Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Diagnosis Help/ Genetic Markers
0

7 posts in this topic

Hey everyone,

I have experienced swelling/arthritis type in my joints(right ankle, knee, left wrist). Also had torn tendon in right foot with no specific trauma.

Many blood tests have taken with results normal, a few of the abnormals

35 iron,

21 vitamin D

Leukocyte s 12

Neutrophils 7.88

Monocytes 1.18

LgA <1.2

LgG 7.0(weak positive)

C reactive protein 67.9

Upper endoscopy revealed scalloping of duodenum with normal villi architecture. Biopsy showed higher white blood cells. At this point doc said I had celiac disease. My mother, also a physician got tested and showed negative genetic markers. My doc was unwilling to order genetic test and my mom ordered for me anyways. Here are the results:

Celiac Disease Interpretation

May 03, 2013

See comments

Show historical results

Permissive genes absent. Celiac disease extremely unlikely.

DQ alpha 1

01,02:01

Show historical results

Not Applicable

DQ beta 1

03,05

Show historical results

Not Applicable

Serologic Equivalent: 9,5

Celiac gene pairs present?

No

Show historical results

Method: Low to Medium or High Resolution Molecular Testing

Any help or thoughts would be extremely appreciated! :)

0

Share this post


Link to post
Share on other sites


Ads by Google:

Some stuff majorly out of whack with you, I'd fix the Vitamin D for a start since that's easy and something you can certainly control yourself. I'm pretty jealous of your massive Neutrophil count... I have almost none :)! well 1.8 usually, it's long way from 7.88.

 

I agree you are very unlikely to have a problem with celiac disease considering you have no genes for it. But that doesn't mean something else isn't messing with your gut/immune system. Get the Vitamin D up to 100+ and see what changes, that would be my first step.

0

Share this post


Link to post
Share on other sites

Unfortunately gene testing can be problematic if you don't have one of the two most common genes for celiac. That doesn't however mean you can't have it. My genes are a case in point. I am firmly diagnosed but lack either of those two genes. However in the Middle and Far East the genes I carry are considered to be associated with celiac. It can be very confusing but if you respond well to the diet you have the answer as to whether you should be on it regardless of what the genes you carry are, IMHO.

0

Share this post


Link to post
Share on other sites

Did you do a celiac panel such as this one:

 

Total IgA
Transglutaminase IgA      tTG-IgA 
Deaminated Gliadin IgA   DGP-IgA
Deaminated Gliadin IgG  DGP-IgG

 

 

Can someone explain to me how she can have: "scalloping of duodenum with normal villi architecture" ?

 

Why is the villi normal with the scalloping?    

 

Anyone know?

0

Share this post


Link to post
Share on other sites

Did you do a celiac panel such as this one:

 

Total IgA

Transglutaminase IgA      tTG-IgA 

Deaminated Gliadin IgA   DGP-IgA

Deaminated Gliadin IgG  DGP-IgG

 

 

Can someone explain to me how she can have: "scalloping of duodenum with normal villi architecture" ?

 

Why is the villi normal with the scalloping?    

 

Anyone know?

The damage to the villi can be patchy and easily missed. The scalloping can also be seen early on before severe villi damage is present.

0

Share this post


Link to post
Share on other sites




Don't believe that the celiac panel you are referring to was ordered. The only blood tests for that was what I already posted with lga and lgg.

Here is pathology report:

DIAGNOSIS:

A. Duodenum, second part, endoscopic biopsy: Patchy

intraepithelial lymphocytosis (30-50/100 epithelial cells) with

normal villous architecture. Plasma cells are present but there is

no increase in lamina propria inflammation and no foamy macrophages.

Comment: Increased intraepithelial lymphocytes with normal villous

architecture can be seen in symptomatic, latent or partially treated

gluten sensitivity (celiac sprue), dermatitis herpetiformis, and

first degree relatives of gluten sensitivity. Other associations

include systemic autoimmune disorders and NSAID use.

