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New With Questions Regarding Lab Work


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#1 flo127

 
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Posted 12 October 2005 - 06:17 PM

Hi. I am hoping someone here can offer me some feedback and guidance. I am a 46 year old female who has Type 1 diabetes and Hashimoto's Thyroiditis. Recently I met with my endo and asked him to run some blood work for celiac disease as I have been having some symptoms that are suspicious. It seems he only tested for gliadin antibodies.

Here are my results: Gliadin Ab.,IgG <1.0 EU Limits -<25.0
Gliadin Ab.,IgA 33.9 EU Limits<25.0

Equivocal (25.1-49.9)

Since I fall in the equivocal range, what does this mean?? He advised me to follow up with a gastroenterologist. The soonest I could get an appointment is November 8th. When I see the gastro is there any additional blood work that should be ordered ? Would an endoscopy be warranted based on these results?? Are there any other diseases besides celiac that would cause my Gliadin IgA to be elevated?? Any feedback would be greatly appreciated.
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#2 FaithInScienceToo

 
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Posted 12 October 2005 - 10:04 PM

Hi.

I am surprised no one else has answered this post yet...

I will try to help, but I tend to shy-away from this type of question, as others on here seem to be more up on this blood-test stuff, or have the info more readily at hand to share it...

Anyway...Let's see...your results were:

Gliadin Ab.,IgA 33.9 EU Limits<25.0
and the lab your doc used stated that "Equivocal" for them is within this range: (25.1-49.9)

Well...when they say 'equivocal' it pretty-much means 'probable weak positive' versus 'definite positive,' meaning they cannot clearly 'call it positive'...

BUT, the facts that you already 'have' Type I diabetes AND thyroid problems are big red flags for Celiac, when you coupled them with a weak positive IgA (as IgA antibodies more specific to Celiac than IgG).

I am not sure if other illnesses can cause your "anti-gliadin IgA" result to be elevated...That's the IgA you were tested for, btw (if you were told you got tested for Celiac disease)- it's a test for the anti-body levels in your blood against gliadin, the protein that causes the immune system to attack the villi in Celiacs, as it tries to attack the gliadin (mistakenly thinking it is a virus).

Well....Nov 8th is not too far away, and it's good that you did not have to 'fight' to get to see a GI doc, like some people have to. I hate when I read that...

Anway, your Gastro will most probably want to do an endoscopy w/biopsies, because most of them want to, since it is still considered to be 'what is expected of them by their peers,' so do NOT stop ingesting gluten - but, also do not go 'hog-wild, either...just eat some every day beforehand.

AND, be sure you print out the following article for your GI!:

Gluten-Free Diet Recommended for Patients with Serum IgA Endomysial Antibodies but Normal Duodenal Villi Biopsy, because he/she may just skip the endoscopy altogether!

I found it on a page at this site, actually, at:

http://www.celiac.co...-59105052178.77

Also, ask him/her to rerun those 2 antibody tests, to see what results you get on a second run, and make sure he/she adds the following:

endomysial antibody (EmA) test (the one referred to in that article I gave you the URL to above)


and, I THINK, but am not sure, you will want these, too...

Transglutaminase Antibody, IgA
Transglutaminase Antibody, IgG

OK...that's about all I know to tell you.
I sure hope that was helpful - I know others on here know loads more than I do...but, that's a good start for you, at least...

I do not know a lot about all of the blood tests that can be run because, as you will see from my 'signature,' my diagnosis came about with ONLY the
Gliadin Antibody, IgA and IgG blood tests, even though I had an endoscopy that showed 'no current damage,' because I had already gone gluten-free and I had a very positive response to it, and I had already tested positive for one of the genes related to celiac disease. My doc gave me a "celiac disease" diagnosis based on all of that info, and on my Enterolab results showing a positive Gluten Sensitivity Stool Test, and a positive Stool Test for Autoimmune Reaction to Tissue Transglutaminase [Fecal Antitissue Transglutaminase IgA, versus a blood test for that, which I think you should get done, for both IgA and IgG, as I listed above].

Well - I imagine that others will chime in now - especially to help clarify what blood tests you'll want.

BEST WISHES!,
Gina
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"Get busy living
or get busy dying."


