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Gi Doc Noticed My Low Total Serum Iga....
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so he said even though I tested negative, and with a negative biopsy, to go ahead and avoid gluten, corn, soy and potatoes!  I was going to bring up the low IgA but he brought it up first!  I am having trouble swallowing food and pills again, so because of the low Iga, he wants to do an immune electrophoresis, which I guess will check IgM, IgG and IgE to see if there's some kind of reaction going on. Has anyone had this done because of low IgA? what were your results?

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To my understanding, if you have a low total IGA, they move to IgG for the testing.

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Hi , yes I know, but he didn't say they would do another celiac panel using IgG and also basically said I am negative case closed on that. He just said test for immune electrophoresis.hm.

 
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Interesting.  I just looked up immunoelectrophoresis. 

 

http://medical-dictionary.thefreedictionary.com/immunoelectrophoresis

Normal results
Reference ranges vary from laboratory to laboratory and depend upon the method used. For adults, normal values are usually found within the following ranges (1 mg = approximately 0.000035 oz. and 1 dL = approximately 0.33 oz.):

    IgM: 60-290 mg/dL
    IgG: 700-1,800 mg/dL
    IgA: 70-440 mg/dL

 

I wonder what he intends to do with this information??

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I have no idea. My test is tomorrow and I"m sure it will probably take 7-10 days to get the results.  I will post back when I get it.

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I don't want you to be frightened but since you asked the immunoelectrophoresis is used to look for a number of conditions some of which are more benign than others.  Your doc is being more proactive than most, and looking to make sure there is not something serious that might escape notice.  Here is a run-down from Healthline:

 

Why Is the Test Ordered?

 

To Confirm a Diagnosis

 

The immunoelectrophoresis-serum (IEP-serum) test is ordered to help
diagnose an underlying health condition. Your doctor may order the test
if abnormal results have been detected through other laboratory tests.
The IEP-serum test may be ordered if you show symptoms of:

 

  • a chronic infection

  • an autoimmune disease

  • a protein-losing disease, such as enteropathy (a disease of the intestines) or inflammatory bowel disease

  • Waldenström’s macroglobulinemia

 

The test can be used to rule out conditions such as leukemia and multiple myeloma. Symptoms of these disorders include:

 

  • weakness and fatigue

  • weight loss

  • broken bones

  • recurrent infections

  • weakness in the legs

  • nausea/vomiting

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I've had this test. It shows up a lot of things and helps you rule out some things, I have eosinophil inflammation caused by gluten damage and a leaky gut, this test showed the reason why when it came back with very high IgE levels. My IgA and IgG are within range I believe but my IgM was a little high (not much) my IgE was 4100!. I will post back my results when my wife comes home as my paperwork is in the car. 4100 was something like 40x over the normal limit and helped both with understanding the eosinophil level, the gut pain and pointed us in the right direction to diagnose Kimuras disease which I also have :S!. Without this test I would still be very much in the dark about what to do about it. The test takes a week to come back but if there's a major anomaly like with mine they will do some more work on it to double check and it might take two weeks.

 

If they find something weird in the Ig levels they might then send you to an immunologist for more in depth testing of the Interleukin levels or something like that. If the IgE levels are high you will go to an Allergist first maybe... I'd say skip him and find someone that does both if it comes to that (but it probably wont)

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Thanks! foam, did you have to fast for this test?  I was told to fast but can't seem to find anything on the 'net saying so.

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Um I don't think I had to fast, but I had lots of blood tests drawn that day and I had to fast for some so I was fasting for them all :).

 

Here's my results anyway, seems I got confused in my earlier post it was the IgA that was a little high but the IgE is the crazy one for me.

 

In the brackets are healthy reference ranges. Bold are those results out of range.

 

Serum Immunoglobulins

IgG: 14.7 g/L (5.2-16.0)

IgA: 3.62 g/L (.85-3.50)

IgM: 2.09 g/L (.32-3.00)

 

IgE is a separate test here but was ordered with this one

Serum Immunoglobulin E : 4105 kU/L (0-200)

 

IgE is the one that gets pumped when you have a leaky gut and also for my Kimura's disease, which causes what is debatable :) but I think I'm being sensible in leaning towards the gut. On another not related note I've managed to hold my Vitamin D over 100 all summer without supplements  I'll have to get back on them soon, just something I'm proud of :P because it was a big effort to get it up to 100.

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    • I figured I would update those who were wondering.  I have gotten the appt. so far moved up to August 30. I am waiting to have gene testing done via swab for all 3 of my kiddos tomorrow. My daughters celiac antibodies came up negative but her IgA is low which the ped said could cause false negative antibodies for celiac so she will need to see a GI dr. also. The pediatrician is going to call the GI to try to get them in sooner. I am keeping them all on a gluten diet until the GI dr. decides what to do. I am on the cancellation list already for my son, however I am not going to be persistent with my phone calls to them until I have the results of the gene test. I really want that result in my hand before going to the GI dr if I can. Maybe if he is positive, along with his bloodwork and my history they can forgo the endoscopy. But he will eat gluten till then.  My husband and I have been very honest and upfront with him as to what is going on and the possibility of the endoscopy and what that entails and although scared in general he seems ok after assuring him that since I have it he has me to help him every step of the way.  Going through his current diet with him I realized that he is truly on such a low gluten diet that I am actually surprised his bloodwork shows antibodies at all!  So I told him to make a list of allllll the gluten he could possibly think of eating and he needs to pound it until the GI visit or endoscopy. Funny thing is everything he keeps thinking of to want to eat...is already gluten free!  The other night we were at a friends and he asked if he could be done with his hotdog. I made him finish just the bread 😂 Thanks for your help and advise and I will keep y'all posted on both kids!  My oldest is a ok as far as all his antibodies. Just actually had a follow up for other immune issues and all his levels are now normal!
    • I like your plan Cara, I may have to include it in my sons.    Poor little guy is still very very sick. I think he is resisting and cheating, despite having the support of two other siblings and a 100% gluten-free home. 
    • Despite it being a nightmare, I did wait for my kids to get biopsies. At one point I had one severely ill child gluten-free and two more waiting having to eat it. It was worth the wait though and I think long term a biopsy may be worthwhile, especially for school. I have already had issues with schools and camps so having a firm diagnosis has been helpful. 
    • Knowing that the reaction to gluten in celiacs is an uncalled for immune system reaction, I was thinking of how a cure would be possible. Maybe a medicine that somehow turns off the immune system. The only thing that i've heard do that... HIV.  obviously that's way worse than celiac. Just some food for thought.
    • Well, you can probably get an apple or something.  You might be able to get someone to boil you some eggs.  But be careful of things like nuts that should be naturally gluten free.  They have almost always been soaked in a flavor solution that usually containes caramel coloring, "soy" (wheat) sauce and other aditives.  If I am really hungry and must eat in a Chinese restaurant, I order plain white rice and steamed vegetables.  But even so, you must monitor it carefully.  The rice sometimes has other substances added to give it a better texture, and very often the vegetables have in fact had "just a little bit" of soy sauce added.  To be fair, celiac disease is hardly ever found in East Asians, so understandably people are not tuned it to it.  Also, culturally, with the exception of fruits, it is generally thought that the flavor of foods needs to be enhanced, so it is had to find anything natural even in the "western" gorceries. Even in the western restaurants, be careful.  Fish and meat and often vegetables are usually pre-marinated. I will not even attempt to address the issue of cross-comtamination, since that is a whole higher order of things. I do know what I am talking about; I have celiac and have worked here for nearly 7 years.  
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