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      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Genetics And Celiac Symptoms
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11 posts in this topic

Hii Everyone, does anyone here have double copies of DQ2 ? And if so would you say your extra sensitive go gluten like some studies suggest ?

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I am double DQ2.  Yes, I consider myself super sensitive to gluten.  That is about all I know about it.

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Do doctors usually test for this DQ2 gene or do you have to request it?  I am really sensitive to gluten.  If I eat a cookie I feel like I have the flu within 45 minutes.  If I have my girls tested for the DQ2 gene will that mean they will eventually have Celiac Disease too?

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Do doctors usually test for this DQ2 gene or do you have to request it?  I am really sensitive to gluten.  If I eat a cookie I feel like I have the flu within 45 minutes.  If I have my girls tested for the DQ2 gene will that mean they will eventually have Celiac Disease too?

Yiu can request a gene test for HLA-DQ genes associated with celiac. If you have the gene there is a 50/50 chance that you kids have it too since they take one copy from each parent and each parent has two copies of HLA-DQ genes. If your kids test positive on the gene it doesnt mea they have celiac or thay they would definitely get celiac it just means that they are at a greater risk to get it than someone who doesnt have these genes especially if hey have double copies of celiac genes like my mom and aunt.

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I am double DQ2.  Yes, I consider myself super sensitive to gluten.  That is about all I know about it.

Which DQ2 genes do you have double DQ2.5 or DQ2.5 and DQ2.2 ?

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Yiu can request a gene test for HLA-DQ genes associated with celiac. If you have the gene there is a 50/50 chance that you kids have it too since they take one copy from each parent and each parent has two copies of HLA-DQ genes. If your kids test positive on the gene it doesnt mea they have celiac or thay they would definitely get celiac it just means that they are at a greater risk to get it than someone who doesnt have these genes especially if hey have double copies of celiac genes like my mom and aunt.

Thanks PersianCeliac, does your mom and aunt have celiac?  

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Thanks PersianCeliac, does your mom and aunt have celiac?  

Yes both were diagnosed around 9 months ago. My aunt who is 47 years old is very very thin and never gains weight and had a problem with chronic diarrhea for 16 years ! And lots of gas build up and GI symptoms until this doc sent her for celiac panel. Her numbers were off the chart ! And her biopsy showed total atrophy. I read about the disease and found it its genetic so decided to test my mom. My mom had no symptoms but her blood work came back waaaay off the chart ! It was a shock. Her bippsy showed subtotal atrophy.

When were you diagnosed ?

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Molecular Analysis of DQA1 Genotype Gluten Sensitivity Positive 04-18-12 0501 (HLA-DQ2) Yes 04-18-12 0301 (HLA-DQ8) Yes
Test Date Molecular Analysis of DQB1 Genotype Gluten Sensitivity Positive
04-18-12 0201
(HLA-DQ2) Yes 04-18-12 0302
(HLA-DQ8) Yes

Which DQ2 genes do you have double DQ2.5 or DQ2.5 and DQ2.2 ?

That is the best I can do.  That is all of my genetic results.  USA may not get so detailed results.

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Molecular Analysis of DQA1 Genotype Gluten Sensitivity Positive 04-18-12 0501 (HLA-DQ2) Yes 04-18-12 0301 (HLA-DQ8) Yes

Test Date Molecular Analysis of DQB1 Genotype Gluten Sensitivity Positive

04-18-12 0201

(HLA-DQ2) Yes 04-18-12 0302

(HLA-DQ8) Yes

That is the best I can do.  That is all of my genetic results.  USA may not get so detailed results.

You dont have double copies of DQ2 you have DQ2 and DQ8 which also means you could be very sensitive since you have both celiac genes.

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Yes both were diagnosed around 9 months ago. My aunt who is 47 years old is very very thin and never gains weight and had a problem with chronic diarrhea for 16 years ! And lots of gas build up and GI symptoms until this doc sent her for celiac panel. Her numbers were off the chart ! And her biopsy showed total atrophy. I read about the disease and found it its genetic so decided to test my mom. My mom had no symptoms but her blood work came back waaaay off the chart ! It was a shock. Her bippsy showed subtotal atrophy.

When were you diagnosed ?

Thanks.  I was diagnosed about 3 1/2 years ago.  

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You dont have double copies of DQ2 you have DQ2 and DQ8 which also means you could be very sensitive since you have both celiac genes.

This is interesting.  I wonder if this is why I get so sick.  I don't eat anything containing gluten but when I did before I would get very sick. 4 months after being diagnosed I decided to eat a donut and became very ill.   In a way it's good how sick I get because it keeps me from cheating.

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