From: The Shawshank Redemption
--------------------------------------------------------------
gluten-free since Jan 1 '05
Positive response to diet within days, felt 'alive again' within 2 weeks

Feb 22 '05:
Diagnosed "Celiac Sprue, and IBS" by a GI doc, Dr. David Lin of Danville, CA
via blood testing 53 days after I began the gluten-free diet on my own:
Test results at 53 days POST going gluten-free were:

Gliadin AB IgA = 29.9
Since 30+ = positive for Celiac Disease when ingesting gluten, my doc
diagnosed me with Celiac Sprue then and there.

Gliadin AB IgG was 5.6 at that point
-------------------------------------------
Endoscopy with biopsies, AND colonoscopy with biopsies were done,
only to rule out other possible GI problems (especially intestinal
lymphoma) - My doctor told me the results indicated "no current damage
found" - and that as long as I stay gluten-free, I don't need another
biopsy for ten years.

Follow-up blood testing was done about one year later, by the same
Gastro doc, in Nov '05:
Gliadin AB IgA =26, Gliadin AB IgG <1

Blood testing done again by him, 5 months later (March '06)
He then told me my tests results were back to normal, and "Keep up the
good work! You can't argue with success!" :-)

I now see him one time per year for routine testing to make sure I am
staying gluten-free.
------------------------------------------------------------------------------------------
ADDTIONALLY:
I was also diagnosed as positive for antibodies and autoimmune
response to gliadin by Enterolab, via stool specimen taken 56 days
gluten-free

and I have one of the two genes that 'cause' Celiac Disease:

"HLA-DQ8," via Enterolabs cheek cell test kit
---------------------------------------------------------------------
I began a COMPLETE 'Gluten-free Casein-free' diet in Nov '05, due to:
"positive" for casein antibodies from Enterolab (in Feb '05)
and
"positive" for casein IgG (Elisa) via York Labs' finger-prick blood
test, Sept '05
and continued 'stomach pains,' although nothing compared to before
going gluten-free....

UPDATE: ALL remaining symptoms disappeared within weeks of going gluten-free&CF!
**********************

My PAST illnesses I believe are attributable to Untreated Celiac Disease:

Recurrent ear and throat infections in childhood
Frequent childhood stomach aches, underweight, picky eater
Tooth enamel problems/excessive cavities in childhood
Diagnosed in 20's with non-allergic rhinitis
Two spontaneous abortions (childless)
IBS diagnosis at age 28 (all better post going gluten-free and casein-free)
["Horrible" digestive problems from ages 32-47 - excess gas,
diarrhea gone post gluten-free!]
Reflux diagnosis at age 35 ('reflux' gone post gluten-free)
ADHD diagnosis at age 38 and at age 48 (not as bad with Gluten-free Casein-free diet)
Broke elbow in 2 places, age 39
Osteopenia diagnosed at age 44 (bone scan revealed thinning of spine -
taking Calcium and Vit D now)
Fibromyalgia diagnosis at age 40 (fatigue and pain all gone post gluten-free!)
Minor depression with anxiety diagnosed at age 42 (taking Paxil)
Skin cancer - squamous at age 43 and pre-melanoma at age 45
Adult acne (this, too, went away, but only after going dairy-free)
Topical dermatitis (so bad I needed steroid shots) diagnosed at age 46
(That's gone now, too!)
Excessive bruising of skin began at age 45:
I was told by derm doc AND family physician "That's just thin, aging
skin, nothing you can do about that" (GUESS WHAT?! ...NO unusual
bruising POST going gluten-free! I can now wear skirts and shorts
again!)


SO many years of being sick...
Hopefully, others will benefit from Science, and the increasing media
attention being given to Celiac Disease and gluten-based illnesses,
and will not have to go through what I, and others on here, have had
to go through.

#3 flo127

 
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Posted 13 October 2005 - 08:04 AM

Hi.

I am surprised no one else has answered this post yet...

I will try to help, but I tend to shy-away from this type of question, as others on here seem to be more up on this blood-test stuff, or have the info more readily at hand to share it...

Anyway...Let's see...your results were:

Gliadin Ab.,IgA 33.9 EU Limits<25.0
and the lab your doc used stated that "Equivocal" for them is within this range: (25.1-49.9)

Well...when they say 'equivocal' it pretty-much means 'probable weak positive' versus 'definite positive,' meaning they cannot clearly 'call it positive'...

BUT, the facts that you already 'have' Type I diabetes AND thyroid problems are big red flags for Celiac, when you coupled them with a weak positive IgA (as IgA antibodies more specific to Celiac than IgG).

