Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Intro And Question
0

7 posts in this topic

Hi,   My name is Kris and we are very likely in the process of getting my 8yo DD diagnosed with celiac. Our Dr. sent her to an endocrinologist to investigate her short stature , (<1%) .  He ran blood work on her tissue transglutaminase iga was 1,992, a GI appointment in June and trying to learn as much as we can in the meantime.  

In the meantime I had a routine apt. with my gynecologist, and I asked him to run a tissue transglutaminase iga on me, since celiac tends to be genetic. (Although I don’t have any symptoms that I am aware of)  My # came out at 78 although my gynecologist does not really know what means.  I think that’s a positive result, but I can’t find much on the web to confirm.  I will call my primary care tomorrow.  But thought I’d ask you all tonight.  Thanks for accepting me into your group and thanks in advance for your input.

0

Share this post


Link to post
Share on other sites


Ads by Google:

Welcome to the community, Kristina.

Test ranges vary by lab, so having just the result number is not enough to offer an informed opinion. But my guess is that 78 on ttg IgA is very likely to be a positive in any case.

If positive, it is suggestive of celiac disease. The ttg IgA is indicative but not definitive. There are seven tests related to celiac disease that I am aware of, with one additional control that is not specific to celiac disease but validates the other IgA results.

Deaminated gluten tests are highly specific. There is some information about them here from the US NIH

0

Share this post


Link to post
Share on other sites

I'm no expert on test results, that part is complicated & best left to the doctors. However, what I can tell you is that I had no idea that I had issues until my 1 yr old was diagnosed. Our first assumption was that it stemmed from my husbands genetics (partially true) because he had years of undiagnosed problems. For me, I never would have guessed celiac, I suspected I had an underactive thyroid but thats it. Surprise surprise...after going gluten-free, I had more energy, lost weight & realized I had been bloated all the time & didn't know it, migraines disappeared, brittle fingernails grew strong, etc, etc. Celiac is a malabsorption issue & causes vitamin deficencies - thus the signs & symptoms vary by person & aren't always obvious gi symptoms. Good luck and keep in mind, its the only disease completely in your control - no drugs, just food!

0

Share this post


Link to post
Share on other sites

Welcome to the board.

 

As Peter said, it's hard to comment on test results without a lab range, but ttg ranges are usually up to about a 20 and a 78 is far beyond that, and  a 1992 is astronomically high. With ttg IgA tests that are soooo positive, there is little doubt that celiac is causing that result. When ttg test results are close to the normal range, the slightly positive result "can" be caused by other autoimmune diseases or sicknesses.

 

Waiting until June is a long time for your daughter to keep eating gluten when it makes her sick. Is it possible to get your daughter's appointment moved up?  If not, you might want to request the remaining celiac panel, and then reduce her gluten intake until a few weeks before seeing the GI specialist - he might want to schedule an endoscopic biopsy to check the intestinal damage, and if she is eating gluten-free the damage might heal by then.

 

The remaining celiac panel is:

  • ttg IgG (and ttg IgA)
  • total serum IgA (the control test Peter mentioned)
  • DGP IgA and DGP IgG
  • EMA IgA
  • AGA IgA and AGA IgG (these are older and less accurate tests)

You should have these tests done too. It sounds like you have it too even if you have no obvious symptoms (like headaches, achiness, fatigue or hairloss). Remember that the tests will be inaccurate if you stop eating gluten before doing them, so don't cut out gluten until you are satisfied that your testing is done.

 

Good luck with the future appointments and testing.  :)

0

Share this post


Link to post
Share on other sites

Thanks all for your input.  The endocrinologist ran a bunch of blood tests on my daughter because of her short statue.  The only ones in the “Celiac Panel” were the Immunglobulin A which came out at a 65 and the Tissue Transglutaminase IgA which was 1943.4 (my original post was from memory and slightly off)  I don’t like the idea of waiting until June because I don’t want to cause anymore damage to her body, but she had no other symptoms besides her height so she feels fine.  We are on a cancelation waiting list, so we will see if we can get in sooner.

