Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Blood Test Results - 2 Weeks In To Gluten Challenge
0

7 posts in this topic

Hi all,

 

As I mentioned in a thread a few weeks ago, I've recently started a gluten challenge after 3 years of very strict gluten free eating. 

 

I've got a biopsy in 2 weeks time (after which I will have been eating gluten for 5 weeks and 2 days in total - I've been eating around 6 slices of bread per day or equivalent).

 

2 weeks into the gluten challenge I had blood tests done.

 

Deamidated Gliadin IgA        * 99  U/mL    ( <15 )

Deamidated Gliadin IgG          <1  U/mL    ( <15 )

Tissue Transglutaminase IgA     <1  U/mL    ( <15 )

Tissue Transglutaminase IgG     <1  U/mL    ( <15 )

 

My results from 2010 are as follows (following many years of low gluten, but not gluten free eating):

 

Gliadin IgA Abs               * 47  U/mL    ( 0 - 20 )

tTG IgA/IgG                   * 52  U/mL    ( 0 - 20 )

 

When I had a biopsy in 2010, there wasn't any sign of Villous atrophy.

 

I was wondering after my latest blood test if I might be going for a biopsy too soon?

 

I understand that the 99 U/mL result for Gliadin IgA suggests that there's something going on, but am I understanding correctly that the other results (the IgG and the tissue results) suggest that there's no sign of damage being done?

 

Again, whatever the result I will be going back to strict gluten free eating. I'm definitely intolerant to the stuff. 

 

Thanks...!

0

Share this post


Link to post
Share on other sites


Ads by Google:

I think thats a very short challange for a biopsi? Sins you have been glutenfree for some time, it will take a while to get your gutts nice and damaged... If you want to be sure the test result is as accurat as posible, you should probably put the biopsi of for a bit.

 

Me, I'v been eating very little gluten for many years, but not been glutenfree. I did a blodtest (that wasen't planed), came back with DGP IgG of 9, when <7 is normal and >10 is positive. After two weeks of not very heavy challange, about 3 slices of bread a day, it came back 10. So doctor orderd biopsy, and I was told to eat 'normaly' (3 bread based meals a day and some pasta etc several times a week) for AT LEAST two months prior to the biopsy. And I have not been glutenfree, just glutenfree lightat best.

0

Share this post


Link to post
Share on other sites

I can't remember why you are doing a biopsy...You had a positive AGA IgA, which means a gliadin/gluten intolerance; and a positive tTG IgA, which means your body is making autoantibodies against the mucosal lining of your small intestine - so damage was being attempted; and you had a very positive result to the gluten-free diet. Did some other health issues come up so that you need to revisit the fact that you most likely are a celiac (of whom doctors missed the damage)?

 

Now you also have a positive DGP IgA  after only 2 weeks of gluten - pretty impressive by the way because many people need two months in order make enough DGP antibodies to register on tests. Your other tests were negative at 2 weeks, but that is quite the norm.  Not many people have so many positive celiac tests; most only have one or two.  The only one you are missing is the EMA IgA but that only shows up after advanced damage has happened and will definitely need more than 2 weeks to raise it.... Not that you'd want to.  ;)

 

Anyway, back to your question... Many doctors only require a two week gluten challeng for a biopsy so 4 weeks will probably be enough. If you want to be sure, you could delay it for another month and that should be enough time to do plenty of damage to yourself (these tests are quite barbaric). If the challenge is getting too difficult, then do it after the four weeks. you don't want to make yourself too sick. There are a few board members around here who did gluten challenges but they set themselves back many many months and more than one member apparently ("coincidentally") set off a permenent health problem. It's good to have a diagnosis but not if you are going to make yourself have longterm problems.  KWIM?

 

Good luck with that biopsy.  :)

2

Share this post


Link to post
Share on other sites
Thanks Nicole.
 
I didn't specifically get any more health issues come up, but I went back to speak to my doctor as I still get "IBS" symptoms when I deviate from my diet (my normal diet is somewhere between gluten free with some gluten-free grains and paleo. I avoid dairy most of the time and try to avoid all grains where possible). 
 
I often have issues when I eat out at restaurants (even when being careful that what I'm eating is gluten free). I can get gas, having to make a dash for the bathroom and even fatigue and a headache thrown in for good measure the next day! I am assuming that there is either cross contamination occurring, leaky gut, intolerance to soy, preservatives, processed oils etc. or something else happening.
 
When I spoke to the doctor about these continuing "IBS" symptoms, he explained that it would be an idea to re-check for celiac disease because the biopsy is the gold standard. I also understood from the consultation that if I have a definite celiac diagnosis then my health might be monitored more closely in the future for any related conditions. 
 
Anyway, now that I have done more research (and this forum has been really helpful) I might have decided again the gluten challenge if I was making the decision again right now. But I'm so close to the biopsy now that I'll carry on. I don't think I'll delay it ... I want to get back to feeling well again :)
 
I'm considering doing an elimination diet like Whole30 and/or seeing a dietician once I'm done with the challenge. 
 
