Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×

  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.



  • Celiac.com Sponsor (A1):

    Celiac.com Sponsor (A1-M):

  • Get Celiac.com Updates:
    Support Celiac.com!
    eNewsletter
    Donate

Help Me Interpret Test Results?

OmgTaylor

Recommended Posts

OmgTaylor Newbie
OmgTaylor
Posted

So I was told I didn't have celiac but started a gluten free diet anyway. I feel better when I don't eat gluten but I cant stop thinking about whether I have celiac or not. Can anyone interpret these results, also did my doctor even do thorough enough testing? Thanks in advance.

 

Endomysial Antibody IgA: Negative

t-transglutaminase IgA: <2     (Negative 0-3, Weak Positive 4-10, Positive >10)

Immunoglubulin A, Qn, Serum: 121mg/dL   (Expected range 91-414)

 

Link to comment
Share on other sites
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Deaminated Marcus Apprentice
Deaminated Marcus
Posted

Welcome to the forum OmgTaylor,

 

You do have enough Total IgA blood serum.

 

How long were you eating bread-gluten prior to the blood tests?

 

Did the doctor do an upper endoscopy and biopsy?

 

One more blood test would be the DGP-IgG.

 

Sometimes it's positive when the other blood tests are negative.

Link to comment
Share on other sites
nvsmom Community Regular
nvsmom
Posted

That's a pretty common partial celiac panel that many doctors run, that's what they ran on me too.  As Marcus said though, it is not the complete panel. There is also:

  • deaminated gliadin peptides (DMG IgG and DGP IgA)
  • anti-tissue transglutiminase (tTG IgG - you had tTG IgA done)

So far, your celiac tests are negative. It is possible to have some negative tests and other positive tests so you might want to request the DGP IgG - it is one of the most specific tests to celiac out there, pretty sensitive to the disease too.

 

For the tests to be accurate, you must be consuming gluten (1-4 slices of bread or the equivalent) for 4-12 weeks prior to blood testing, or 2-4 weeks prior to endoscopic biopsy.

 

If your blood tests all end up negative, you could request an endoscopic biopsy; that catches some cases of celiac disease that blood tests miss.  It's not common but it happens.

 

There is a good chance that you are Non-celiac Gluten Intolerant (NCGI) which means you have all the same horrible symptoms of celiac disease minus the intestinal villi damage, so there is no reliable way to test for that disorder besides the gluten-free diet.  After you have decided that your testing is complete, you should probably try out the gluten-free diet for at least 3 months and document how your symptoms change.

 

Best wishes, and welcome to the board.  :)

Link to comment
Share on other sites
OmgTaylor Newbie
OmgTaylor
  • Author
Posted

Another thing that might be relevant is that I've also been diagnosed as folic acid deficient and vitamin d deficient. 

 

 

Welcome to the forum OmgTaylor,

 

You do have enough Total IgA blood serum.

 

How long were you eating bread-gluten prior to the blood tests?

 

Did the doctor do an upper endoscopy and biopsy?

 

One more blood test would be the DGP-IgG.

 

Sometimes it's positive when the other blood tests are negative.

I hadn't purposefully gone gluten-free at the point these tests were conducted. Does total IgA Serum indicative of celiac or can it be indicative of something else? I haven't done an endoscopy because the doctor was pretty much done with me after all my tests were negative. I left feeling very crest fallen and haven't really been in the state of mind to consider perusing this further for the past six months besides random bouts of following the gluten free diet.

Link to comment
Share on other sites
frieze Community Regular
frieze
Posted

Another thing that might be relevant is that I've also been diagnosed as folic acid deficient and vitamin d deficient. 

 

 

I hadn't purposefully gone gluten-free at the point these tests were conducted. Does total IgA Serum indicative of celiac or can it be indicative of something else? I haven't done an endoscopy because the doctor was pretty much done with me after all my tests were negative. I left feeling very crest fallen and haven't really been in the state of mind to consider perusing this further for the past six months besides random bouts of following the gluten free diet.

the only reason for doing the "total" IgA is to determine that you make enough so that the testing valid.  If you can't get the DGPs run, the only thing you can do is trial the diet.

Link to comment
Share on other sites
nvsmom Community Regular
nvsmom
Posted

As I understand it, the IgA is just once aspect of your immune function. IgG, IgM, and IgE are further parts.

I do not believe a low IgA is usually cause for concern.

Try not to let your negative tests discourage you from figuring out what is wrong. Because you are low in IgA, you have not yet had any tests that can tell you if you ave celiac or not. It is almost like giving a blood glucose test to a woman to find out if she is pregnant.... Not helpful at all. You need the right test.

