Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Does Gluten Always Cause A Reaction?
0

6 posts in this topic

I just have a few questions re the mechanisms of coeliac disease. I'm a zoology student with coeliac disease (and associated conditions....gluten really reaked havoc on my body!) so am interested in the science, but I've always struggled with  comprehending the biology of the immune system. Maybe it's because mine's so rubbish, ha :P

Do we ALWAYS react to ingested gluten? Or does it sometimes 'slip through the net'? Obviously most of the time the body does react to glutenings (and boy do we suffer!), but could there be occassional times where the immune system doesn't respond?

ie., are antibodies produced immediately upon every exposure to gluten? And does some level of damage always ensue?

Don't worry, I'm not considering 'cheating' on the diet, I'm just interested in the mechanisms. :)

0

Share this post


Link to post
Share on other sites


Ads by Google:

Hi Hala,    I wondered the same thing.

 

I had procastinated going back on gluten to do the blood tests for fear of a wave of pain.

But it didn't happen like when I tested it 2 months after going gluten free +2 years ago. 

 

Now I'm consistantly eating bread everyday but the pain isn't consistant so I don't know what is going on.

1

Share this post


Link to post
Share on other sites

This is not an area of celiac knowledge that I have spent a lot of time on, so my thoughts may not be 100% informed. They have, however, guided me through almost thirteen years of being diagnosed with celiac disease and following the gluten-free diet.

Some people with celiac disease do not experience any detectable symptoms, even though there is damage to the villi. These "silent celiacs" never notice a reaction.

Celiac disease is a contest. Gluten causes the immune system to react. The more gluten, the larger the reaction. The reaction produces antibodies. Sensitivity, and therefore production levels, vary from person to person. The tests have limits and are not able to reliably detect antibodies at low levels.

Our bodies want to heal, and the villi slowly regenerate. How quickly this happens varies with many factors. Key ones are that younger people seem to heal faster, and that the more serious the damage originally was, the longer it may take.

So what does that all mean? It seems to me that as long as your healing rate is moving faster than the damage is being done, you are winning the game.

 

But if you want blood tests to be accurate (your insurance will only pay once), don't play around. Eat lots of gluten (a slice or two of regular bread a day) over a period of several weeks prior to testing.

2

Share this post


Link to post
Share on other sites

Hi Hala,    I wondered the same thing.

 

I had procastinated going back on gluten to do the blood tests for fear of a wave of pain.

But it didn't happen like when I tested it 2 months after going gluten free +2 years ago. 

 

Now I'm consistantly eating bread everyday but the pain isn't consistant so I don't know what is going on.

 

Hiya :). Back when I was eating gluten I didn't have particularly consistent symptoms either, although if I ate a gluten-heavy meal I definitely suffered heavily afterwards! But sometimes I wouldn't feel much of a reaction at all, or would feel crap after a non-gluten meal. Maybe some of the symptoms have time-lags? Or perhaps whilst the antibodies are always present, the symptoms come in waves? Tbh I felt so awful so much of the time I'm not sure the symptoms ever truly subsided!

Good luck with the testing, I hope you can say goodbye to gluten soon :)

 

This is not an area of celiac knowledge that I have spent a lot of time on, so my thoughts may not be 100% informed. They have, however, guided me through almost thirteen years of being diagnosed with celiac disease and following the gluten-free diet.

Some people with celiac disease do not experience any detectable symptoms, even though there is damage to the villi. These "silent celiacs" never notice a reaction.

Celiac disease is a contest. Gluten causes the immune system to react. The more gluten, the larger the reaction. The reaction produces antibodies. Sensitivity, and therefore production levels, vary from person to person. The tests have limits and are not able to reliably detect antibodies at low levels.

Our bodies want to heal, and the villi slowly regenerate. How quickly this happens varies with many factors. Key ones are that younger people seem to heal faster, and that the more serious the damage originally was, the longer it may take.

So what does that all mean? It seems to me that as long as your healing rate is moving faster than the damage is being done, you are winning the game.

 

But if you want blood tests to be accurate (your insurance will only pay once), don't play around. Eat lots of gluten (a slice or two of regular bread a day) over a period of several weeks prior to testing.

Thanks for the info :). I've actually already been diagnosed (very positive blood tests and completely destroyed intestines...the gastroenterologist said they were the worst he'd seen :/) and have been gluten-free for 6 months now, so I don't need to worry about testing or whatnot (which is free in the UK anyway, lucky us!). I was just curious about the science behind the disease.

0

Share this post


Link to post
Share on other sites

I know from doing two gluten challenges and several accidental glutenings in the past year that my mileage really varies. Not only was the severity of my reactions quite different, so were the symptoms. I had a mild anaphylactic type reaction one time, and the next, I was terrified that eating pure wheat crackers would kill me, but they didn't. Just had the usual post-gluten stuff a few days later.

 

So in my experience, yes, it varies a lot.

