Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Only Aga Iga Was High?
0

5 posts in this topic

Hi, I'm new here and trying to make sense of some lab results I received yesterday. I've had GI problems for about as long as I can remember (I'm 32 now) and every diagnosis that's been given so far has turned out to be wrong or only able to explain part of the problems I have. My new GI doc did a celiac panel that tested tTG, EMA, IgG and antigliadin IgA. The only one that was positive was antigliadin IgA, the normal range cutoff is 30 and mine was 49. He said that means I have celiac, but I was very skeptical that only one marker out of those 4 could give a definitive diagnosis and told him as much. So I requested more tests and he ordered the DQ2/DQ8 test and I will hear back on that next week.

 

Is it possible to have celiac with only the AGA IgA being high? Is there anything else he should be doing as far as tests? The crappy thing about my situation is that I'm losing my insurance on Monday due to divorce so the amount of time I have to look further into this is limited. I guess a trial on gluten-free diet would probably be my best bet after insurance runs out? Thanks!

0

Share this post


Link to post
Share on other sites


Ads by Google:

Yes you have celiac disease. IgA's the most recent, most valid test for it. They measure other tests because not all celiacs will be positive for the same things, eg: you might always have a low IgA, some genetic thing, in which case even with celiac disease it would be below the cut-off.

It's very confusing, but there's a ton of reading you can do , especially on this site, that explains the differences between all the tests and why some will be negative.

 

I think a more important question would be, why would your IgA be high if you don't have celiac disease?

0

Share this post


Link to post
Share on other sites

Thanks for the reply. I was under the impression that AGA IgA/IgG tests were the oldest tests (from the 70s) and the least clear cut of the tests (EMA and ttG being more reliable indicators of celiac).  If I'm misunderstanding this please let me know. The clearest information I've been able to find is this from another website: "The antigliadin tests are less specific for celiac disease, and these antibodies sometimes show up in other diseases (including gluten sensitivity)." That's why I'm hesitant to accept a celiac diagnosis from just this one AGA IgA positive marker.

0

Share this post


Link to post
Share on other sites

It's true that there's a newer test, the DGP IgA and IgG, with a much greater specificity for celiac and much more sensitive than the tTG in picking up early damage.  You could ask for this test to be run, but even were it not positive I would still be inclined to believe that you are indeed celiac since all it takes is one positive.  What symptoms does celiac not explain for you?

 

Welcome to the forum and I'm hoping you have found your answer.

0

Share this post


Link to post
Share on other sites

Hi Jorona,


I'm new too but I've been reading for a while.


You are correct, AGA-IgA and AGA-IgG is the older Celiac test.

In fact when I went to do the Celiac panel last week I was also supposed to be doing the AGA-IgA and AGA-IgG
but the lab no longer offered them and they told me it's now only DGP instead of AGA.

AGA-IgA and AGA-IgG is now used to test for Non Celiac Gluten Sensitivity when it's available.
Still it's good news that you now know that you have Gluten sensitivity.

 

Here is the up to date Celiac blood test panel::

TtG-IgA Transglutaminase IgA AB
DGP-IgA Deaminated Gliadin IgA
DGP-IgG Deaminated Gliadin IgG

and:     Total IgA  (to make sure your body is producing enough of the IgA immunoglobulin)

 

The above Celiac panel covers all the bases as some people test positive for one or 2 and not another.

 

 

 

 

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,352
    • Total Posts
      920,503
  • Topics

  • Posts

    • I already did. Thats how i found the place. Its amazing to actually go to a restraunt again.
    • This is EXACTLY what happens to me. It has twice now and both times was after both glutening episodes but once it was the day after and the other time it was a week and a half. So I'm still not sure if it's related or strange bug bites...

      Did they stop happening when she stopped being glutened? Did you decide they were definitely related? I'm really confused by this and would love to know whether to insecticide my house or....
    • Thankyou both! I was wondering if my high levels left much doubt on the diagnosis. I don't see the GI until the 15th Sep and I don't think I can stand to eat gluten in that time. If he tells me to I will do so after then. After 25 years of symptoms I don't think there is much chance of healing my bowel In a couple of weeks. I'm actually terrified of the damage they might find. But I think I will need the endo since there may be other things going on with me. So great they didn't put your son through the biopsy! Once I have a formal diagnosis I have my kids to worry about also. I can't even stand the thought of my daughter having a blood test. I think she would need to be sedated as she is so fearful and pain sensitive. My son is not yet 2 so I don't think they will test him. I'm feeling so off at the moment. I think I have some anxiety and reflux going on complicating things quite a bit.
    • My son's antibodies were 300. Based on his extremely high levels, his pediatric GI suggested genetic testing instead of the biopsy. Genetic testing can't diagnose celiac on its own but combined with such high levels, the gi dr was confident a positive genetic test would confidently diagnose celiac. He warned that biopsies are small snapshots of the intestine and can miss damage. He said this is an approach used very often in Europe but not as much in the US. What sold me on that approach was the ability to put my son directly on a gluten free diet instead of waiting three weeks for the biopsy, during which time he would continue to eat gluten and feel terrible. I'm not sure if this is more common with younger patients though (our son is two), based on the idea that he's had less time to inflict damage that would show in a biopsy? We are very happy that we immediately started the gluten free diet and chose the genetic testing. Our son got the proper diagnosis and his recent number shows a drop to 71 after only 4.5 months gluten free! Not sure if this helps. Good luck and I hope you feel better soon!
    • We have been off gluten for a while now, and symptoms return when I've allowed gluten full meals… so something still isn't sitting right with me.  Checking with her doc about seeing a pediactric GI although I'm not sure how long that will take since we live in small town America. I know she didn't get at least one of the recommended full panel tests but maybe two, can someone help clarify, or is she missing two? DGP for sure and possibly EMA? And if I understand what I'm reading in other posts that the DGP can be more accurate? Thanks Her blood panel results: Ttg ab iga <.5u/ml ttg igg <.8u/ml aga ab iga <.2 u/ml aga an igg <.7u/ml iga 61mg/dL  
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,417
    • Most Online
      1,763

    Newest Member
    Suzette Porter
    Joined