I am not sure if other illnesses can cause your "anti-gliadin IgA" result to be elevated...That's the IgA you were tested for, btw (if you were told you got tested for Celiac disease)- it's a test for the anti-body levels in your blood against gliadin, the protein that causes the immune system to attack the villi in Celiacs, as it tries to attack the gliadin (mistakenly thinking it is a virus).

Well....Nov 8th is not too far away, and it's good that you did not have to 'fight' to get to see a GI doc, like some people have to. I hate when I read that...

Anway, your Gastro will most probably want to do an endoscopy w/biopsies, because most of them want to, since it is still considered to be 'what is expected of them by their peers,' so do NOT stop ingesting gluten - but, also do not go 'hog-wild, either...just eat some every day beforehand.

AND, be sure you print out the following article for your GI!:

Gluten-Free Diet Recommended for Patients with Serum IgA Endomysial Antibodies but Normal Duodenal Villi Biopsy, because he/she may just skip the endoscopy altogether!

I found it on a page at this site, actually, at:

http://www.celiac.co...-59105052178.77

Also, ask him/her to rerun those 2 antibody tests, to see what results you get on a second run, and make sure he/she adds the following:

endomysial antibody (EmA) test  (the one referred to in that article I gave you the URL to above)


and,  I THINK, but am not sure, you will want these, too...

Transglutaminase Antibody, IgA
Transglutaminase Antibody, IgG

OK...that's about all I know to tell you.
I sure hope that was helpful - I know others on here know loads more than I do...but, that's a good start for you, at least...

I do not know a lot about all of the blood tests that can be run because, as you will see from my 'signature,' my diagnosis came about with ONLY the
Gliadin Antibody, IgA and IgG blood tests, even though I had an endoscopy that showed 'no current damage,' because I had already gone gluten-free and I had a very positive response to it, and I had already tested positive for one of the genes related to celiac disease. My doc gave me a "celiac disease" diagnosis based on all of that info, and on my Enterolab results showing a positive Gluten Sensitivity Stool Test, and a positive Stool Test for Autoimmune Reaction to Tissue Transglutaminase [Fecal Antitissue Transglutaminase IgA, versus a blood test for that, which I think you should get done, for both IgA and IgG, as I listed above].

Well - I imagine that others will chime in now - especially to help clarify what blood tests you'll want.

BEST WISHES!,
Gina

<{POST_SNAPBACK}>


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#4 flo127

 
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Posted 13 October 2005 - 08:27 AM

Gina,

Thank you for responding to my post. As you can see, I am having some difficulty replying! I will suggest that the gastro run a full celiac panel as well as perform an endoscopy. A full panel should cover all the bases as far as the blood work goes.

I consider myself quite fortunate that I have a great endo who takes me seriously when I mention my health concerns. If I had to rely on my family Dr. I would still be fighting just to have celiac considered.

Once again thanks for the feedback!

Flo
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#5 FaithInScienceToo

 
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Posted 13 October 2005 - 09:36 AM

Hi, Flo -

I see you have yet to 'master' the 2 reply option buttons ;-)
That happens a lot...

If you want to use part of another's reply, use the 'reply' button that has the little quote marks on it - and it you want to delete part of that info, just go into that and edit it out, after you click on the ["reply] button...

For instance, in your first repply to me, you obviously used the ["reply] button that appears right after my post, instead of the [add reply] button, at the end of your thread...

If you had wanted to quote only a portion of my reply, you first need to quote all of it, via that ["reply] button, and then move your cursor and highlight the parts you want deleted out...

Try it with this reply from me...use the ["reply] button, and then edit out everything except this one sentence - IF you want to practice ;-)

Anyway, glad that you are happy with your GI!

Tag on to this thread when you get your results, OK?
It'll be good to find out what you learn.
I'll track this thread now -

Best wishes,
Gina
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#6 flo127

 
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Posted 08 November 2005 - 06:23 PM

I just want to post an update. I met today with the Physcians assistant at the gastro's office. After talking with and examining me she recommended I have an endoscopy and a colonoscopy. She also ordered the tissue transglutaminase test. I went and had the blood drawn today so, as soon as I have the results back I will post them here. Unfortunately, the soonest I can get in for the endoscopy and colonoscopy is December 14th. Also, the impression I got was that she was not thoroughly convinced that I had celiac disease. I think she is leaning more towards "delayed gastric emptying" or gastropareisis diagnosis. Anyway, I will continue to keep you updated.

Flo127
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