 

And of course, in no way am I recommending experimenting with this for yucks, I just did it under my doc's supervision because we had such a rough time getting a diagnosis.

0

Share this post


Link to post
Share on other sites




I know from doing two gluten challenges and several accidental glutenings in the past year that my mileage really varies. Not only was the severity of my reactions quite different, so were the symptoms. I had a mild anaphylactic type reaction one time, and the next, I was terrified that eating pure wheat crackers would kill me, but they didn't. Just had the usual post-gluten stuff a few days later.

 

So in my experience, yes, it varies a lot.

 

And of course, in no way am I recommending experimenting with this for yucks, I just did it under my doc's supervision because we had such a rough time getting a diagnosis.

It'd be interesting to find out what causes the variation! Maybe it depends on the strength of our immune system at the moment of ingestion? Or the region of the intestines targetted?

Yep I would never experiment for 'yucks' :P. The destruction celiac disease reaped on my body led to me being hospitalised for several weeks on end this year. I'm still recovering from the awful damage and malabsoprtion, no way would I ever purposely make it worse!!! I want to feel better :(

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      103,394
    • Total Posts
      917,605
  • Topics

  • Posts

    • Can treatment for Giardia reverse active Celiac
      I haven’t found any large scale studies on this, but only a handful of individual case reports suggesting that in rare cases giardia can temporarily mimic celiac (both the serology & villous atrophy) until it is treated.   I think this is a  complex matter as giardia effects patients differently (most are asymptomatic whilst others suffer from chronic symptoms including malabsorption) for reasons that may not be well understood. In my case - My GI agrees that Giardia can directly cause villous atrophy that cannot be distinguished from Celiac.  As the healing of the villi can be a slow process, I will schedule a repeat endoscopy 6-12 months after my giardia was treated.   Ttg antibodies can also take 6-12+months to completely normalise, especially if the starting levels are high. 6 months would have elapsed at the end of this month, so will schedule a repeat test, hoping for a normal Ttg result to prove the theory.   I have decided to remain on a normal gluten diet until it can be proven that I’m a celiac and not just suffering from a giardia infection.  I have reason to be optimistic as my Gliadin IgA levels are negative (not iga deficient) and also given the sharp decrease in ttg levels 4 weeks after giardia was treated.
    • celiac disease is psychosomatic
      It took all of 3 years before ALL of my symptoms resolved and it was the neuro ones that were the last to go.  If you have been careful about your diet, then you may not be getting glutened as much as you think.  It sounds like you have been careful because you are questioning things you should question to get clarification on.  I am sure if you were doubtful, you would refrain from eating something until you know for sure. Neuro symptoms can last for much longer than other symptoms.  Please be patient because my last neuro symptom was the one that took 3 years.  Have you been tested for vitamin deficiencies?  The B vitamins are important for neuro health, especially B12.
    • Week late aftershock!?
      I had a similar problem, I was glutened after a meal out at the beginning of April and am still experiencing problems, obviously not as bad now, but bad enough.  I have also become intolerant to  xanthan gum since, which cuts down the foods I can eat even more. I'm already intolerant to dairy, soya, and a whole lot of other stuff.  Cyclinglady is right about the auto-immune disorders, and I've noticed I have similar problems to her.  I too, eat easy to digest foods until the glutening symptoms pass. The sinus infection might also be a reaction to the glutening, it effects people in different ways.
    • celiac disease is psychosomatic
      Thanks, I'll check out the information in the link. Do you remember how long you were on a gluten-free diet before your vertigo disappeared? I have been on the diet for 2 years, but I might be glutened from time to time since I am not an expert food label reader. My dizziness still persists.
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

    • Larry Gessner  »  cyclinglady

      Hi There, I don't know if there is a place for videos in the forum. I just watched "The Truth About Gluten" I think it is a good video. I would like to share it somewhere but don't know where it should go. Any help would be greatly appreciated.
      Here is the link if you have never watched it.
      https://youtu.be/IU6jVEwpjnE Thank You,
      Larry
      · 2 replies
    • ChiaChick  »  Peaceflower

      Hi Peaceflower, Just wanted to say thank you for the chat.
      · 0 replies
    • ukuleleerika

      Hello! I am new to this Celiac website... Is there anyone out there with Celiac AND extensive food allergies? My allergies include shellfish, dairy, eggs, cantaloupe, kiwi, mango, nuts, oranges, red dye, and more I can't think of. I went to the allergist about a year ago to see why I wasn't feeling well, and once everything was eliminated, I still didn't feel well. We did more testing to find out I had celiac as well as allergies to cattle as well as rye grass (I live on a farm basically). This was back in January 2016. I recently had my endoscopy with the gastroenterologist a week ago. I have no idea what to do or what to eat... So fish and potatoes for me!
      · 2 replies
  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      60,528
    • Most Online
      1,763

    Newest Member
    MooCow27
    Joined