Vitamine D (11.2 ng/mL range 30-100) So if my condition is not celiac disease all ideas and advise of what it could be are welcome. Thank you all in advance, Steve
  5. Celiac 08/01/2023 - The Schär company is known for making a wide range of popular gluten-free foods, including gluten-free pastas and breads. However, a test the company is offering, for self-diagnosing celiac disease, has come under scrutiny for potentially promoting misdiagnosis of people with the condition. The test, available online on the company’s website, has raised concerns over its accuracy, and the growing trend of promoting self-diagnosis of celiac and other diseases. Celiac disease is a serious autoimmune condition triggered by gluten consumption. Many cases of celiac disease go undiagnosed, leading to individuals ignoring, or dismissing their symptoms. Early detection is now possible, but self-diagnosis has become a growing trend. Schär Questionnaire About Gluten Consumption & Symptoms To deliver results, the Schär test asks individuals questions about their gluten consumption and symptoms. While not intended to replace professional diagnosis, the test suggests potential gluten intolerance based on common symptoms like fatigue or headaches. Critics argue that the test may overstate celiac disease risk, even for minor symptoms. In a test trial, an individual without any gluten intolerance symptoms took the Schär test. Although it did not detect any potential celiac disease, the individual still sought medical advice due to the questionnaire's prompting. This raises concerns about the test's accuracy and reliability, as well as the growing self-diagnosis trend. Medical professionals emphasize the importance of consulting doctors for proper diagnosis, warning against relying solely on online tests. Celiac disease is complex and requires thorough evaluation by medical professionals to avoid unnecessary dietary restrictions and health risks. Seeking professional medical advice is crucial for an accurate diagnosis and proper management of the condition. Read more at breakinglatest.news
  6. Currently going through the process of eating gluten every day to confirm diagnosis. Have a colonoscopy scheduled on the 27th and trying not to loose hope while eating all this gluten. Breaking out in a rash, brain fog, head aches, joint pain, and of course endless stomach issues and pain. Anyone else on their diagnosis journey? Trying to stay positive and keep going but I really want to just stop eating the big G.
  7. Hello everyone. Brand new to the Celiac scene personally and this is my first post here. I just recently had my tTg-IgA drawn and it came back at 11 U/mL. Standard range 0-3, weak positive 4-10 and 11 or greater positive. A little background: My grandfather was diagnosed late in life (in his 70's) with Dermatitis Herpetiformis via skin biopsy. His physician put him on Dapsone and told him to try to avoid gluten. My grandfather wasn't ever told he had to be strictly gluten free for life. He tried to avoid gluten for a period of time, along with the Dapsone and his DH got better. It sounds like things had calmed down and he was "avoiding" gluten so his doctor took him off Dapsone. Turns out my grandfather didn't realize how important it was for him to be strictly gluten free because he was never educated properly. According to my grandmother, (which is where I got all of this information) he was told he did not have Celiac disease but he was just allergic to wheat. After this, my grandfather decided it was too difficult to avoid gluten in his diet and the doctor agreed to just put him back on Dapsone so he could consume gluten without having all of the DH flare-ups. Eventually this downward spiral led to him having emergency surgical exploration ending up with small-bowel resection due to complications with his small intestines (I'm speculating this is Celiac related but not 100% positive). Throughout the next several years his health continued to rapidly deteriorate to the point he became extremely frail and was using a walker. Fast forward to the day before he passed away. He had fallen and sustained a fractured hip. He had surgical repair that night which eventually led to him being admitted to the ICU due to inability to keep his blood pressure stable. That night, despite all of the ICU IV blood pressure support medications they had him on he passed away. Since it was such a sudden and unexplained death they offered my grandmother an autopsy and she agreed. In the report, according to my grandmother, they put that he had a chronic adrenal gland issue which ended up causing his death. I investigated this some online and I found there was a link between Addison's Disease and Celiac Disease. From what it sounds like to me he went into an Addisonian crisis and led to his death. I started with that story because I am utterly shocked at how little education my grandfather received regarding his diagnosis of DH and to be told he just has a wheat allergy and needs to avoid gluten if possible. I found this website after I tested on the positive scale for tTg-IgA and started reading post after post absorbing as much information as possible. I came to be tested after my younger brother mentioned to me he had been tested for Celiac disease and had a "weak positive" test result on tTg-IgA and was told to go gluten free immediately after that test. He was not given a diagnosis or recommended GI consultation for EGD biopsy. (I have since shared the information I have learned but he already went gluten free and had resolution to most of his symptoms and is not interested in EGD with biopsy or going back on gluten for that matter!). I started to put the pieces together after he told me about his "weak positive" result and started thinking about all of the weird symptoms I had experienced off and on throughout my 33 years of life. As a child I oftentimes would throw up for no reason after eating breakfast or have diarrhea before school. My mom always attributed it to nerves about going to school. She also told me that I threw up at school a lot early on and would be sent to the nurses office but again it was attributed to nerves and apparently I would say things like "I'm afraid my parents won't pick me up after school." I had a lot of childhood anxieties and worries that other children didn't have and my parents thought I was just a sensitive child. Eventually, all of the gastric concerns triggered a pediatric GI consultation. I had an EGD and some form of barium study (as I remember the distinct white poo it produced later). I was just a small child at the time this was happening and now that I'm older I asked my mom if she remembers what they were looking for or what they told her and she can't remember any of the test results. She said they thought it was just stress related. As a child I also developed this strange rash on my hands that presented as small, clear blister-like bumps with a tiny dot in the middle of them and would be on my palms and in between my fingers. The inside of the finger bumps I remember would get kind of raw, itchy and would crust over and the bumps on my palms would just itch a lot. Eventually it just went away and would come and go randomly up until early adulthood. I remember distinctly the last time I had this rash on my hands. I was in California at the beach in my early 20's and I picked up a large bull kelp seaweed and was swinging it around. Later that night I had that rash randomly appear after not having that rash on my hands for years and years. In my early adult life I had 4 different occasions of kidney stones. I know this is a very common thing to happen to people but also found information that said Celiac individuals have a higher incidence of these due to malabsorption issues (correct me if I'm wrong). The biggest symptoms I have been experiencing since 2017, after I just finished up a year long divorce. I started having the most intense anal irritation....I mean this was bad. It was itchy, raw, burning and there was blood whenever I would wipe. This went on for a year until 2018 when I started having other symptoms. I went to my primary doctor and told him I am completely wiped out and feeling fatigued to the point it was very noticeable to me (told me it was stress from going through divorce). I had this "fuzzy" feeling like I was walking around kind of dazed all the time. I also reported having joint pain in my thumb, hip, knee and ankle. They weren't all painful at the same time and the pain would sometimes be there and sometimes be fine. I reported that I had developed a red, bumpy and very itchy rash on my arm that eventually went away and then went to my back. After my back rash went away it moved to my abdomen where it stayed for months and was present at the time of my appointment. I also told him about the severe anal discomfort. He said I had anal fissures and gave me some steroid suppositories. He checked labs for rheumatoid arthritis and lupus which were both negative. He also tested my testosterone which was slightly elevated and checked my leutinizing hormone and follicle stimulating hormone, which were both high. Nothing ever came of these symptoms or tests and I kind of just internalized everything and thought this must just be how I am and I am getting a little bit older now. I continued to have these symptoms off and on until the present time just thinking this is the way I was built. I also always wondered what those bright white areas on four of my teeth were (enamel defects!). My last primary care check up (May 2022) I told the doctor I was feeling really weird and that I felt like the normal everyday things that didn't stress me out before are now stressing me out a lot and getting me down. I told him I was very irritable all of the time for no reason at all. I could have all kinds of great things happening in my life and I was just irritated and moody all of the time (to the point my new wife was noticing a change in character for me and mentioned it). He asked if I wanted to be put on some meds and I told him I didn't want them. I have also been having almost daily minor, annoying headaches almost every single day for several months now. Fast forward to September 2022 and this is the point I put the pieces together and asked my doctor to be screened for Celiac disease. I was given a formal GI referral after my positive test and I am set to go to that appointment today at 3:00 pm. I am seeing a nurse practitioner for the consult due to long wait time to see a doctor. I was assured the NP will be able to order the EGD and will take my history, etc. I'm very apprehensive about the coming EGD because I'm worried they won't be able to see what they need to see or won't biopsy enough sites to give an actual diagnosis. I guess I'm so worried about that because my tTg-IgA was only an 11 U/mL and was just on the cusp of being positive but still considered positive. If my result was much higher I would be less apprehensive I guess. Technically my tTg-IgA is close to 4 times the upper normal level for my lab. I only had my tTg-IgA drawn and didn't know at the time I asked for testing about all of the other things I should have asked for. Should I ask for more celiac tests i.e DGP IGA/IGG, total IGA at my GI consultation today or is the tTg-IgA enough since it was positive? Should I ask to be screened for vitamin deficiencies and what are the most important ones to ask for? Is it rude to ask them how many biopsies they take and is it okay to be pushy and tell them I want 4-6 biopsies?? Thank you for allowing me to tell my story! Sorry it ended up being so long and I would greatly appreciate any feedback, recommendations, etc. if you have time to get through to the end of my novel!! Take care.