B. Duodenum, bulb, endoscopic biopsy: Chronic peptic type

duodenitis. There is focal equivocal increase in intraepithelial

lymphocytes.

0

Share this post


Link to post
Share on other sites

My case has been forwarded to a Celiac expert, so we will see what awaits.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      103,896
    • Total Posts
      919,537
  • Topics

  • Posts

    • Marshmallow Fruity Pebbles
      I have been gluten free now since February and I recently purchased a box of Marshmallows Fruity Pebbles and looked at the ingredients (which none indicated gluten content), but am just wondering if anyone has had a problem with them. 
    • Test Results
      Update: I am about at my wit's end. I won't be able to see my new doctor until July 17 to get a referral to a GI doctor, so I continue to eat gluten and the effects continue to worsen. Today my boss, whom I have been working with for 12 years, and I had a meeting where he said he's noticed a change in many things, such as speech, not articulating well, forgetfulness, and other things that are affecting my work product. I finally told him I know there is something wrong with me medically and I've been trying to get to the doctor to no avail. I recall those four weeks early in the year when I tried out gluten free and was beginning to feel much better- more present, more sharp, and then went back on gluten in preparation for the blood test.  I just don't think I can do this gluten thing any longer and am thinking of going cold-turkey gluten free.  I'm 54 years old, am beginning not to care about a diagnosis because I just want to feel better and be able to do what I need to do. Because of how I felt going off of gluten earlier in the year, and eating gluten free when I was on the McDougall plan years ago, and how I feel while doing this gluten challenge, I am pretty convinced that my issue is gluten.  Any words of encouragement would be welcome.  If you've done gluten free and never looked back, tell me about it. 
    • Gardasil
      "I got this vaccination in 2009 when I was 20 and it completely altered my life. Made my celiac disease so much worse, sleep 15-18 hours a day, SIBO, it has completely altered my life since getting this vaccination. My doctor has two twin girls about my age and they both have digestion problems after receiving gardasil Thank you I have a young daughter and have wondered this exact question posed by the poster and your response has given me great pause about this issue which may come up in years to come. I am sorry to hear this wreak havoc on your life, but simultaneously thank you for sharing this detail to help those of us that have likely been decades misdiagnosed celiacs now raising children. Thank you.
    • Gluten does WHAT to the brain?
      "Wondering what kind of life my brother could have had - if  he had celiac - constantly haunts me" My sympathies that is just tragic, as this story is.  I hope you are at peace knowing you are aware of your celiac and help so many lost, scared, and confused celiacs here. It can never bring back your brother but I hope it can give soften some of what you feel that was/is beyond your control. His suffering and your loss has made you a better advocate to yourself and in your work helping us. I don't like my body or my  brain on gluten either. I do fear that people overlook the toll inflammation takes on the brain. It likely may explain decades of mental illness that was brain based inflammation unknown until changes in technology advancement catch up. However consuming gluten to study how one enters psychosis may not be the best method. Do no harm.  
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

    • Jmg  »  admin

      Hello Admin!
      I don't know whether this is of interest to post on your articles feed:
      http://pratt.duke.edu/about/news/window-guts-brain
      Kind Regards,
      Matt
      · 2 replies
    • celiac sharon  »  cyclinglady

      Hello cycling lady, have you noticed my picture is showing up as you?  Have no idea why but it's rather disconcerting to see my picture and your words 😉  Do you know how to fix it?  You seem to have far more experience with this board than I do
      · 1 reply
    • Larry Gessner  »  cyclinglady

      Hi There, I don't know if there is a place for videos in the forum. I just watched "The Truth About Gluten" I think it is a good video. I would like to share it somewhere but don't know where it should go. Any help would be greatly appreciated.
      Here is the link if you have never watched it.
      https://youtu.be/IU6jVEwpjnE Thank You,
      Larry
      · 2 replies
  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      60,944
    • Most Online
      1,763

    Newest Member
    purplerain
    Joined