Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

I Need Help Interpreting Blood Test Results!
0

12 posts in this topic

Hi all. I am new to this forum but am really excited to glean your knowledge! My doctor recently sent me for blood tests for celiac (chronic diarrhea since childhood, fatigue, depression, iron-deficiency anemia) and he says the results are negative. I was wondering if I could get your opinions as to what these results actually mean before I decide what to do next. Here are my results (I'm in Canada, if that makes a difference...):

 

IgA 1.32 g/L  RefRange: (0.70-4.00)

 

Anti-transglutaminase IgA    <1.0  U/mL   

 

(<7.0 is negative, 7.0-10.0 is weak positive, >10.0 is positive)

 

So I believe the first number is the total serum IgA, right? I am not deficient according to this. And the next number is the tTG-IgA, right? Again, big fat zero, or close to. So I take it to mean that it is a pretty clear negative for celiac. Does that seem to fit with the knowledge of all you here? My doctor says the next testing we could do is colonoscopy but he says he's doubtful anything will show up. Any advice on steps I can take to gain some more health? I feel like the medical community has kind of written me off (my previous doctor gave me a diagnosis of IBS) since tests are negative... thanks for your input and opinions!

Erin

0

Share this post


Link to post
Share on other sites


Ads by Google:

welcome  :)

 

you should ask for a complete celiac panel which consists of:

 

DGP iga/igg

TTG iga (already done)

TTG igG

EMA

Total iga serum (already done)

 

you produce enough iga, so that makes the result valid.  i've seen it quite a few times on here that IBS really stands for "I Be Stumped"  :P

 

ask for the complete panel because some people have only been diagnosed with one or two of the above tests as positive.  Celiac is diagnosed through an endoscopy and not a colonoscopy. At least 6 samples should be taken during the endoscopy.  do not go gluten free until all testing is complete.

 

hope this helps!

2

Share this post


Link to post
Share on other sites

welcome  :)

 

you should ask for a complete celiac panel which consists of:

 

DGP iga/igg

TTG iga (already done)

TTG igG

EMA

Total iga serum (already done)

 

you produce enough iga, so that makes the result valid.  i've seen it quite a few times on here that IBS really stands for "I Be Stumped"  :P

 

ask for the complete panel because some people have only been diagnosed with one or two of the above tests as positive.  Celiac is diagnosed through an endoscopy and not a colonoscopy. At least 6 samples should be taken during the endoscopy.  do not go gluten free until all testing is complete.

 

hope this helps!

Thanks so much for your reply! Yeah, my doctor says that since I am clearly not celiac, a colonoscopy is the next test to figure out the cause of the chronic diarrhea. I will definitely ask for the complete panel you posted - I still have a feeling that gluten may be the issue and I'd rather run a few more blood tests before I get a (probably pointless) colonoscopy. I'm sure I'll be back after my results are in to get advice then as well. Thanks again for responding!

0

Share this post


Link to post
Share on other sites

So my doctor sent me for all the tests that were suggested here - wonderful that he was so willing to check it all out! There was a problem at the lab though when I went to get blood drawn. They said that the DGP tests didn't come up in the system so they couldn't run those. How important are these tests in diagnosing? Thanks so much!

0

Share this post


Link to post
Share on other sites

I have to use Labcorp for my insurance and a complete celiac panel for them consists of the tests I listed above.  On the other hand Quest Diagnostics says DGP are still considered experimental.   come to a consensus people  :)  what lab are you having them done through?  is labcorp an option for you?

 

check out page 12 of the report for specificity and sensitivity for DGP tests.  

 

http://www.worldgastroenterology.org/assets/export/userfiles/2012_Celiac%20Disease_long_FINAL.pdf

 

 

others on the board say that DGP picks up early celiac.  my biopsy was negative, but my DGP igg was double the normal amount of antibodies, and since damage wasn't found on my biopsy, I've decided early celiac it is  :)

 

here are some other threads I've started that deal more with DGP:

http://www.celiac.com/gluten-free/topic/100245-other-known-causes-of-high-dgp-igg-besides-celiac/

http://www.celiac.com/gluten-free/topic/101686-chicago-celiac-center-response-regarding-dgp-and-ttg/

 

the chicago thread is contradictory...Chicago response, "if it was only gluten intolerance (now we call it "non-celiac gluten sensitivity") DGP shouldn't be present. We are not aware of any research showing that a high DGP score with a negative ttG may represent early-onset celiac. A negative TTG and a negative biopsy essentialy do rule out celiac. Why is DGP-IgG elevated then? I don't know: but no test is - if taken alone - 100% diagnostic of anything in medicine."

