Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Where Your Contribution Counts!
    eNewsletter
    Support Us!

New To Celiac. Test Results--Celiac Or Gluten Sensitivity?


decemberhill

Recommended Posts

decemberhill Newbie

My 5 year old daughter had lab work done because of her weight. She has not gained anything in over 2 years and is sitting steady at 32 pounds, she will be 6 in July. Her lab work came back yesterday with the result of possible Celiac Disease and her PCM has referred her to a Gastroenterologist...just waiting for the referral to go through. I am completely clueless about all of this, nothing like this crossed my mind...I actually figured it would be a thyroid issue. I went through her symptoms the last few years and this is what I have...

 

Decreased appetite

Diarrhea (not constant but at least once or twice a week)

Easily bruises

Very poor weight gain

Fatigue

Mouth Sores

 

Since I am so new to any of this, I have tried really hard to look through all the lab results here and try to decipher my daughters. I have spent the whole afternoon reading this site. 

 

Here are the labs

 

IgA 143 (Normal) Limits 33-185 mg/dL

Endomysial Screen (Negative)

tTG Ab, IgA 2.0 Range <20 Negative, 20-25 Equivocal, >25 Positive

 

Gliadin Peptide Ab, IgG 22.6 (Abnormal) Range <20 Negative, 20-25 Equivocal, >25 Positive

Gliadin Peptide Ab, IgA 4.1 (Normal) Range <20 Negative, 20-25 Equivocal, >25 Positive

 

tTG Ab, IgG 17.4 (Normal) Range <20 Negative, 20-25 Equivocal, >25 Positive

 

Thanks in advance to anyone who can offer me some input! 

 

 

Link to comment
Share on other sites

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



mushroom Proficient

Welcome to the board, decemberhill,  :) and I am sorry it looks like your post has been missed and overlooked :(   Let me attempt to rectify.

 

Your daughter's blood test results show that she makes normal quantity of IgA antibodies, and therefore the IgA testing should be valid for her.

 

The most specific test, endomysial antibodies (EMA) is not positive and her tTG Ab IgA is also negative, as is her Gliadin Peptide Ab IgA (DGP IgA).  However, her Gliadin Peptide Ab IgG (also known as DGP IgG)  is positive.  IgA and IgG are both autoimmune antibodies.  The IgA is usually used and considered to be the celiac antibody; but if an individual does not make normal total quantities of IgA they use the IgG tests.

 

There has recently been some discussion on the board about the meaning of IgG positives on the DGP, and what it means if the person being tested is a normal IgA producer.  Nobody so far has been able to state that it means anything other than celiac disease.  This is probably the reason for the GI referral, so that he can do an endoscopy with biopsy to check for celiac damage in the small intestine.  Do not let him say it is not necessary.  Insist on having it done, and that he take at least 6 samples, because the DGP is the most sensitive of the tests and tends to catch early celiac disease, before there is too much damage.  And if there is not too much damage the naked eye is unable to see it and we have to rely on the biopsy samples and the microscope :)

Link to comment
Share on other sites
powerofpositivethinking Community Regular

Decemberhill,

 

The only test I came back positive on was the DGP igG.  I am currently waiting for my biopsy results to come back in a few weeks.  I see that your daughter bruises easily, as I do too.  I thought it was something to do with my iron, but it turned out my iron and ferritin levels were fine.  I'm deficient in Vitamin K, which also causes bruising  :wacko:

 

here are two links to threads I have started:

https://www.celiac.com/forums/topic/99439-need-help-with-tests-results-please/

https://www.celiac.com/forums/topic/100245-other-known-causes-of-high-dgp-igg-besides-celiac/

 

hope these give you some other ideas!

Link to comment
Share on other sites
decemberhill Newbie

Thank you so much for your responses. The other diagnosis they are throwing around is Cystic Fibrosis and we go in to talk about that on Thursday. I would much rather it be a Gluten issue. 

 

From my reading and I hope I am correct...the test she was positive with, the DGP IgG shows that there is tissue damage relating to gluten? Also, on two of the tests testing IgA are low...does that mean anything or is that a good thing? Our referral for GI has been approved, although the Dr she was referred to does not treat children so I had to find her a pediatric GI which I think works much better. The Ped Dr has a special interest in Celiac. 

 

PowerOfPositive...please let me know how your biopsies turn out. Looking at so many labs and trying to decipher, I remember seeing your post about only being positive with the DGP IgG. I have started a food diary for my daughter as well as documenting her poo everyday. Is there anything else I should document or note? The GI said that new patient appts are already booked into June...so I think it's going to be a long time before we can get in...unless we get lucky and get a cancellation! 

 

Again, thank y'all so much. This board has been really helpful!

Link to comment
Share on other sites
mushroom Proficient

Normally, the IgA testing is considered to be best for those who are IgA sufficient.  The DGP is a newer test than the tTG, is more specific for celiac disease, and tends to pick it up earlier than the tTG.    The low IgA results just show that those tests were negative.  So long as she makes sufficient overall IgA, the low scores on IgA testing have no special significance.  You do not have to be positive on all tests to be celiac - why having the entire panel is recommended.