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  9. Hi all, a few months back my hubs was going through classic signs of hyperthyroidism and finally got a diagnosis of Graves Disease, which is an autoimmune disease. I bought him a mail order lab test for celiac because I know autoimmune issues like to come in pairs. Here are his results: tTG IgA – 1.7 U/mL – normal tTG IgG – 3.3 U/mL – normal DGP IgA – 28.3 U/mL – Elevated (threshold 14.7) DGP IgG – 6 U/mL – normal From what I've read, the DPG IgA is 100% specific to celiac as it is an autoimmune response to only gliadin? We're getting him set up with a GI, but in the mean time, we're very confused. He also has pretty significant and frequent gas, and what I thought was a cluster of acne on his lower back where his kidney is that has been consistently there for months, though it's a bit cleared up now. I'm thinking this is actually from gluten and isn't actually acne. Now my question is, could this be celiac or could this be due to his Graves? I know about the molecular mimicry with gluten and thyroid hormones so I'm wondering if this elevated result isn't celiac but due to his graves. I know either way we will need to clear the gluten out of the house... Does anyone have any info they can share?
  10. Celiac.com 09/05/2022 - According to studies, most people with celiac disease are exposed to gluten on a regular basis, even those who are trying to be diligent about avoiding gluten. For these people, eating gluten can trigger gastrointestinal symptoms and intestinal damage. Anyone whose ever had that happen can testify to the unpleasant results, including the stomach pain, bloating, diarrhea, and other symptoms. Currently, there aren't too many options for celiacs who are exposed to small amounts of gluten, especially for those exposed on a regular basis. A team of researchers recently set out to assess changes in the ratio of villus height to crypt depth in celiac patients exposed to 2g of gluten per day for 6 weeks, as part of a study on IMGX003 (Latiglutinase). On behalf of theCeliacShield Study Group, the research team included Joseph A. Murray; Jack A. Syage; Tsung-Teh Wu; Chaitan Khosla; and Jennifer A. Sealey-Voyksner. They are variously affiliated with the Mayo Clinic, Gastroenterology and Hepatology in Rochester, MN; the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; ImmunogenX, Inc., Newport Beach, CA; the Boston Biostatistics Research Foundation, Framingham, MA; Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland; and Stanford University, Stanford, CA. The team administered the double-blind, placebo-controlled gluten-challenge as part of a Phase 2 trial to assess the safety and efficacy of a 1,200 mg dose of IMGX003 in celiac patients exposed to 2 g of gluten per day for 6 weeks. The team used ANCOVA to assess progress toward their main endpoint, which was a change in the ratio of villus height to crypt depth (Vh:celiac disease), along with secondary endpoints, which included densities of intraepithelial lymphocytes (IEL) and symptom severity. Tertiary endpoints included serology and gluten-immunogenic peptides (GIP) in urine. Forty-three out of fifty randomized patients completed the challenge. Twenty one patients received IMGX003, while twenty-two received a placebo. The results showed that IMGX003 reduced gluten-induced intestinal mucosal damage and symptom severity in celiac patients on a six week gluten challenge of 2 grams per day. Drugs like IMGX003 could potentially play a role in receding symptoms and gut damage in people with celiac disease who are exposed to low amounts of gluten, especially through accidental exposure. Still, we've seen promising drugs come and go, each falling by the wayside when they failed to deliver in clinical trials. Stay tuned for more on this and related stories. Read more at gastrojournal.org
  11. Celiac.com 08/15/2022 - In a significant finding, a celiac disease registry at University of Alabama reveals significant issues in accurately testing Black people for celiac disease using the TTG antibody test. The new registry of celiac disease patients at the University of Alabama at Birmingham is the work gastroenterologist Dr. Amanda Cartee, MD, and fellow colleagues at UAB. Among the most important findings, the registry reveals that Black people with biopsy confirmed celiac disease are exponentially more likely than non-Hispanic whites to show negative results on the most common diagnostic celiac disease blood test. For people with celiac disease, a positive TTG antibody test is the most common path to an endoscopy and biopsy to confirm or negate celiac disease. For most people with celiac disease, especially non-Hispanic whites, a positive TTG test is highly predictive of celiac disease, hence the routine endoscopy and biopsy to follow-up a positive test. In fact, less than ten percent of non-Hispanic whites with biopsy-proven celiac disease have a "negative" TTG test. However, according to the registry data, high percentages of Black people with celiac disease are testing negative for TTG antibodies, and so being denied a swift and properly diagnosis, simply because they never meet themes common threshold for biopsy. It's the TTG threshold currently used to determine the definition of positive and negative TTG that might just be at the heart of the problem. That's because the numbers are nearly reversed for Black people. While less than ten percent of non-Hispanic whites with celiac disease show negative TTG results, the registry data shows that a whopping eighty percent of Black people with biopsy-proven celiac disease have a "negative" TTG test. The means that these folks were unlikely to have gotten a biopsy as quickly as someone with a positive TTG test. It also means they may have had to suffer longer, and/or self diagnose. And those facts are also borne out by the registry data, which point to longer times to diagnosis and less biopsy-driven diagnoses for Black celiac patients. Black patients were also much less likely to have received genetic testing for celiac-associated genes. There is limited data on celiac disease and Black people, said Dr. Cartee, noting that only a single study with the primary goal of investigating the clinical characteristics of celiac disease and Black people has been done. While the registry revealed differences in TTG test results and BMI, it showed similarities in celiac disease diagnosis for non-Hispanic white and Black patients. These included symptoms as the primary cause for testing, length of time to diagnosis, and a diagnosis that did not include recommended blood tests and a biopsy. Basically, the data show that TTG tests will be negative in the vast majority of Black patients with biopsy-proven celiac disease. That means further study is needed to determine whether the TTG test is useful for Black patients, and more research needs to be done to figure out how to make sure they can get quickly and properly diagnosed. Stat tuned for more on this and related stories regarding celiac disease testing, screening, and diagnosis in Black people, and in other ethnic populations. Read more about the celiac registry data and findings presented by UAB gastroenterologist Dr. Amanda Cartee, MD, at Digestive Disease Week.