  I asked my OBGYN to run the Transglutaminase test just to rule me out…never suspected a positive result.  I see my Primary care on Tuesday to follow up, maybe he will run a more extensive test.  He is my daughter’s Doc too so, I will ask him if we should run the rest of the panel suggested.  All this stuff is new to be, not really how I wanted to continue my education, but best to know now, and good that it is something controllable by a healthier diet not a lifetime on meds.  

Best to all of you.

0

Share this post


Link to post
Share on other sites




Also began wondering is I should be even more alarmed by the extreemly high Tissue Tranglutaminase IgA if 1942.3.  Really hoping it doesn't indicate anything more sinister than Celiac.  I will talk to the Primary care next week, but why do I always freak out on the weekends.  Has anyone ever even seen a value that high?

0

Share this post


Link to post
Share on other sites

Also began wondering is I should be even more alarmed by the extreemly high Tissue Tranglutaminase IgA if 1942.3.  Really hoping it doesn't indicate anything more sinister than Celiac.  I will talk to the Primary care next week, but why do I always freak out on the weekends.  Has anyone ever even seen a value that high?

I doubt it's anything else. Usually the more positive it is the more likely it is celiac, it's the low ttg tests that often show up with other problems.

 

Hang in there.  :)

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,110
    • Total Posts
      919,434
  • Topics

  • Posts

    • Hi Lisa, I completely understand why you didn't do a biopsy on your daughter.  I went through the appendix thing myself...not fun!  I was diagnosed with just bloodwork and no biopsy, but did have the full panel.  I would go back to your PCP and ask for a full panel to include TTG, EMA and DGP tests.  Since she was already willing to test you, I'm sure she would be willing to order these.  Good luck!
    • What a gross title–it bothers me and I wrote it! It wasn't my idea originally. The research paper the data came from was entitled, "Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease" published recently in the Journal of Allergy and Clinical Immunology. View the full article
    • katesyl.........this is an older topic so the OP most likely won't answer.  I can, however, offer a piece of advice for you. Just going gluten free will probably not drive your inflammation markers down into normal.  It does depend on how high they were to begin with but with all autoimmune diseases, there will be inflammation going on forever.  Get used to wonky blood work because most of us will have that issue. I have 4 autoimmune diseases in total and, although I have driven certain inflammatory markers way down, my recent sed rate number was elevated.  The normal is supposed to be 30 and under in a woman my age but mine is 50.  With 4 AI diseases, I doubt it will ever be normal and I don't let it bother me. I am not willing to take major meds at all and use more natural anti-inflammatory supplements.  You can do whatever you feel comfortable with in regards to treatment but don't expect normal numbers with Celiac Disease. Inflammation will improve but normal?  Most people never get there completely.
    • My daughter's PCP did not go against anything, she offered to do the biopsy - I was the one opposed to it. My DD, who was 10 at the time had just spent 3 weeks in the hospital, very sick with a ruptured appendix, then had 2 surgeries a few months after. I didn't see the need to put her through anything else with her numbers so high and all the classic symptoms. Apparently, in some other countries, if your numbers are all high, they forego biopsy. Anyway, I was really asking about myself and whether I should push for add'l testing. I am still new this this and trying to get up-to-date and wasn't sure if my PCP should conduct other blood tests before I go completely gluten-free. I have been somewhat gluten-free, but not entirely. I have no problem going gluten-free, but want to make sure that I am doing it for the right reasons. I wasn't sure if the Gliadin Abs IgA was sufficient to point to Celiac and possibly doing a biopsy for me. Or if additional blood test would make more sense.   Thanks!!
    • I would like to know if you have found out the source of your inflammation yet. I'm gluten free three years but my inflammation test was high.
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,148
    • Most Online
      1,763

    Newest Member
    MichaelDG
    Joined