Link to comment
Share on other sites
decemberhill Newbie

Thanks, Mushroom! That makes sense. 

Link to comment
Share on other sites
powerofpositivethinking Community Regular

Thank you so much for your responses. The other diagnosis they are throwing around is Cystic Fibrosis and we go in to talk about that on Thursday. I would much rather it be a Gluten issue. 

 

From my reading and I hope I am correct...the test she was positive with, the DGP IgG shows that there is tissue damage relating to gluten? Also, on two of the tests testing IgA are low...does that mean anything or is that a good thing? Our referral for GI has been approved, although the Dr she was referred to does not treat children so I had to find her a pediatric GI which I think works much better. The Ped Dr has a special interest in Celiac. 

 

PowerOfPositive...please let me know how your biopsies turn out. Looking at so many labs and trying to decipher, I remember seeing your post about only being positive with the DGP IgG. I have started a food diary for my daughter as well as documenting her poo everyday. Is there anything else I should document or note? The GI said that new patient appts are already booked into June...so I think it's going to be a long time before we can get in...unless we get lucky and get a cancellation! 

 

Again, thank y'all so much. This board has been really helpful!

 

 

 

 

I will let you know how my biopsies turn out!  I definitely think keeping a food and poop diary would be great.  I even talked about my bowel movements to the GI with the bristol stool chart in mind.  Check it out if you haven't!  I would also suggest keeping track of water.  During my first GI appointment when I said I was frequently bloated and constipated, he asked the obligatory questions of how much fiber and water are in my diet.  I was able to tell him I usually drink between 60-80 oz. of pure water a day in addition to the fruits and veggies I eat.  Documenting any rashes of anything with pictures would also be very helpful.  According to Dr. Rodney Ford, DGP is suggestive of gluten gut damage Open Original Shared Link  I am iga sufficient, but my IGA scores were both low.  I'm a 27 y/o female, but since your daughter is 5, Dr. Ford says that ttG is not as reliable in children.  

 

When the GI was going over reasons for Vitamin K deficiency, he mentioned cystic fibrosis, but people tend to be diagnosed as children so that was not applicable to me.  Are you able to get vitamin and mineral testing for children?  can anyone please help me out with this question?  Based on what you said, I would definitely make sure she is tested for Vitamin K.  If you can get your GP to do this, that will give you more information for your GI appointment.   I asked my OB/GYN if she would be willing to order vitamin/mineral testing for me, which thankfully she did without a problem.  When I had my second appointment with the GI, I said my OB/GYN sent you results from some more testing.  He said that Vitamin D deficiency was common, but I peaked his interest when I said I was Vitamin K deficient.  He said he normally doesn't see patients with that deficiency, and according to University of Maryland, a GI doctor is the type of doctor I would expect to see this deficiency since a lot causes seem to be malabsorption issues.  Open Original Shared Link  I haven't used antibiotics since last April, I don't have a blocked bile duct, no serious burns, so it seems that it's due to some kind of malabsorption for me.  I will be taking 5 mg of Vitamin K a day and 2000 iu of Vitamin D as directed by my OB/GYN and GI.  

 

I would suggest calling the GI to see if you can get in on a cancellation.  Repeated phone calls are not a bad thing  :)   I hope she starts feeling better soon!!

Link to comment
Share on other sites

Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



  • 4 weeks later...
RobinB28 Newbie

I will let you know how my biopsies turn out!  I definitely think keeping a food and poop diary would be great.  I even talked about my bowel movements to the GI with the bristol stool chart in mind.  Check it out if you haven't!  I would also suggest keeping track of water.  During my first GI appointment when I said I was frequently bloated and constipated, he asked the obligatory questions of how much fiber and water are in my diet.  I was able to tell him I usually drink between 60-80 oz. of pure water a day in addition to the fruits and veggies I eat.  Documenting any rashes of anything with pictures would also be very helpful.  According to Dr. Rodney Ford, DGP is suggestive of gluten gut damage Open Original Shared Link  I am iga sufficient, but my IGA scores were both low.  I'm a 27 y/o female, but since your daughter is 5, Dr. Ford says that ttG is not as reliable in children.  

 

When the GI was going over reasons for Vitamin K deficiency, he mentioned cystic fibrosis, but people tend to be diagnosed as children so that was not applicable to me.  Are you able to get vitamin and mineral testing for children?  can anyone please help me out with this question?  Based on what you said, I would definitely make sure she is tested for Vitamin K.  If you can get your GP to do this, that will give you more information for your GI appointment.   I asked my OB/GYN if she would be willing to order vitamin/mineral testing for me, which thankfully she did without a problem.  When I had my second appointment with the GI, I said my OB/GYN sent you results from some more testing.  He said that Vitamin D deficiency was common, but I peaked his interest when I said I was Vitamin K deficient.  He said he normally doesn't see patients with that deficiency, and according to University of Maryland, a GI doctor is the type of doctor I would expect to see this deficiency since a lot causes seem to be malabsorption issues.  Open Original Shared Link  I haven't used antibiotics since last April, I don't have a blocked bile duct, no serious burns, so it seems that it's due to some kind of malabsorption for me.  I will be taking 5 mg of Vitamin K a day and 2000 iu of Vitamin D as directed by my OB/GYN and GI.  