  12. Hello, so I’ve been seeing a hematologist for persistent anemia for about a year now and he tested me for celiac disease and it came back positive. However, I received and endoscopy about 4 years ago for and was diagnosed with GERD and IBS, but was negative for sprue. I was given the endoscopy because I had chronic diarrhea and severe acid reflux from 2014-2018 during a very stressful time in my life and my symptoms largely resolved by reducing stress and getting on and SSRI. I have no idea if they did the celiac disease blood panel at that time. I did do one of those mail-in allergy tests and it came back positive for a potential gluten and wheat allergy but I’ve never thought that I felt bad immediately after eating gluten so I never quit because I love carbs. I still have some GERD issues depending on what I eat but am now having issues with constipation these days. I have always had a heavy menstrual cycle that has improved over the years and have always been borderline anemic from it but didn’t start having anemia symptoms until about a year ago. My HGB was always 11-12 and it got down to 9 when I started to feel ill (cold, tired, hair loss, general feeling of unwellness) and sought a hematologist. My iron is very low and and so is my RBC and WBC. I did iron infusions that fixed the problem for about a year and now I’m back to where I was. My other vitamins and minerals and folate are all normal. These were my celiac disease test results: Deamidated Gliadin Abs, IgA: 16 (normal range: 1-19) Deamidated Gliadin Abs, IgG: 56 (normal: 1-19) tTG IgA: 11 (normal: 0-3) tTG IgG: 12 (normal: 0-5) Endomysial Antibody IgA: negative IgA: 278 (normal: 87-352) Is celiac possible in my case? Is there anything else that could be wrong that would produce these results? Should I seek another endoscopy, or is it enough to see if a gluten-free diet puts these numbers back in the normal range? Thanks for reading this whole thing!
  13. Celiac.com 06/06/2022 - Researchers have shown that tissue-transglutaminase antibodies (TGA) can be used to diagnose celiac disease without biopsy, but there's no good data on how accurate it is in real life conditions. A team of researchers recently set out to investigate real-life performance of a Bioplex2200 automated celiac serology analyzer, and to explore the correlation between tissue-transglutaminase antibody levels and intestinal biopsies in children. The research team included Anat Guz-Mark; Michal Kori; Chani Topf-Olivestone; Ronit Weinberger; Sara Morgenstern; Nadya Ziv-Sokolovskaya; and Raanan Shamir. They are variously affiliated with the Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva; the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv; the Pediatric Gastroenterology, Kaplan Medical Center, Rehovot; the Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem; the Immunology Laboratory, Clalit Health Services, Tel Aviv; the Institute of Pathology, Rabin Medical Center, Pitach-Tikva; and the Institute of Pathology, Kaplan Medical Center, Rehovot, Israel. The team conducted a retrospective review in two pediatric gastroenterological centers, between November 1, 2018 and April 1, 2020. They included patients with both tissue-transglutaminase antibody serology testing and duodenal biopsies. They gathered data including patient demographics, medical background, TGA levels, and biopsy results. In all, the team looked at 538 children. They found 256 with positive tissue-transglutaminase antibodies, and 282 with negative tissue-transglutaminase antibodies. Among patients with positive tissue-transglutaminase antibodies, intestinal biopsies confirmed celiac disease in 219, or nearly 86% of cases. The team found positive serology with normal histology in about fifteen percent of the cases. In more than half, they found tissue-transglutaminase antibody ranges of 1 to 3 times upper limit of normal. About twenty percent had tissue-transglutaminase antibody ranges 3 to 5 times upper limit of normal; about twenty percent had tissue-transglutaminase antibody ranges 5 to 10 times upper limit of normal; and just over 4% had tissue-transglutaminase antibody ranges above 10 times upper limit of normal, respectively. Nearly eighty-five percent of patients with positive tissue-transglutaminase antibodies also had positive anti-endomysial antibodies. However, overall diagnostic performance in these patients was inferior. The team found that the Multiplex tissue-transglutaminase antibody assay accurately diagnosed celiac disease in real world conditions. EMA screening did not improve the diagnostic accuracy in patients with positive tissue-transglutaminase antibodies. Meanwhile, false-positives varied depending on tissue-transglutaminase antibody range, but were low in patients with tissue-transglutaminase antibody levels above 10 times upper limit of normal. The ability to use multiplex tissue-transglutaminase antibodies for accurate celiac diagnosis offers clinicians another cheap and easy tool for catching celiac disease early. The easier and cheaper it becomes to diagnose celiac disease, and the earlier it can be caught, the more long term damage can be avoided for celiac sufferers. Read more in the Journal of Pediatric Gastroenterology and Nutrition
  14. Celiac.com 09/14/2018 - Celiac.com was all set to do a story on the latest peer-reviewed data on the Nima gluten testing device, when along comes Gluten-Free Watchdog with another of their famous non-recommendations. Gluten-Free Watchdog says they cannot recommend the Nima gluten test kit because of alleged flaws. But what does the science say? The latest Nima article and Gluten-Free Watchdog’s complaint both focus on the science, so let’s start there. Nima makes two different food sensors: one detects gluten, the other detects peanuts. Each sensor comprises a small, handheld electronic device and a cartridge. To test food, consumers place a pea sized amount into the cartridge, place the cartridge inside the sensor, and run the device. They then receive a smiley face or wheat symbol with "gluten found," depending on whether or not the Nima device detected the allergen. Nima reported their original data in a peer-reviewed scientific journal. Among the conclusions: “Compared with reference R5, Nima antibodies (13F6 and 14G11) had 35- and 6.6-fold higher gliadin affinities, respectively. Nima demonstrated device performance using a comprehensive list of foods, assessing detection sensitivity, reproducibility, and cross-reactivity. Nima presented a 99.0% true positive rate, with a 95% confidence interval of 97.8%–100%.” Gluten Free Watchdog says that: “Based on third party testing data, the Nima Sensor fails to detect gluten at the 20 ppm level over 20 percent of the time. It isn’t until a sample contains a level of gluten at the 40 ppm level, that a gluten found result is received close to 100% of the time.” Gluten Free Watchdog suggests that this is a problem, because: “At a level of gluten in a sample from less than 2 ppm up to a level of gluten between 30 ppm and 40 ppm, the result displayed on the Nima Sensor may be either smiley face or gluten found. If a sample is tested with a Nima Sensor and the result is a smiley face, there is no practical way for a consumer to know if the level of gluten in the sample is less than or more than 20 ppm. If a sample is tested with a Nima Sensor and the result is gluten found, there is no practical way for a consumer to know if the level of gluten in the sample is less than or more than 20 ppm. As a result, the data point received from the Nima Sensor for gluten presents major interpretation problems.” Gluten Free Watchdog charges that Nima uses “NOT the scientifically validated Ridascreen Gliadin R5 ELISA Mendez Method from R-Biopharm used by Gluten Free Watchdog.” The fact is that R5 Elisa remains the industry standard for most testing applications. Gluten Free Watchdog closes its warning with a word from their independent expert: According to Adrian Rogers, Senior Research Scientist at Romer Labs, “It could be argued that the device is not fit for purpose as the company states that there is a clear differentiation between safe and unsafe products based on a 20 ppm level which the validation data does not corroborate.” It’s worth noting that for all his accomplishments, Rogers is neither a doctor, nor a PhD. Rogers' LinkdIn page lists his education as: Bsc (Hons), Microbiology, University of Wales, Aberystwyth. A Bachelor of Science degree may not necessarily make an expert in this subject, yet he is presented as one. Rogers also seems to have a potential conflict of interest that was omitted in Thompson’s press release. Directly from Rogers’ LinkdIn site: “Romer Labs®, Inc. developed an immunochromatographic lateral flow assay for the qualitative detection of gluten in raw ingredients, processed foods, finished food products, and environmental surfaces, using the G12 antibody developed by Belén Morón. The G12 antibody targets a 