Don't go gluten-free until you are done testing.

Link to comment
Share on other sites
taynichaf Contributor
taynichaf
Posted

I had these results come out negative too.... Then I decided to go to a different doctor and get ALL the tests done... But she ran the same exact test :/ Which came back negative again. But that doctor got me in to get an endoscopy, so I can't complain too much. Now just waiting for those results... I was going to try and go to another doctor and get the tests, but I'm so tired of feeling like this, and gluten makes my depression reallllly bad..

 

So, don't give up yet! Write down the other tests and bring them to your doctor. Ohh, and try to get them to listen to you...

Link to comment
Share on other sites
Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):

Celiac.com Sponsor (A8-M):


Deaminated Marcus Apprentice
Deaminated Marcus
Posted

Well said nvsmom and taynichaf. :)   

Link to comment
Share on other sites

Archived

This topic is now archived and is closed to further replies.

Go to topic listing
  • Celiac.com Sponsor (A19):


  • Member Statistics

    • Total Members
      120,988
    • Most Online (within 30 mins)
      7,748
    Jenny B.
    Newest Member
    Jenny B.
    Joined
  • Celiac.com Sponsor (A20):

  • Forum Statistics

    • Total Topics
      120.3k
    • Total Posts
      1m
  • Celiac.com Sponsor (A22):



  • Celiac.com Sponsor (A21):


  • Upcoming Events

  • Posts

    • TessaBaker
      Hair loss

      By TessaBaker · Posted

      It sounds like you're dealing with a complex situation, and I can understand how frustrating it must be not to have a clear answer. Gut health can indeed play a significant role in various aspects of our well-being, including hair health.
    • Celiac16
      Thiamine supplementation

      By Celiac16 · Posted

      I have found similar benefits from thiamine. I was diagnosed with celiac at 16 and never really recovered despite strict gluten and dairy free diet and no detectable antibodies on checkup bloodworks. I’ve tried stopping the b1 but start to feel bad again- I wanted my doctors to do more extensive testing for the different thiamine transporters and enzymes which would be a better indication if I was deficient or dependent on it but everyone dismisses it (there are know genetic mutations where you need to take it daily for life). I have looked into Thiamine Responsive Megablast Anemia and I have a lot of the more mild symptoms of the disease that manifest when thiamine isn’t given to the patient such as optic neuritis… I just find the parallels interesting. i think that celiacs could be a side issue of inflammation that resulted from vitamin deficiencies. I was eating a lot of sugar leading up to my diagnosis and since eating gluten free didn’t make me feel much better, I’m wondering if this was more the underlying issue (sugar heavily depletes b1). I usually take 1.5g thiamine a day.
    • Fluka66
      Waiting for urgent referral.

      By Fluka66 · Posted

      Thank you for your welcome and reply.  Yes I've been carefully reading labels looking for everything in bold and have been amazed by what I have seen. However Heinz tomato and basil soup is wheat free so I m thinking I already have ulcers?  The acid could be causing the pain . My pain always starts in one place then follows the same route through me . GP confirmed that is the route of our digestive system.  So much pain from stabbing to tearing. If I throw in milk with lactose it's horrific.  Many years of it now, won't go into details but been seeing a consultant for a supposedly different problem . Wondering what damage has been done over the years. Many thanks for your reply. Wishing you the very best.    
    • trents
      Waiting for urgent referral.

      By trents · Posted

      Welcome to the forum community, @Fluka66! Did you realize that the vast majority of all canned soups use wheat starch as a thickener, including such common commodities as Campbell's tomato soup?
    • Fluka66
      Waiting for urgent referral.

      By Fluka66 · Posted

      Hello. Any help would really steady my nerves right now. I realised recently that certain food left me in agonising pain so eliminated from my diet. I also have a swollen lymph node. My very caring Dr did some blood tests and I went back the other day to see another equally caring Dr . She looked at the test results one result has come back with something wrong. It came very fast so I'm afraid I didn't catch what it was. Anyway the urgent referral to ENT. She did say as I had already eliminated gluten it wouldn't say anything on the results and neither Drs nor I were prepared to reintroduce gluten . I've just had some tomato soup and again in agony only thinking this must have aggravated maybe existing problems. Does anyone know what I'm facing now ? My swollen lymph node , pain when eating gluten and lactose and I'm assuming the acidity of tomatoes triggering pain.  I'm trying to stay calm and to be honest I've been in intolerable pain at times rendering me unable to stand up straight but I've always just got on with it . Guess I'm reaching out and would really appreciate any wise or unwise words at this stage. Wishing you all the very best as you live with this illness. Fluka66  
×
×
  • Create New...