Thanks again.
0

Share this post


Link to post
Share on other sites

Understandable. After putting in so much time on the gluten challenge, I would probably continue through with it too.

 

Dairy is a good first food to eliminate for celiacs. Because the intestinal area attacked is where lactase is made, many celiacs are lactose intolerant for 6 months until they heal, sometimes much longer.

 

A food journal is helpful when trying to figure out sensistivities, as is posting your diet here. The people around here helped me figure out that apples and pears cause me some gas issues and bloating - I never would have figured that one out on my own.

 

Good luck.  :) Let us know how it goes.

0

Share this post


Link to post
Share on other sites




It's been quite a while since my last update. I did in fact finish my gluten challenge and had a biopsy in September 2013. 

 

The outcome of my "gluten challenge" last year was a negative biopsy. The gastroenterologist who I was referred to came to the conclusion (despite the blood tests and symptoms) that I don't have coeliac disease and that it's okay for me to continue to eat gluten.

 

In a way it was disappointing as I (and others) think that I do have celiac disease and I believe other doctors would give me a positive diagnosis on the blood work and symptoms. 

 

Obviously I returned to a gluten free diet (I think this is especially important as there are other autoimmune issues in my immediate family).

 

And on to my family... unfortunately my brother who has terrible "gastrointestinal symptoms" at times (to put it politely) still refuses to get tested for coeliac. My elderly mother has quite advanced MS and other issues so even if she were tested and it were a positive result, I doubt she would be able to change her diet. 

 

My only concern for myself in the future is that Coeliac Australia state that any future vaccine which might be developed will only be available to those who have been diagnosed with a biopsy. Also my doctor mentioned that they wouldn't be as concerned with screening for other associated conditions in the future without the positive biopsy / diagnosis. 

 

Whatever happens, the gluten-free diet is for life for me. 

 

Anyway, that's the end of my very late update - thanks for listening and the advice :-)

0

Share this post


Link to post
Share on other sites

I'm glad you are doing so well!  :)

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,634
    • Total Posts
      921,525
  • Topics

  • Posts

    • I've been diagnosed with celiac a few months ago I thought that I had it for a while now it runs in the family.  I found out I had it a few months back when I ate chick fi a sandwich and had to go to the ER because I couldn't stop throwing up. They didn't know what it was and it took a few more months for anyone to take me seriously and find out what's wrong   Anyways I've gone gluten free now and I still have pains whenever I eat ANYTHING. It's cramping and burning and feels like my stomach is on fire.  I also have pains...below which I'm not sure what it is.  I ate a salad today, and now i'm in pain the salad had cheese, onion on it no dressing or any breading... Maybe I should stay away from cheese, I think it may be lactose and can't eat soy.   I ate some gluten free chex the other day with rice milk and ended up in pain.. I don't know maybe it's more than just celiac. I don't know if this is normal for people just going gluten free...maybe there was some hidden gluten in those foods. I don't know.   All i know is that this pain is hurting me and I'm tired. Thanks for reading...this is my first post.
    • I found my gas issues were caused by carbs, and sugars, something about how the bacteria in my gut changed and started making me gassy and extremely bloated when they got a hold of any thing more then a tbsp of grains, beans, fruit, or starch carbs. And no amount of medicine helped. Changed to 1/4 servings of those and mostly protein, fat diet. As for vitamin supplements I found I have to take B vitamin supplements 3 times a day to not go zombie mode. I personally found Liquid Vitamins Energy & Stress and the Nero-logic from them helps along with the occasional 1/2 bottle of 5 hour. As to carbonated water I avoided it when bloated cause it made me feel worse.
    • Butterbean, do go have a read of the dermatitis herpetiformis section.  See if anyone's story sound familiar to what you're experiencing.
    • Hi all. Well, it's been around twenty days since I've been taking Gas-X like meds (with simethicone), but no relief. Maybe I should drink bigger dose... Currently, I'm taking 80 mg four times per day.
      I'm so exhausted, both mentally and physically... Anyway, I have two questions:
      First, is it good or bad to drink mineral/carbonated water if you have severe trapped gas like me?
      Second: Is it possible to regain some physical strength/relieve fatigue with vitamin supplements? Thanks in advance.
    • I have had so many issues with my teeth--I keep getting decay and I have had filling after filling.  This past week, my dentist told me I may need a crown, which is pricey. I also have two missing teeth, which was a genetic thing that runs in my family. I am sick of hygienists telling me I am not doing enough brushing, flossing rinsing.  I do all three religiously (can't even imagine how bad my mouth would be if I didn't...)  Thankfully, last time I had my teeth cleaned, the hygienist said that my mouth was the cleanest one she had seen in years. And, she said, "something happened to your teeth developmentally." I explained how I had undiagnosed celiac disease many years. I am only 31... It is really disheartening.   What do you guys do to afford all this dental care?  My insurance doesn't cover a whole lot.  Thankfully, my dentist has felt bad and gives me discounts here and there.
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,637
    • Most Online
      3,093

    Newest Member
    Gracey
    Joined