 

I stand by early celiac no matter what they say  :)

0

Share this post


Link to post
Share on other sites




Thanks so much for your reply! Yeah, my doctor says that since I am clearly not celiac, a colonoscopy is the next test to figure out the cause of the chronic diarrhea. I will definitely ask for the complete panel you posted - I still have a feeling that gluten may be the issue and I'd rather run a few more blood tests before I get a (probably pointless) colonoscopy. I'm sure I'll be back after my results are in to get advice then as well. Thanks again for responding!

 

If you do go for a colonoscopy, you might want to request an endoscopic biopsy be done at the same time. There are a few members around here whose enlightened doctors did an endoscope at the same time as an exploratory colonoscopy, and they were surprised by a positive endoscopic biopsy. Celiac blood work isn't always positive - I believe there is up to a 25% false negative testing rate.

 

Good luck!  :)

0

Share this post


Link to post
Share on other sites

If you do go for a colonoscopy, you might want to request an endoscopic biopsy be done at the same time. There are a few members around here whose enlightened doctors did an endoscope at the same time as an exploratory colonoscopy, and they were surprised by a positive endoscopic biopsy. Celiac blood work isn't always positive - I believe there is up to a 25% false negative testing rate.

 

Good luck!  :)

Thanks - that's good advice. If I'm going to go through the hassle of a colonoscopy I may as well have the endoscopy done too! Thankfully my doctor is usually willing to work with me on things so I'm sure he'd agree :)

 

I have to use Labcorp for my insurance and a complete celiac panel for them consists of the tests I listed above.  On the other hand Quest Diagnostics says DGP are still considered experimental.   come to a consensus people  :)  what lab are you having them done through?  is labcorp an option for you?

 

check out page 12 of the report for specificity and sensitivity for DGP tests.  

 

http://www.worldgastroenterology.org/assets/export/userfiles/2012_Celiac%20Disease_long_FINAL.pdf

 

 

others on the board say that DGP picks up early celiac.  my biopsy was negative, but my DGP igg was double the normal amount of antibodies, and since damage wasn't found on my biopsy, I've decided early celiac it is  :)

 

here are some other threads I've started that deal more with DGP:

http://www.celiac.com/gluten-free/topic/100245-other-known-causes-of-high-dgp-igg-besides-celiac/

http://www.celiac.com/gluten-free/topic/101686-chicago-celiac-center-response-regarding-dgp-and-ttg/

 

the chicago thread is contradictory...Chicago response, "if it was only gluten intolerance (now we call it "non-celiac gluten sensitivity") DGP shouldn't be present. We are not aware of any research showing that a high DGP score with a negative ttG may represent early-onset celiac. A negative TTG and a negative biopsy essentialy do rule out celiac. Why is DGP-IgG elevated then? I don't know: but no test is - if taken alone - 100% diagnostic of anything in medicine."

 

I stand by early celiac no matter what they say  :)

I'm actually in Alberta, Canada so Labcorp is not a possibility. I went in to the lab today (our lab is Dynalife) and they actually phoned the provincial lab to see if there was a different code for it or something and they did say the test was available... the woman who drew my blood said it came up as amidated as opposed to deamidated. I'm kind of thinking they didn't run the correct test but we'll see. At least they tried! Whatever my tests results are, I am going to go gluten free. If I feel better off gluten then I know I will need to stay off of it. I was just hoping that there would be a clear medical diagnosis because it would make it easier to explain to family. I think my kids have issues with gluten as well so it would be easier to have a positive result as opposed to the vague "gluten intolerance" diagnosis that makes people roll their eyes. But hey, I'll do what I have to do to keep my kids and myself happy whatever the case :). I appreciate the help!

0

Share this post


Link to post
Share on other sites

I'm in Alberta too.  My doctor (before i realized doctors aren't all experts on celiac disease - my bad) ordered the "celiac panel" and it was just the tTG IgA, total serum IgA, and EMA IgA; I think they only went ahead with the EMA because I ended up with a high tTG IgA... I am one of the "lucky" ones that had very clear cut lab results. Anyway, I don't think the labs up here are very up to date when it comes to celiac disease.

 

Good luck with the gluten-free diet (after your endoscopy) for you and your family. My kids all tested negative but a couple appear to have issues with gluten (symptoms resolved on a gluten-free diet) so we made the house gluten-free. It's a bit tricky when we are out and they want a treat, but I think making kids gluten-free (especially if they have noticable symptoms) is worth it in the long run.