33-mer peptide which is resistant to enzymatic digestion and heat denaturation, as well as being the fragment of the gliadin protein to which celiac disease sufferers react, making it a reliable analytical marker.” The company Rogers works for, Romer Labs, makes its own gluten testing kits. It seems a bit disingenuous for Gluten Free Watchdog to use a spokesperson from a potentially competing company to try to counteract a peer-reviewed scientific publication for a device which is made by a potential competitor. Nima’s Scientific Advisory Board includes some of the most highly respected celiac disease researchers and scientists in the world. They include: Peter HR Green, MD Phyllis and Ivan Seidenberg Professor of Medicine. Director, Celiac Disease Center at Columbia University; Jody Puglisi, PhD Stanford University Professor of Structural Biology; Lucille Beseler, MS, RDN, LDN, CDE, FAND Family Nutrition Center of South Florida; Benjamin Lebwohl, MD, MS Director of Clinical Research Celiac Disease Center at Columbia University; John Garber, MD Gastroenterology, Mass General; and Thanai Pongdee, MD Consultant, Division of Allergic Diseases, Mayo Clinic. Nima says that Gluten Free Watchdog’s view of their recently published validation is incomplete and misleading. Nima wrote: “All the studies show Nima is highly sensitive across a range of both low and high levels of gluten." "The Nima third party data accurately reported gluten found at 20 ppm and above between 93.3% for food as prepared (a food item that is spiked with an intended quantity of gluten) and 97.2% for food as quantified by an ELISA lab kit (used to determine the exact ppm of gluten in the food)." "The Nima peer reviewed study published in the Food Chemistry Journal reported gluten found at 20 ppm and above at 96.9% accuracy." The statement that: “'Nima will fail to detect gluten at 20 ppm 20% of the time' is almost entirely driven by 1 specific food out of 13 tested. That sample, when quantified, was actually below 20 ppm." "In real life, people get glutened at many different ppm levels, not just 20 ppm. Nima has been shown to detect gluten at levels below, at and above 20 ppm across a variety of foods in a number of studies.” Reading the peer reviewed data provided by Nima, and reading Gluten Free Watchdog’s complaints, it becomes clear that Gluten Free Watchdog’s complaints sound serious and authoritative, but ring a bit hollow. Consider the Following Analogy Imagine a gluten-sniffing dog that performed as well as Nima in scientific trials; same performance, same exact data. You can give this dog a sniff, or a small bite of food, and he can signal you if the food’s got gluten in it with 97% accuracy at 20ppm or below. Nearly 100% accuracy at 40ppm or above (as stated by Gluten Free Watchdog). People would think that the dog was not only cute and fluffy, but wonderfully helpful and everyone would love it, and everyone with celiac disease would want one. And it would be a great big gushing warm and fuzzy feel-good story. Pretty much no one would be arguing that the dog was potentially dangerous, or somehow unfit for people with celiac disease. Such dogs would also be far more expensive to own and maintain than the Nima device. Apparently such dogs can cost upwards of $16,000, not including the cost of food, vet bills, etc. So, what’s the accuracy rate of a gluten-sniffing dog, anyway? From Mercola.com: Willow, a German shorthaired pointer, is another gluten-sniffing dog, in this case living in Michigan. Her owner, Dawn Scheu, says she can detect gluten with 95 percent to 98 percent accuracy. She worked with a trainer (the same one who trained Zeus) to teach her own dog to detect gluten, with excellent results. Gluten-sniffing dogs may detect gluten in amounts as small as .0025 parts per million with 95 percent to 98 percent accuracy. So, will Gluten Free Watchdog be warning against gluten-sniffing dogs anytime soon? Somehow, because Nima is a mechanical device made by a company, it's not so warm and fuzzy, not so feel-good. Maybe Nima needs to shape their device like a cute little doggy, or a Pez candy dispenser? But the data remains, as does the fact, whatever its drawbacks, anything that detects gluten like Nima does, as well as it does, is potentially very helpful for celiac disease in numerous situations. And it is extremely unlikely to do them any harm. Nima seems very much committed to transparency, scientific excellence, and continual product improvement. These are noble goals and generally a win for people with celiac disease. Think of it, just ten years ago, a portable gluten-sensor with the kind of accuracy Nima is reliably achieving would have been the stuff of fantasy. Yet here it is. More accurate than any gluten-sniffing dog, and for a couple hundred bucks. People with celiac disease are living in a very different world than just a few years ago. Nima did not have to publish its data, but it chose to do so, and in a reputable, peer-reviewed scientific journal. Nima conducted its research using solid scientific standards, and reported those results publicly. They explained their methodology and results, they acknowledged product limitations and expressed a commitment to improvement. How is this remotely controversial? The celiac disease community is fortunate to have companies committed to investing time and money into products and devices that help to improve the lives of people with celiac disease. We feel strongly that the perfect should not be the enemy of the good. Devices like the Nima gluten sensor can be helpful for numerous people with celiac disease. Disclosure: Nima is a paid advertiser on Celiac.com. Celiac.com's advertisers do not influence our editorial content. Read Nima’s full report on test data at: Food Chemistry.com Read Gluten Free Watchdog’s Statement on the Nima device at: Glutenfreewatchdog.org Read Nima’s Reply to Gluten Free Watchdog at: Nimasensor.com
  15. Celiac.com 01/08/2022 - Celiac disease is a chronic inflammatory disease of the gut occurring in genetically susceptible individuals after ingestion of gluten. It is characterized by a flattened mucosa, villous atrophy and crypt hyperplasia in the small intestine and by the classic malabsorption syndrome (diarrhea, steatorrhea, and weight-loss) or by minor apparently unrelated symptoms such as iron-deficiency anaemia, osteopenic bone disease, amenorrhea and infertility(1). The diagnostic algorithm of this disease demand a screening approach based on anti-endomysium (EmA) and anti-tissue transglutaminase (anti-tTG) and, in case of antibodies-positivity, patients should undergo intestinal biopsy to confirm the presence of small bowel lesions according to celiac disease. Unfortunately, this approach is rarely effective in clinical practice, especially in patients with mild to moderate histological lesions. In fact several recent studies have shown that 5-10% of patients affected by mild to moderate lesions of the small bowel typically seen in celiac disease actually lack EmA and anti-tTG antibodies(2-5). In light of these scientific results, should all patients who are suspected to have, or who are at risk for celiac disease—including first degree relatives of celiacs, those with Down’s syndrome or autoimmune thyroid disease, patients whose stories indicate celiac disease, etc.—undergo intestinal biopsy? This does not seem like a very reliable approach—perhaps other more non-invasive tests should be done in conjunction with serological testing to help determine which patients should undergo a biopsy. The sorbitol H2 -breath test (H2 -BT) could be exactly what is needed. Sorbitol is a hexahydroxy alcohol that is present in many fruits such as peaches6 . It is used as a sugar substitute in dietetic foods and as a drug vehicle. At low doses (5 grams/day) sorbitol is completely absorbed by the small bowel, and low dose ingestion does not typically produce any symptoms. However, we know that celiac disease patients often experience sugar malabsorption (as lactose malabsorption)(7), which prompted us to hypothesize that the same may be true for sorbitol. In general terms, sugar malabsorption could be primary— congenital enzymatic/ carrier deficiency, or acquired—developing after intestinal damage caused by acute gastroenteritis, medications, Crohn’s disease, celiac disease, etc.