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Help Interpretting Results

diagnosis lab results

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#1 tasha71577

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Posted 28 May 2013 - 11:54 AM

I was recently told by my doctor I might have Celiacs. He is not pushing for a biopsy but won't give me a difinitive answer.here are the lab results

 

Endomysial Antibody, Iga  - Negative

Deamidated Gliadin Abs, Igg 2 (normal 0-19)

T-Transglutaminase (Ttg) Igg  <2 (normal 0-5)

T-Transglutaminase (Ttg) Iga <2 (normal 0-3)

Deamidated Gliadin Abs, Iga HIGH 132 (normal 0-19)

Immunoglobulin A, Qn, Serum HIGH 981 (normal 91-414)

 

I also have Crohn's disease diagnosed in 1998 and confirmed through biopsy. Not sure if that could skew these results. The testing was done by LabCorp.  Any help or guidance would be greatly appreciated.

 


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#2 Deaminated Marcus

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Posted 28 May 2013 - 01:15 PM

Welcome to the forum Tasha,

 

page 12 of the World Gastroenterology Organisation Global Guidelines of April 2012,

 

http://www.worldgast..._long_FINAL.pdf


 says that DGP-IgA has a specificity of 93 to 96%

so that sounds good enough for me to send you for an endoscopy.

 

I don't know what more proof your doctor needs to send you for the endoscopy when there are people

on this forum who had negative blood tests and still get sent for an endoscopy.

 

Based on this article:  http://www.ncbi.nlm....pubmed/22643316

You should ask your doctor for blood tests for your liver and an utlrasound of your liver.

 

Good luck and keep us posted.


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#3 tasha71577

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Posted 28 May 2013 - 02:21 PM

Welcome to the forum Tasha,

 

page 12 of the World Gastroenterology Organisation Global Guidelines of April 2012,

 

http://www.worldgast..._long_FINAL.pdf

 says that DGP-IgA has a specificity of 93 to 96%

so that sounds good enough for me to send you for an endoscopy.

 

I don't know what more proof your doctor needs to send you for the endoscopy when there are people

on this forum who had negative blood tests and still get sent for an endoscopy.

 

Based on this article:  http://www.ncbi.nlm....pubmed/22643316

You should ask your doctor for blood tests for your liver and an utlrasound of your liver.

 

Good luck and keep us posted.

Thank you for this information. Does specificity mean that it is 93 to 96 % accurate at predicting people with Celiacs when confirmed by endoscopy?

 

As for liver function, I have my liver function tested every three months due to some of the meds I take for my Crohn's. I also forgot to mention that I was very deficient in Vitamin D.


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#4 Deaminated Marcus

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Posted 28 May 2013 - 02:32 PM

My understanding is that the Celiac blood test's specificacy listed are for detecting Celiac prior to an endoscopy.

 

For vitamin D, do get tested for D1.25 as my D .25 was low normal but my D 1.25 was too high.

 

I don't know if the meds are causing your single DGP-IgA positive results but do read the article posted.

That test result pattern has an association with liver problems. 

Good luck.


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