0

Share this post


Link to post
Share on other sites

I'm in Alberta too.  My doctor (before i realized doctors aren't all experts on celiac disease - my bad) ordered the "celiac panel" and it was just the tTG IgA, total serum IgA, and EMA IgA; I think they only went ahead with the EMA because I ended up with a high tTG IgA... I am one of the "lucky" ones that had very clear cut lab results. Anyway, I don't think the labs up here are very up to date when it comes to celiac disease.

 

Good luck with the gluten-free diet (after your endoscopy) for you and your family. My kids all tested negative but a couple appear to have issues with gluten (symptoms resolved on a gluten-free diet) so we made the house gluten-free. It's a bit tricky when we are out and they want a treat, but I think making kids gluten-free (especially if they have noticable symptoms) is worth it in the long run.

Thanks nvsmom. Apparently the labs here aren't good either. They only had the tests you mentioned and they didn't even run the EMA since my tTG IgA was negative (my doctor saw the celiac panel list I brought in and agreed to send me for all the blood tests I could get). The paperwork says, "REQUEST CANCELLED. Not indicated. ATTG test has greater sensitivity for Celiac disease. If clinical suspicion is high, EMA may be approved." So I guess a doctor asking for a test to be run isn't reason enough for the lab to run the test... I have been unwell my entire life and this is what I continually come up against. I'm just ready to give up. I have a question about a test they ran - I think it's my total serum IgA and IgG - am I right? It says...

IgA 1.47 [0.70-4.00] g/L

IgG 8.64 [6.94-16.18] g/L

 

Anyway, thanks for listening to me rant. I appreciate the input :)

0

Share this post


Link to post
Share on other sites

Yes, that looks like total serum immunoglobulin A and G. Both look good if just a tad on the low side.

Did you have your kids tested? You said they appeared to have a gluten sensitivity too. You probably should get them tested to check (unless you are planning on making them strictly gluten-free regardless of any tests). Plus, if they are positive, then you can be pretty sure that you are a celiac even if you are serologically negative in the one tTG IgA test, and I believe 5-25% of celiacs are.

Good luck with the gluten-free diet! :)

0

Share this post


Link to post
Share on other sites

Yes, that looks like total serum immunoglobulin A and G. Both look good if just a tad on the low side.

Did you have your kids tested? You said they appeared to have a gluten sensitivity too. You probably should get them tested to check (unless you are planning on making them strictly gluten-free regardless of any tests). Plus, if they are positive, then you can be pretty sure that you are a celiac even if you are serologically negative in the one tTG IgA test, and I believe 5-25% of celiacs are.

Good luck with the gluten-free diet! :)

Thanks - do you think the fact that the IgG and IgA are on the low side is an issue? I have an appointment with my kids' paediatrician tomorrow. My oldest doesn't seem to have any symptoms of celiac (other than reflux) but my younger two have some things I'm concerned about. I'll see if he's willing to have them tested. We stopped our gluten-free diet (well, it was more a gluten-light diet) so the testing won't be off because of that. Hopefully we'll either get some answers or soon be done with testing so we can go gluten free anyway! Again, thanks for your post :)

0

Share this post


Link to post
Share on other sites

I am guessing (and this is only a guess) that your low/normal IgA and IgG would not affect the tests. It is possible for those with very normal IgA to get a negative on the tTG IgA. In fact, most celiacs do not test positive on all the tests, that is why they run so many - doctors won't admit that though.

 

Many who are negative on the tTG IgA are positive in the demaninated gliadin peptide tests (DGP's) but I honestly doubt it is available in Alberta. I have yet to hear of anyone getting it up here. It may be available but doctora might not realize that it is a good alternative to the tTG tests. It is actually thought to be a superior test for kids - you might want to ask the doctor about it's availability.

 

Here is a great report from the World Gastroenterology Organisation on their Celiac Practice Guidelines. It discusses the tests, how sensitive and specific to celiac they are on pages 11-12. It's a good one to show doctors if you need back-up. http://www.worldgastroenterology.org/assets/export/userfiles/2012_Celiac%20Disease_long_FINAL.pdf

 

Good luck.  :)

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      103,641
    • Total Posts
      918,437
  • Topics