(8) In the normal individual, gut bacteria are primarily located in the colon and in the distal small intestine. When sugar malabsorption is present, unabsorbed sugars in excess are available in the distal small bowel and colon for bacterial fermentation, with air excretion of H2 and CH4 9 . This mechanism occurs for all sugars— lactose, fructose, glucose, sorbitol—and H2 lactose, fructose and sorbitol breath tests are commonly used to detect specific sugar malabsorption issues. Sorbitol H2-BT Methods This is a simple, non invasive, repeatable, and cheap test. To minimize basal hydrogen excretion, subjects are asked to have a carbohydrate-restricted dinner on the day before the test (for example, a meal of rice and meat) and are studied after an overnight fasting for at least 12 hours. On the testing days, patients do a mouthwash with 20 ml of chlorhexidine 0.05%; smoking and physical exercise are not allowed for 30 minutes before and during the test. End expiratory samples are collected before the patients drink the test solution— 5g of sorbitol in 150/200 ml of tap water—and every 30 minutes for 4 hours using a two-bag system. The two-bag system is a device consisting of a mouthpiece, a T-valve and two collapsible bags, for collection of dead space and alveolar air. From this system, the breath sample is aspirated into a 20 ml plastic syringe. Samples are generally evaluated for H2 using a model DP Quintron Gas Cromatograph (Quintron Instrument Company, Milwakee, WI). It is also possible to measure the hydrogen concentration in each collected sample by a portable breath-hydrogen analyzer (for example, EC60 Gastrolyzer Breath Hydrogen Monitor, Bedfont Scientific Ltd, Upchurch – Kent, England [U.K.]). An increase in H2 concentration of at least 20 ppm over fasting baseline is considered positive for sorbitol malabsorption. The cut-off for calculating the validity of the test is shifted every 30 minutes, and a Response Operating Characteristics (ROC) curve is plotted on the basis of the obtained results. Results are expressed as parts per million (ppm). Sorbitol H2-BT and Celiac Disease The first study assessing the effectiveness of sorbitol in detecting intestinal damage in celiac disease was performed by Corazza, et al. in 1988. They showed for the first time that low dose concentrations of sorbitol (5 grams at 2%) are malabsorbed in almost all celiac disease patients(10), and these results were confirmed in a more recent study(11). These provocative results led to the idea that it could be used as a screening tool in celiac disease, in addition to serological tests. However, these results have not been completely considered by investigators, and using sorbitol H2 -BT to screen for celiac disease was not investigated further for another four years. In the 2001 we published a paper about the low-prevalence of anti-gliadin and anti-endomysium antibodies in a sub-clinical/silent form of celiac disease. We found that 5-20% of celiac disease patients affected by this form of the disease lack these antibodies according to histological damage4 , and we found the same results using anti-tTG12. Based on this research it was apparent that there was a risk of not properly diagnosing a very high percentage of celiac disease patients if their screening is based solely on serological tests. At this point we tried to use the sorbitol H2 -BT as screening tool to obtain more information on patients’ intestinal absorption, and to help select patients who should undergo intestinal biopsy. Sorbitol H2-BT in Detecting the Sub-clinical/Silent Form of Celiac Disease Sub-clinical celiac disease is defined by the presence of a gluten sensitive enteropathy with extra-intestinal symptoms (iron-deficiency anemia, alopecia, recurrent abortion, Breath Test, continued “there was a risk of not properly diagnosing a very high percentage of celiac disease patients if their screening is based solely on serological tests” etc.) but without gastrointestinal symptoms, whereas silent celiac disease is defined by the presence of a gluten-sensitive enteropathy not accompanied by any symptoms, but identified during the course of screening of high-risk groups such as first-degree relatives of celiac patients, patients with insulin-dependent diabetes, Down’s syndrome, IgA deficiency and thyroid disorders. In detecting silent celiac disease sorbitol H2 -BT seems to be better than serological tests. We found that EmA were positive in 77/96 (80.80%) and sorbitol H2 -BT was positive in 94/96 (97.91%) of patients with sub-clinical celiac disease, whereas EmA were positive in 17/27 (62.96%) and sorbitol H2 -BT was positive in 26/ 27 (96.29%) of patients with silent celiac disease (p<0.001 in both forms of celiac disease). The best cut-off value in ppm and minutes in both forms of celiac disease are higher and shorter in the severe form rather than in the mild form of intestinal damage respectively (p<0.001 in both forms)13. Therefore sorbitol excretion seems to be closely correlated with the severity of histological lesions. Sorbitol H2-BT as Screening Test in Relatives of Celiac Disease Patients The prevalence of celiac disease among first-degree relatives has been reported to be about 10- 20%, and approximately 50% of the newly diagnosed cases are asymptomatic(14,15). It is known that lymphoma and cancer deaths(16,17) occur more frequently in first-degree relatives of celiac disease patients, and it is also known that gluten withdrawal has a protective role in the complications associated with the disease(18). However, up to 50% of celiac disease relatives show mild histological damage without evident mucosal atrophy(19-21). Since several recent studies showed that serological tests are ineffective in detecting celiac disease in patients with mild histological damage, there is a concrete risk that a significant proportion of celiacs among relatives may be missed. Since a routine intestinal biopsy in all family members is, however, unfeasible—asymptomatic individuals would rarely accept such an approach—it is very important to identify an optimal non-invasive method of screening first-degree relatives. In this regard sorbitol H2 -BT screening seems to be better than serological tests. In my experience, sorbitol H2 -BT is extremely effective at detecting histological damage in relatives of those with celiac disease. We found that AGA, EmA and anti-tTG showed strong positivity only when there was severe intestinal damage (Marsh IIIb-c lesions—but overall positivity was 36.73%, 38.78%, and 44.89% for AGA, EmA and anti-tTG respectively), whereas sorbitol H2 -BT showed a strong positivity in patients with only mild histological damage (Marsh I - IIIa—overall positivity was 83.67%). A significant proportion of celiac disease patients will be missed if relatives of those with celiac disease are screened only via serology(22). Sorbitol H2-BT in Assessing Histological Recovery after a Gluten-free Diet Currently the only effective therapeutic approach to celiac disease is the gluten-free diet, and the result of a proper gluten-free diet is clinical and histological improvement. In particular, the gluten-free diet plays a key role in preventing nutritional deficiency, especially of micronutrients, and in reducing the risk of the development of intestinal malignancies. There is great demand for highly sensitive, non-invasive tests that can be done to determine histological recovery in patients after the start of a gluten-free diet—with the ultimate goal of reducing or eliminating the need of follow-up endoscopies and biopsies. If we consider EMA an indicator of small bowel damage, it would be expected to persist until histological recovery occurs. However, several recent studies failed to show a positive relationship between EMA and histological improvement after a gluten-free diet(23-26). Our study confirmed these experiences, since microscopic damage persists at histological examination during the follow-up despite EMA negativity. It is difficult to explain the poor predictor value of EMA in assessing histological recovery. EMA positivity seems to be related not only to the length of intestinal involvement but also to the grade of histologic damage(4) . Thus, when histological damage improves we can note a false EMA negativity, since histological lesions improve more slowly than EMA seroconversion. Moreover, EMA are a marker of the immunological activity related to the gluten sensitivity, it is therefore hypothesized that after a period of gluten restriction the immunological process can be quite inactive and thus EMA will subside. Similarly, anti-tTG do not seem effective to assess histological recovery in the follow-up of celiac patients after they have started a gluten-free diet due to its poor correlation with histological damage. Anti-tTG is generated in genetically predisposed individuals by complexes formed between anti-tTG and gluten(27). So, it is hypothesize that anti-tTG should disappear soon after gluten withdrawal, and these findings have been frequently recognized in our clinical practice, for example we sometimes see a quick subsiding of anti-tTG values soon after patients begin a gluten-free diet—in some cases within few weeks. In my experience, sorbitol H2-BT seems to be very effective even in assessing histological recovery after gluten-free diet. We found a strict correlation between cut-off values (in ppm and minutes) of H2 excretion and the patients’ histological lesions. In particular, maximal cut-off values (in ppm and in minutes) correlate statistically with a more severe degree of intestinal damage—patients with