I've posted a few times in other threads about this, but thought I'd start a new topic that puts my question right out there Am I correct in thinking that if it was non-celiac gluten intolerance or gluten sensitivity, a person would not have elevated antibodies? Does anybody have any research or articles that discuss other known causes of high DGP igG besides celiac?
I have had two celiac panels done in the last month that contained the following tests:
DGP igG and igA
ttg igA and ttg igG
EMA
*I am not igA deficieint
Both times my DGP igG has been flagged as high, and everything else has been negative. my GI doctor said he would look into if there were other things that would cause an elevated DGP igG level, but at that point, he wasn't aware of any.
"What is the percentage of false positives for DGP-IgA?
DGP-IgA is less specific than DGP-IgG and should not be relied upon as a follow-up test for those with celiac disease."
In follow-up blood testing, why would tTG be negative and DGP be positive?
If the slightly positive test is the DGP-IgA, you can disregard this value, as it can be misleading. If the DGP-IgG is positive it probably means you’re ingesting small amounts of gluten, possibly from cross-contamination, which are raising antibodies but not enough to trigger a tTG or a mucosal response. Basically, in either case you shouldn’t worry too much.
How much exposure to gluten does it take for DGP to become elevated and how long before it will return to normal?
There is no general rule that applies to all, but we learn from each patient. That said, typically DGP are more sensitive to gluten than tTG, so they become elevated before tTG and disappear sooner than tTG once on a gluten-free diet.
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thanks for the links I had actually read through those articles and FAQs during my previous research and was hoping someone would have a clear cut link answer like chicago does for other causes of raised ttg iga antibodies except for DGP igG antibodies http://www.curecelia...ent-in-my-diet
If I was NCGI or gluten sensitive, I should not have raised DGP igG antibodies...yes/no?
There are a few things that can temporarily raise tTG, but I have yet to find things other than celiac disease that falsely raised DGP - and I have done extensive pubmed searches along with asking each member that comes here with this question to ask their doctor for a reason besides Celiac Disease.
To date no one's doc has had an answer to that question - yet many of those doctors (most) suggest the wait and see if the patient becomes possitive on another antibody test as time passes. Horrid plan - again in my opinion - all that waiting is damaging the small intestine further which leads to problems in many of the body's systems.
There are a few things that can temporarily raise tTG, but I have yet to find things other than celiac disease that falsely raised DGP - and I have done extensive pubmed searches along with asking each member that comes here with this question to ask their doctor for a reason besides Celiac Disease.
To date no one's doc has had an answer to that question - yet many of those doctors (most) suggest the wait and see if the patient becomes possitive on another antibody test as time passes. Horrid plan - again in my opinion - all that waiting is damaging the small intestine further which leads to problems in many of the body's systems.
I would have to agree. It would seem the more logical step would to be to eliminate the potential cause, gluten, and see if it fixed the problem.....you know, that phrase about "do no harm"?
I had a DGP IgG of 11.5 on a >10 scale with salmonella and retest a few months later returned to negative. Mind you my initial result was so close to the positive/negative line that it could have just been laboratory error as well but perhaps the infection raised it temporarily? My IgA form was negative and I am IgA sufficient.
I had a DGP IgG of 11.5 on a >10 scale with salmonella and retest a few months later returned to negative. Mind you my initial result was so close to the positive/negative line that it could have just been laboratory error as well but perhaps the infection raised it temporarily? My IgA form was negative and I am IgA sufficient.
thanks for the suggestion! I checked the symptoms of salmonella, but it doesn't seem to match-up with me. My DGP igG tests were both strongly positive. Greater than 30 was strongly positive for my lab, and I had a 43 and it dropped slightly to a 41 on the second testing. My main symptoms are continuous bloating and frequent C for the last two years. I've also tested low for vitamin d, k and potassium.
Correct....in my opinion.
There are a few things that can temporarily raise tTG, but I have yet to find things other than celiac disease that falsely raised DGP - and I have done extensive pubmed searches along with asking each member that comes here with this question to ask their doctor for a reason besides Celiac Disease.
To date no one's doc has had an answer to that question - yet many of those doctors (most) suggest the wait and see if the patient becomes possitive on another antibody test as time passes. Horrid plan - again in my opinion - all that waiting is damaging the small intestine further which leads to problems in many of the body's systems.
Lisa, thanks for the info! I don't know if I'll get a chance to talk to my doctor before my EGD this Wednesday, but if yes, I'll try to remember to ask if he's been able to find a reason yet besides celiac for the elevated DGP igG. If not, I'll ask him again during my April follow-up.
so before my EGD today, I asked my GI if he was able to find another cause of high DGP igG besides celiac, and he said he was unable to locate another reason for the elevated number. It was great to hear him say that there is a lot of ongoing research with celiac and food intolerance in general. He said that for a long time doctors have told patients that the symptoms were all in their heads, but now the medical world is trending towards that these symptoms are not in patients' heads but instead the problems lie in their GI tract. we could have all told him that
He also talked about gluten intolerance, but I did ask him that if I did have gluten intolerance vs celiac, that shouldn't be raising my DGP igG antibodies, and he said that was correct.
My initial results from my EGD were a diagnosis of GERD and a hiatal hernia. He took 8 biopsies and said there was slight inflammation in one area, so I will know the biopsy results in a few weeks!
Am I correct in thinking that if it was non-celiac gluten intolerance or gluten sensitivity, a person would not have elevated antibodies? Does anybody have any research or articles that discuss other known causes of high DGP igG besides celiac? 