  • Posts

    • Anxiously waiting
      Thanks heaps. I will def be going private if the wait is too long. I have done a little research but i thought a gluten intolerance and coeliac was the same lol. My iron levels are just below average apparently but she said not bad enough for me to be this tired.
    • Celiac.com: Traveling While Gluten-Free? What To Consider From Someone with Celiac Disease
      There are a few definite truths about living gluten-free: You miss bagels every day. Curious friends regularly badger you with questions like “is ... View the full article
    • How effective is HD skin biopsy after being gluten free for a year
      DH is celiac disease that appears on the skin (gluten triggered).  It does not appear when you are consuming dairy, which sounds like a separate issue for you.   A DH biopsy requires active lesions (new/fresh) from consuming gluten.  So, if you want to be tested via a skin biopsy you must go back on gluten.  Finding a dermatologist who knows exactly how to biopsy for DH is often difficult.  Be sure your Derm is knowledable and has biopsied for DH before. Why no endoscopy for now?  I bet your GI  knows that your insurance will deny the endoscopy.  After all, you tested negative to the blood panel.  Your GI should not even ordered the blood panel knowing that you had been gluten free for months.  You have to be consuming gluten daily for 8 to 12 weeks for the blood test to be accurate.   Did you ever test positive?  Why did your primary diagnose you?  Having the gene just means you can develop celiac disease.  Some 30% of the population carries the genes.  The gene test should only be used to help rule out celiac disease.  
    • How effective is HD skin biopsy after being gluten free for a year
      No one can say exactly how long you might be able to get a positive dh biopsy after having been gluten free as long as you have been. The Chicago Celiac Disease Center says this: http://www.cureceliacdisease.org/faq/im-scheduled-to-have-a-skin-biopsy-to-screen-for-celiac-disease-should-i-maintain-a-gluten-containing-diet-similar-to-those-who-are-being-screened-via-blood-or-intestinal-biopsy/ http://www.cureceliacdisease.org/faq/what-is-a-gluten-challenge/ You said you had a flare of the plaque psoriasis -- that is NOT dh so why do you think the dh biopsy will show positive? Testing positive for the celiac genes does not mean you have celiac disease. 30+% of the population have the celiac genes but only very, very small fraction of those people do or will present with celiac disease. The gene tests are only used to rule OUT celiac NOT to diagnose it. Frankly, I can understand why your GI does not put any stock in your Primary doc's thinking you have celiac disease. A positive celiac gene and the boils in your armpits which the GI never saw and were never biopsied for dh but they resolved on a gluten free diet and so did your plaque psoriasis. That's all the GI has to go on. I don't know why you are pushing an endoscopy. If you've been eating strictly gluten free then an endoscopic biopsy for celiac will be negative.  Your PCP should have done a celiac blood panel on you back when you were still eating gluten rather than dx you based on the celiac gene you tested positive for.
    • How effective is HD skin biopsy after being gluten free for a year
      I've been gluten free for a year now and my gastro wants to wait for the endocopy until I'm eligible for the colonoscopy when I turn 50 later this year. I don't think she believes I have celiac, even though I tested positive for one of the genes associated with celiac and my primary has diagnosed me as having celiac. The gluten sensitivity blood tests came back negative, of course, since I was gluten free for 9 months at that time. Why is she waiting? At any rate, My digestive system has improved greatly, but when I reintroduced non fat Greek yogurt in my diet, the plaques psoriasis returned on my elbows. My primary believes it is dermatitis herpetiformis (as well as I, since before going gluten free, I used to get boils in my armpits) and I'm scheduled for a skin biopsy in 3 weeks. However, I eliminated dairy from my diet 4 weeks ago and the plaques psoriasis is healing like it did when I eliminated gluten from my diet a year ago. If the scar is reduced to eczema, does that mean there still are IGA deposits in my skin? I don't want to resume dairy since I experienced a cross reaction to the casein in cheese and found lactose was on that same list. So my question is, how long do the granular IGA deposits remain in the skin in order to have a valid skin biopsy test performed for dermatitis herpetiformis? Since it takes 1-2 years for dermatitis herpetiformis to heal on a gluten free diet and I just had a recent flare up, can I continue on my dairy free diet or should I resume eating non fat Greek yogurt for the next 3 weeks just for this skin biopsy?
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

    • celiac sharon  »  cyclinglady

      Hello cycling lady, have you noticed my picture is showing up as you?  Have no idea why but it's rather disconcerting to see my picture and your words 😉  Do you know how to fix it?  You seem to have far more experience with this board than I do
      · 1 reply
    • Larry Gessner  »  cyclinglady

      Hi There, I don't know if there is a place for videos in the forum. I just watched "The Truth About Gluten" I think it is a good video. I would like to share it somewhere but don't know where it should go. Any help would be greatly appreciated.
      Here is the link if you have never watched it.
      https://youtu.be/IU6jVEwpjnE Thank You,
      Larry
      · 2 replies
    • ChiaChick  »  Peaceflower

      Hi Peaceflower, Just wanted to say thank you for the chat.
      · 0 replies
  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      60,732
    • Most Online
      1,763

    Newest Member
    SueJ
    Joined