more severe histological lesions had higher cut-off value H2 levels and earlier peaks (in minutes). Likewise, we found that progressive histological recovery correlated significantly with decrease of maximal cut-off values (in ppm) and with the later appearance of the peak (in minutes). This is a very important finding, since it permits us to observe and to monitor the progressive improvement of the histological damage of small bowel after a gluten-free diet—without any small bowel biopsy(28, 29). Sorbitol H2 -BT in Borderline Entheropathy A clinical problem arises when patients present with symptoms suggestive of gluten sensitivity (diarrhea, weight loss, unresponsive iron-deficiency anemia, etc.) but small intestinal biopsies reveal only minor abnormalities, particularly lymphocytosis with or without crypt hyperplasia (Marsh I-II lesions). It is hypothesized that some of these patients have borderline celiac disease. A gluten challenge may be a good choice in these patients, as it may provoke a significant worsening of the mucosal lesions, which could lead to a correct diagnosis. This approach, however, may not be necessary if we have a sensitive non-invasive method to detect such mild intestinal lesions. Serological tests are insufficient in this area. We recently found that AGA, EmA and anti-tTG were positive in 0-20% of patients showing Marsh I-II lesions, whereas sorbitol H2 -BT was positive in 18- 41% of such cases(30). Clearly this data shows that it makes sense to use Sorbitol H2 -BT to detect cases of borderline entheropathy. Factors Affecting Sorbitol H2-BT in Clinical Practice Unfortunately, several factors may affect the results of sorbitol H2 -BT. First of all, sorbitol H2 -BT shows high sensitivity but low specificity. Several small bowel disorders, including Crohn’s disease, are associated with excessive rates of H2 breath excretion and then with sorbitol H2 -BT positivity(31). Moreover, the breath tests will be positive in the setting of not only small bowel mucosal injury, but also in cases of rapid intestinal transit and small bowel bacterial overgrowth(32). Finally, despite its low cost, the breath test is quite cumbersome, since it requires an overnight fast followed by at least 4 hours of the patient’s time for testing. Conclusion Sorbitol H2 -BT is a simple, feasible, repeatable, cheap, non-invasive test that can accurately assess intestinal absorption. Unfortunately low specificity may affect the results and may make it difficult for us to distinguish the different causes of malabsorption using only the sorbitol H2 -BT results. On the other hand, sorbitol H2 -BT may be very helpful and seems to be very promising in the following areas: Identifying patients suspected of having celiac disease with mild intestinal damage, who are serologically negative for celiac disease; Screening relatives of patients with celiac disease; Monitoring dietary compliance to the gluten-free diet Although intestinal biopsies will remain the “gold standard” for assessing the state of small bowel, sorbitol H2 -BT is a very interesting and non-invasive test that has the potential to reveal just how large the current “black hole” in celiac disease diagnosis is. At the very least it can help diagnose patients whose complaints cause us to suspect celiac disease but who have negative blood tests, and it is an excellent method to monitor the recovery of patients who are on a gluten-free diet. It is a key part of my medical practice in the treatment of celiac disease. References: Martucci S, Biagi F, Di Sabatino A, Corazza GR. Coeliac disease. Dig Liver Dis 2002; 34(suppl. 2): S150-3. Rostami K, Kerckhaert J, Tiemessen R, von Blomberg ME, Meijer JWR, Mulder CJJ. Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac disease: disappointing in clinical practice. Am J Gastroenterol 1999;94: 888-94. Dickey W, Hughes DF, McMillan SA. Reliance on serum endomysial antibody testing underestimates the true prevalence of coeliac disease by one fifth. Scand J Gastroenterol 2000;35: 181-3. Tursi A, Brandimarte G, Giorgetti GM, Gigliobianco G, Lombardi D, Gasbarrini G. Low prevalence of antigliadin (AGA) and anti-endomysium (EMA) antibodies in subclinical/silent celiac disease. Am J Gastroenterol 2001;96: 1507-10. Abrams JA, Diamone B, Rotterdam H, Green PHR. Seronegative celiac disease: increased prevalence with lesser degrees of villous atrophy. Dig Dis Sci 2004;49: 546-50. Washüttl J, Reiderer P, Baucher E. A qualitative and quantitativestudy of sugar-alcohols in several foods. J Food Sci 1973;38: 1262-3. Ojetti V, Nucera G, Migneco A et al. High prevalence of celiac disease in patients with lactose intolerance. Digestion 2005;71: 106-10. wagerty DL Jr, Walling AD, Klein RM. Lactose intolerance. Am Fam Physician 2002;65: 1845-50. Strocchi A, Ellis C, Levitt MD. Reproducibility of measurement of trace gas concentrations in expired air. Gastroenterology 1991;101: 175-9. Corazza GR, Strocchi A, Rossi R, Sirola D, Gasbarrini G. Sorbitol malabsorption in normal volunteers and in patients with coeliac disease. Gut 1988;29: 44-8. Pelli MA, Capodicasa E, De Angelis V, Morelli A, Bassotti G. Sorbitol H2-breath test in celiac disease. Importance of early positivity. Gastroenterol Int 1998;11: 65-8. Tursi A, Brandimarte G, Giorgetti G. Prevalence of anti-tissue transglutaminase antibodies in different degrees of intestinal damage in celiac disease. J Clin Gastroenterol 2003; 36(3): 219-221. Tursi A, Brandimarte G, Giorgetti GM. Sorbitol H2- breath test versus anti-endomysium antibodies for the diagnosis of subclinical/ silent coeliac disease. Scand J Gastroenterol 2001;36: 1170-2. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunologic approach to the spectrum of gluten sensitivity (celiac sprue). Gastroenterology 1992;102: 330-54. Auricchio S, Mazzacca G, Tosi R, Visakorpi J, Maki M, Polanco I. Coeliac disease as familial condition: identification of asymptomatic patients within family groups. Gastroenterol Int 1988;1: 25-31. Barry RE, Morris JS, Kenwright S, Read AE. Coeliac disease and malignancy. The possible importance of familial involvement. Scand J Gastroenterol 1971;6: 205-207. Stokes PL, Prior P, Sorahan TM, McWalter RJ, Waterhouse JA, Cooke WT. Malignancy in relatives of patients with coeliac disease. Br J Prev Soc Med 1976;30: 27-21. Holmes GKT, Prior P, Lane MR, Pope D, Allan RN. Malignancy in coeliac disease – effect of gluted free diet. Gut 1989;30: 333-8. Corazza GR, Valentini RA, Frisoni M ETAL. Gliadin immune reactivity is associated with overt and latent enteropathy in relatives of celiac patients. Gastroenterology 1992; 103: 1517-22. Maki M, Holm K, Lipsaen V, Hallstrom O, Viander M, Collin P et al. Serological markers and HLA genes among healthy first-degree relatives of patients with coeliac disease. Lancet 1991;338: 1350-3. Vazquez H, Cabanne A, Sugai E, Fiorini A, Pedreira S, Maurino E et al. Serological markers identify latent coeliac disease among first-degree relatives. Eur J Gastroenterol Hepatol 1996;8: 15-21. A. Tursi, G. Brandimarte, G.M. Giorgetti, C.D. Inchingolo. Effectiveness of sorbitol H2 breath test in detecting histological damage among relatives of coeliacs. Scand J Gastroenterol 2003;38: 727-31. Bardella MT, Trovato C, Cesana BM, Pagliari C, Gebbia C, Peracchi M. Serological markers of celiac disease: is it time to change? Digest Liver Dis 2001;33: 426-31. Valentini RA, Andreani ML, Corazza GR, Gasbarrini G. IgA endomysium antibody. A valuable tool in the screening of coeliac disease but not its follow-up. Ital J Gastroenterol 1994;26: 279-82. Sategna-Guidetti C, Grosso SB, Bruno M, Grosso S. Is human umbilical cord the most suitable substrate for the detection of endomysium antibodies in the screening and follow-up of coeliac disease? Eur J Gastroenterol Hepatol 1997;9: 657-60. Dickey W, Hughes DF, McMillan SA. Disappearance of endomysial antibodies in treated celiac disease does not indicate histological recovery. Am J Gastroenterol 2001;95: 712-4. Dieterich W, Ehnis T, Bauer M et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997;3: 797-801. Tursi A, Brandimarte G, Giorgetti GM. Sorbitol H2- breath test versus antiendomysium (EMA) antibodies to assess histological recovery after gluten-free diet in coeliac disease. Dig Liver Dis 2002;34: 846-50. Tursi A, Brandimarte G, Giorgetti GM. Lack of effectiveness of anti-transglutaminase antibodies in assessing histological recovery after gluten-free diet in celiac disease. J Clin Gastroenterol 2003;37: 381-5. Tursi A, Brandimarte G. The symptomatic and histological response to a gluten-free diet in patients with borderline enteropathy. J Clin Gastroenterol 2003;36: 13-7. Tursi A, Giorgetti GM, Brandimarte G, Elisei W. High prevalence of celiac disease among patients affected by Crohn’s disease. Inflamm Bowel Dis 2005;11: 662-6. Nucera G, Gabrielli M, Lupascu A et al. Abnormal breath test to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth. Aliment Pharmacol Ther 2005;21: 1391-5.