 

I would suggest calling the GI to see if you can get in on a cancellation.  Repeated phone calls are not a bad thing  :)   I hope she starts feeling better soon!!

It's entirely possible to be diagnosed with Cystic Fibrosis and Celiacs. I myself have both, I was diagnosed with CF at 6 months old but struggled until I was 26 with a lot of numerous health issues. I think having CF made my docs write off the possibility of Celiacs also being an issue but the vitamin deficiencies are the same and a lot of the symptoms are the same. Many people have been diagnosed as adults with CF, the oldest person ever diagnosed was in her sixties and her only symptoms up until then were chronic sinus infections and a few bouts of pnuemonia. Get tested for both.

Link to comment
Share on other sites
1desperateladysaved Proficient

An osteopathic functional medicine doctor I had my 9 year old son too was offering nutrient absorption tests for him.  Yes, children may get them.  Some chiropractors can order them.  In the end my son didn't have them.  I had nutrient tests and they were very helpful for me.

 

Diana

Link to comment
Share on other sites
Aprilelayne Newbie

While we are still in the testing mode for my 2yr old...just wanted to confirm that nutrient testing is also done at the young age.

She's had a baseline and a followup already since she was 18months old.

 

(granted no closer to a dx, but we are watching nutrient levels)

Link to comment
Share on other sites
kareng Grand Master

While we are still in the testing mode for my 2yr old...just wanted to confirm that nutrient testing is also done at the young age.

She's had a baseline and a followup already since she was 18months old.

 

(granted no closer to a dx, but we are watching nutrient levels)

Not sure what exactly you mean? A doctor can test blood to see if the iron, vit D, B12, etc is at a good level or not. I would be careful about some of these " tests" by "doctors" that are not MDs. Many have no real science behind them and are designed to extract your money as insurance won't cover them.

Link to comment
Share on other sites
Aprilelayne Newbie

Sorry, my post was in response to the question here:

When the GI was going over reasons for Vitamin K deficiency, he mentioned cystic fibrosis, but people tend to be diagnosed as children so that was not applicable to me.  Are you able to get vitamin and mineral testing for children?  can anyone please help me out with this question?  Based on what you said, I would definitely make sure she is tested for Vitamin K.  If you can get your GP to do this, that will give you more information for your GI appointment. 

Yes, any MD is able to the testing, as we are seeing only MDs for my daughter's dx quest.

 

I'm sorry if I confused anyone if I misread the question.

Link to comment
Share on other sites
kareng Grand Master

Sorry, my post was in response to the question here:

Yes, any MD is able to the testing, as we are seeing only MDs for my daughter's dx quest.

I'm sorry if I confused anyone if I misread the question.

Great! Lots of stuff posted in between! :)

I see no reason her pediatrician couldn't test her blood for vitamins, etc.

I found this but it seems a bit extreme if you haven't had blood levels done first. Maybe something down the road if things don't improve?

Open Original Shared Link

Link to comment
Share on other sites

Archived

This topic is now archived and is closed to further replies.


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      120,480
    • Most Online (within 30 mins)
      7,748

    EJenkins
    Newest Member
    EJenkins
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.2k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • Tlbaked13
      Thank you and I am aware that I should be eating a "normal" diet until tested it's kind of been trial and error for my diet or more like just ERROR! I about 1-3 bites a meal I'm to a point that 99 percent of the time I'm having trouble swallowing just about everything occasionally I find either something or a very small window of time that allows me to get very little of something! I am basically getting zero nutrition what so ever because I take one bite of the meal that I usually just slaved over just to end up tossing it when it's all said and done...did anyone else ever experience anything like this?  I am more then open to suggestions! It is taking a very extreme toll on me and my body forsure 
    • JustGemi
    • trents
      No! Do not start the gluten free diet until you know whether or not you will be having an endoscopy/biopsy to verify the blood antibody test results. Starting gluten free eating ahead of either form of diagnostic testing can invalidate the results. You don't want to allow the villous lining of the small bowel to experience healing ahead of testing by removing gluten.
    • Scott Adams
      We offer a ton of recipes here: https://www.celiac.com/celiac-disease/gluten-free-recipes/ and have done some articles on fast food places, but keep in mind that eating out is a common source of gluten contamination: https://www.celiac.com/search/?q=fast food&quick=1&type=cms_records2 Many colleges now offer allergen-friendly, and sometimes gluten-free options in their student cafeterias: https://www.celiac.com/search/?&q=colleges&type=cms_records2&quick=1&search_and_or=and&sortby=relevancy PS - Look into GliadinX, which is a sponsor here, but many studies have been done on it which show that it may break down small amounts of gluten in the stomach, before it reaches the intestines.
    • JustGemi
      Thank you! What do you recommend in the next 7 weeks until I see my Doctor?  Just start my Gluten free diet?
×
×
  • Create New...