  16. Hi everyone, I have my biopsy in a month and my gastroentorologist said I need to eat a lot of gluten before. He suggested that I eat like 2-4 slices of bread every day or similar to make sure I'm eating enough gluten. But, unfortunately, I've recently had a relapse with my restrictive eating disorder (I am receiving professional support). The typical foods that are high in gluten (bread, pasta, baked goods, etc.) are also very high in calories so it's going to be very difficult for me to eat these foods at the moment. I was wondering if anybody knew of any types of foods or food brands that contain gluten but are low in calories so I can prepare for the biopsy properly? Thank-you. ❤️
  17. Celiac.com 08/17/2021 - Diagnosis for celiac disease is based on intestinal symptoms together with the evaluation of genetic (HLA-DQ2+ and/or DQ8+), serologic (anti-endomysium and antitransglutaminase autoantibodies), and histologic markers. Because celiac disease is highly under-diagnosed, and tests are expensive and invasive, a team of researchers recently set out to analyze the expression of inflammatory genes in the intestine and saliva of celiac patients and controls to find salivary biomarkers that resemble the status of the intestinal epithelium and that could be used for diagnosis. Though some efforts have been made to use saliva for celiac screening, no one has used gene expression analyses of celiac-related inflammatory cytokines. The researchers sought to leverage the saliva collection to set up HLA genotyping in this fluid, thereby increasing the diagnostic power of the gene signature. The research team included M. Sebastian-dela Cruz; A. Olazagoitia-Garmendia; A. Huerta Madrigal; K. Garcia-Etxebarria; L. M. Mendoza; N. Fernandez-Jimenez; Z. Garcia Casales; E. de la Calle Navarro; A. E. Calvo; M. Legarda; C. Tutau; I. Irastorza; L. Bujanda; J. R. Bilbao; and A. Castellanos-Rubio. To select potential biomarkers, the researchers quantified the expression of 92 inflammatory genes in intestinal and saliva samples from three celiac patients and three control subjects. Fourteen of the genes tested were expressed in all samples from saliva and small intestine. The team selected the eight inflammatory genes with the highest and most reproducible expression levels for subsequent analysis in intestinal and saliva samples from another 18 celiac patients and 21 non-celiac subjects. All genes were expressed in the intestine, though a few genes could not be detected. To determine if inflammatory gene expression in saliva mirrors the state of celiac intestinal epithelia, the team compared gene expression between celiac and non-celiac patients in both tissues. Their results revealed that genes CXCL1 and IL1B were up-regulated in celiac biopsy specimens, while CXCL1 and IL1B showed increased expression in patient saliva samples. The research team's analysis of intestine and saliva showed statistically remarkable correlation between the levels of these genes in both tissues, which indicates that the celiac-related changes of intestinal gene expression can be detected in saliva. The researchers call for further study to determine if these or other changes in saliva gene expression are detectable in the gut or mouth of people with other conditions. Read more in Cellular and Molecular Gastroenterology and Hepatology The researchers in this study are variously affiliated with the Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU, Leioa, Spain; the Department of Pediatrics, University of the Basque Country, UPV/EHU, Leioa, Spain; the Biocruces Bizkaia Health Research Institute, Barakaldo, Spain; the Enfermedades Digestivas, Hospital de Galdakao-Usansolo, Galdakao, Spain; Biodonostia, Gastrointestinal Genetics Group, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, San Sebastian, Spain; Department of Gastroenterology, Biodonostia Health Research Institute, Universidad del País Vasco, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, San Sebastian, Spain; Hospital de Txagorritxu, Gasteiz, Spain; the CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Madrid, Spain; and the Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
  18. Celiac.com 07/06/2021 - People who have celiac disease have to eat a gluten-free diet, otherwise, they risk physical discomfort, intestinal damage, and potentially increased risks for numerous related conditions, and even deadly types of cancer. Most tests that screen for celiac disease work by detecting the antibodies that indicate the presence of celiac disease. One of the big drawbacks about celiac disease blood screening is that people usually have to eat gluten for 6-12 weeks in order for the tests to be accurate, and sometimes wait a couple of weeks more before the final results are known. This is often followed by a biopsy where you need to continue eating gluten for even longer periods. That can mean weeks or months of feeling very bad, followed by weeks of uncertainty for many people who are trying to figure out if they have celiac disease. But what if we could screen for celiac disease in a quick, reliable and accurate way? That's been an elusive goal for researchers for many years. That may be set to change, with the recent discovery by Anna Nguyen, a biochemistry student from at Metropolitan State University of Denver. Ngyuen has discovered a faster, easier way to detect celiac disease. The discovery arose as part of Nguyen's 2016 undergraduate research project. “I was really passionate about learning nutrition and diet, but eventually I got to the point where I was more interested in the science behind nutrition,” Nguyen said. “And it led me down this biochemistry route and wanting to get my Ph.D., which requires you to do undergrad research.” The method developed by Nguyen, and her fellow undergraduate researchers, would be faster and easier, and require a simple finger prick. “What we wanted to do was just do make a quick blood test that, maybe just after a day of eating gluten, you could be able to go to your doctor, get a pinprick blood test, and it would just tell you immediately.” The only problem is that Ngyuen's test uses an electrochemical biosensor. Even though electrochemical biosensor technology is currently not laboratory approved, the team is hopeful that it can be developed into a fast, convenient, and reliable test that will be used widely by both clinicians and patients. Keep an eye out over the next few years for more on this and other improvements in celiac blood testing. Read more at: 9news.com
  19. Celiac.com 02/22/2021 - The skin has long been thought to be the body's largest organ. Recently, however, researchers discovered that the largest organ might actually be the interstitium, which lies just beneath the skin's outermost layers. It is that interstitial tissue that is the focus of a new biometric skin patch that may eventually diagnose numerous ailments faster and easier, and more cleanly than traditional blood tests. However, this is no easy task, as the interstitial tissue won't give up its secrets easily. Even though it's close to the skin, and close to blood, getting enough useful fluid from the interstitial tissue to get accurate test data is a bit like squeezing blood from a stone. Getting even a thousandth of a tablespoon, an amount still hundreds of times smaller than a standard blood draw, remains a challenge. A new development might offer a way around that challenge. In a recent paper, researchers at Washington University in St. Louis report using disposable micro-needle patches to capture ISF biomarkers, and to measure them up to about 800 times greater sensitivity than comparable biomarker tests. The thin rectangular patches contain hundreds of plastic micro-needles, each less than a millimeter long. To use them, simply press the patch against your finger, then dip the patch into a liquid solution of nanoparticles, which will sense and reveal presence of the certain known proteins. Because blood based testing can present logistical and financial challenges for poor and/or rural populations, such a test represents a logistical, scientific and financial breakthrough. "Currently, the new skin patches work on just a few biomarkers, but by significantly improving the sensitivity of immunoassays,” says Srikanth Singamaneni, a materials scientist who led the study, researchers may be able to help to meet the "need for bio-diagnostics in low- and middle-income countries—and even in rural parts of the United States.” The test can detect cytokine IL-6, and research has shown that detecting cytokines may be the best way to diagnose gluten sensitivity. A cheap, portable, reliable test that could spot celiac disease, gluten sensitivity and other health conditions, could be a major benefit to large numbers of people who remain undiagnosed, and for whom traditional blood tests are often out of reach. The team's data appears in Nature Biomedical Engineering. Read more on this in an excellent article by Wired.com
  20. Celiac.com 07/18/2019 - Autoimmune conditions cause the body to attack its own healthy cells. There are nearly one-hundred known autoimmune conditions, including lupus, celiac disease, and rheumatoid arthritis. Diagnosing autoimmune conditions can sometimes be difficult, so any progress toward faster, cheaper, or more reliable testing methods could play a significant role in improving diagnosis and reducing time to treatment. Approval by the FDA is key to making such tests available commercially. A New York startup company, Aesku.NY, has received FDA approval for tests to detect two of those autoimmune diseases, with tests for other diseases expected to follow. The approved tests for celiac disease, and the connective tissue disorder, lupus, would still require patients who screen positive to receive further testing for a specific diagnosis. However, the tests are designed to be cost effective, and efficient, potentially increasing the availability of a reliable screening method for diseases that are best caught and treated early. "In many autoimmune diseases, if you don't have a good test, it takes many years to pinpoint a diagnosis," says company founder Dr. Vijay Kumar. "Again, coming back to celiac disease, it used to be 3-5 years before a diagnosis is made," he added, "[t]hink about how many physicians, clinicians, laboratories, the patient might have gone through." Aesku.NY tests are produced domestically, in Buffalo New York. Stay tuned for more news on developments in celiac disease diagnostics, and related topics. Listen to WBFO's Mike Desmond
  21. Celiac.com 10/17/2017 - Are primary care physicians under-testing for celiac disease in patients with iron deficiency anemia? A new survey of primary care doctors indicates that they are. It's fairly common for people with celiac disease to develop iron deficiency anemia (IDA), but researchers don't know much about the frequency with which primary care physicians test for celiac disease in patients with IDA. A team of researchers recently set out to describe how primary care doctors approach testing for celiac disease in asymptomatic patients with IDA. The research team included Marisa Spencer, Adrienne Lenhart, Jason Baker, Joseph Dickens, Arlene Weissman, Andrew J. Read, Seema Saini, and Sameer D. Saini. They are variously affiliated with the Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America; the Department of Internal Medicine, Henry Ford Health System, in Detroit, Michigan, United States of America; the Department of Statistics, University of Michigan, Ann Arbor, Michigan, United States of America; the Research Center at the American College of Physicians, in Philadelphia, Pennsylvania, United States of America; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America, Ambulatory Care, Veterans Affairs Medical Center, Ann Arbor, Michigan, United States of America. For their study, the team began by electronically distributing a survey to primary care doctors who are members of the American College of Physicians. The survey asked whether doctors would test for celiac disease, either by serologic testing, referral for esophagogastroduodenoscopy [EGD], or referral to GI) in hypothetical patients with new IDA, including: (1) a young Caucasian man, (2) a premenopausal Caucasian woman, (3) an elderly Caucasian man, and (4) a young African American man. The team chose the scenarios to assess differences in testing for celiac disease based on age, gender, and race. They used multivariable logistic regression to identify independent predictors of testing. Testing for celiac disease varied significantly according to patient characteristics, with young Caucasian men being the most frequently tested (61% of respondents reporting they would perform serologic testing in this subgroup (p Interestingly 80% of doctors surveyed said they would definitely or probably start a patient with positive serologies for celiac disease on a gluten-free diet prior to confirmatory upper endoscopy, which is contrary to guideline recommendations. This survey indicates that primary care doctors are under-testing for celiac disease in patients with IDA, regardless of age, gender, race, or post-menopausal status. The majority of primary care doctors surveyed do not strictly adhere to established guidelines regarding a confirmatory duodenal biopsy in a patient with positive serology for celiac disease. Clearly, even with all of the advances in celiac disease awareness and with more refined protocols, primary care doctors have some work to do when it comes to testing IDA patients for celiac disease, and even more work to do in following proper referral guidelines before putting patients on a gluten-free diet. Source: PLOSONE
  22. Celiac.com 06/11/2020 - Who should get screened for celiac disease? Traditionally, doctors test for celiac disease, based on the following factors: Signs and symptoms of malabsorption, including chronic diarrhea with weight loss, steatorrhea, abdominal pain after eating, and bloating, or: Laboratory evidence of malabsorption, particularly in people who have a first-degree family member with a confirmed celiac disease diagnosis. This includes associated nutritional deficiencies, or: A personal history of an autoimmune disease, or an IgA deficiency, or: Biopsy-proven DH, iron-deficiency anemia refractory to oral supplementation, or hypertransaminasemia with no other origins. So who, exactly, should be screened for celiac disease? Celiac Disease Screening Recommendations per Organization: The North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) Recommends celiac disease screening in asymptomatic children who have conditions associated with celiac disease, including type 1 diabetes mellitus, autoimmune thyroiditis, Down syndrome, Turner syndrome, Williams syndrome, selective IgA deficiency, and first-degree relatives of celiac patients. It recommends testing asymptomatic children who are at risk beginning around age 3 years, provided they have had an adequate gluten-containing diet for at least 1 year before testing. It recommends that asymptomatic persons with negative serology who are at risk be considered for repeat testing. The American College of Gastroenterology Recommends that asymptomatic persons with a first-degree relative who has a confirmed diagnosis of celiac disease be considered for testing. Patients with type 1 diabetes mellitus should be tested for celiac disease if there are any digestive symptoms, signs, or laboratory evidence suggestive of celiac disease. The U.K. National Institute for Health and Care Excellence Recommends offering serologic testing for celiac disease to persons with a first-degree relative with celiac disease or persons with type 1 diabetes mellitus or autoimmune thyroid disease upon diagnosis. They also recommend considering serologic celiac testing for persons with metabolic bone disorder (reduced bone mineral density or osteomalacia), unexplained neurologic symptoms (particularly peripheral neuropathy or ataxia), unexplained sub-fertility or recurrent miscarriage, persistently elevated liver enzymes with unknown cause, dental enamel defects, Down syndrome, or Turner syndrome. Based on more recent study data, many doctors are beginning to do celiac screening in patients with: Anemia A 2014 study showed that celiac disease is common in people with unexplained autism. The study team recommends celiac screening for anyone with unexplained iron-deficient anemia. Autism People with autism have celiac disease at rates almost 20 times higher than in those without autism, reported lead investigator Daniel Karb, MD, a second-year resident at University Hospitals Case Medical Center in Cleveland. As such, many doctors now recommend celiac screening for people with autism. Autoimmune Disorders Researchers urge primary care doctors to adopt a practice of celiac screening for all people with elevated risk factors, including people with a family history of celiac disease, people with Addison’s disease Down Syndrome type 1 diabetes, thyroiditis, Turner syndrome, and type 1 diabetes. The team also called for screening of patients with short stature, iron deficiency anemia, and high transaminase levels. First-degree Relatives of Celiacs A Mayo Clinic team found celiac disease in 160 of 360 first-degree relatives of celiac patients, while 62% of those relatives found to have celiac were women. Most doctors now recommend testing first degree relatives of celiac disease patients. IgA Deficiency The North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition recommends testing for celiac disease in asymptomatic children who have conditions associated with celiac disease, including selective IgA deficiency. Unexplained Neuropathy Patients with unexplained neuropathy, or small fiber neuropathy should be screened for celiac disease and gluten-sensitivity, according to researchers. Consider Celiac Screening for Top Physical Complaints People with any one or more of the Ten Most Common Complaints of Celiac Patients, might want to consider the possibility of celiac disease, look for any other celiac-related symptoms, and consult a doctor if they suspect celiac disease. The ten most common physical complaints of people who have celiac disease are: Osteopenia/Osteoporosis; Anemia; Cryptogenic hypertransaminasemia; Diarrhea; Bloating; Aphthous stomatitis; Alternating bowel habit; Constipation; Gastroesophageal reflux disease and Recurrent miscarriages. Most People with Celiac Disease Show No Symptoms Remember that most people who are diagnosed with celiac disease show no symptoms at the time of their diagnosis. What's Involved in Celiac Disease Screening? Find out what's involved in screening and testing for celiac disease.
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