Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Interpreting First Coeliac Serology Results
0

9 posts in this topic

Hi all,
 

I had some bloodwork done and I'm a little confused by the results as I haven't yet seen my GP for him to explain them to me. The tests read like this:

Anti TTG (IgA) Tissue Transgl. 128.000u/mL (0 - 6)

IgA Coeliac 1.510g/L (0.8-3.7)

Am I right in thinking the first test indicates coeliac disease, as what I've found online seems to indicate 10+ u/mL as positive? 128 seems really high in comparison! I have no idea what the second line means. Are the values in brackets the expected/normal/healthy ranges?

What is the possible Anti TTG (IgA) range for someone with coeliac disease - as I said, 128 seems crazy when 10 is a positive result.

So confused, why do all the antibodies etc have to sound so similar?!
Thanks in advance.







 

0

Share this post


Link to post
Share on other sites


Ads by Google:

The numbers in brackets are the ranges.  The TTG is positive, If the " IgA coeliac " test is actually the EMA IgA total serum then that is normal showing the TTG could be a false positive.  You really need to review them with your Doctor who can take the blood tests, any symptoms and your history all into consideration. 

 

All the best.

 

Colleen

0

Share this post


Link to post
Share on other sites

Thanks Colleen! I thought the TTG was positive but yeah, it's the IgA that's confusing. Seeing the doc on Friday but just trying to do my homework as it's a locum...

0

Share this post


Link to post
Share on other sites

I would have guessed the IgA coeliac was the total serum IgA, which is a control test to make sure you make enough IgA for your IgA tests to be accurate - you'd want it right in the middle of the range and it is. I don't remember the units but these look different than what I'm used to. Is this in the UK?

 

The EMA IgA is usually done as a ratio... I forget the correct term. When I had a positive EMA it was written as 1:40 without any units.

 

Anyway, your tTG iGA was very positive. Are you going gluten-free now or are they doing a biopsy on you first?  Either way, welcome to the club and I hope you feel better soon.

1

Share this post


Link to post
Share on other sites

Thanks Nicole! Yes, I'm in the UK which has made understanding the results a bit trickier as most of the information covers the tests done in the US, they seem to be slightly different.
 

I'm having another blood test on Friday - celiac panel maybe? - as my first tests were done at home (England) and I'm now back at university in Scotland and the NHS doesn't share info across the border. When I got my first results back in mid Sept I cut out gluten straight away as I needed all the help I could get for an upcoming marathon (26.2 miles with the runs = not fun). I started eating it again yesterday, so hopefully the two weeks off won't affect the results too much. I'm not keen on the biopsy just yet as it's my final year of uni so I just want to feel better and not mess around with hospitals - I'll probably have it done in a year or so when I have time to feel crap for three months... I just wanted more clarification from the bloods, partly to help 'convince' family and flatmates to take it seriously!

Is there any level of anti TTG IgA where coeliac is pretty much certain and a biopsy might not be so necessary? I read that this was suggested as 100 in kids?

Thank you :)

0

Share this post


Link to post
Share on other sites




Because the TTG IgA can also point to other autoimmune diseases, the Doctor will take all tests into account to determine Celiac Disease.  The Doctor can make a differential diagnosis of Celiac and not go forward with the Endoscopy if he believes there are no other issues to consider.  This is completely up to the Doctor. 

 

Good Luck,

 

Colleen

0

Share this post


Link to post
Share on other sites

At the ICDS, the doctors were saying that a TTG of over 100 means Celiac.  I guess it doesn't get that high with other diseases.  They still want to biopsy, especially adults or patients they think might have other issues.  They can do a colonoscopy at the same time and rule out a lot of additional problems.  The endoscopy isn't an operation.  It takes, at most,  a day of your life. 

 

Keep eating gluten.  If you were only off for 2 weeks, and your TTG was that high, you should be good.  The doctors at the ICDS did a study about Celiacs eating gluten.  They fed Celiacs who had gotten their TTG back to normal gluten for 2 weeks.  At 2 weeks the TTG wasn't positive but 2 (I think 2, might have been 4) weeks later, after stopping the gluten, it was positive.  It takes a while for us to stop making it.

1

Share this post


Link to post
Share on other sites

I was going to say something along the same lines. It is usually the weak positives that can be sometimes be caused by things like diabetes, crohn's, colitis, liver disease or thyroiditis. Your result is about 22 times the upper normal limit. It would be pretty safe to say celiac is the cause.

I hope you feel better soon.

0

Share this post


Link to post
Share on other sites

Thanks everyone. My family and friends don't really get it yet so this post has stopped me running off to the only person I know with coeliac disease - my ex boyfriend! Not who you want to discuss your insides with ;)

 

My test on Friday is a full blood count so presumably that will clarify things a bit further. If I still want a biopsy that's a 3-4 month wait... My liver, kidney and thyroid functions have already been checked and I don't have the symptoms for Crohn's or colitis. In fact I have hardly any at all (a tiny bit of bloating and cramps and marginal anaemia) which is good in a practical sense but also scary that my immune system has (probably) been secretly been munching on my intestines!

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,688
    • Total Posts
      921,755
  • Topics

  • Posts

    • Yeah I ended up allergic to corn, olives, sesame, whey, and peanuts and intolerant to dairy, soy, yeast, enzyme issues with breaking down meats, and egg yolks, along with extreme bloat with any kind of carbs/sugars in moderate amounts. And very adverse reactions to certain artificial sweeteners. So your not alone in all the other issues cropping up, it happens as our bodies adjust.  I eat a bunch of stir frys with veggies, egg whites, plenty of  avocados, and toasted and raw forms of almonds, coconut, cashews, walnuts, hemp seeds, pumpkin seeds, flax seeds, sancha inchi seeds, chia seeds, and sunflower seeds in all forms including making them into butters, spreads, and incorporating them into sauces.   Most meals are forms of soups, omelettes, and stir frys. I do the seeds and nuts on rotation same with my veggies and snack on fruits in small amounts along with some homemade baked goods I make for markets. I do suggest a rotation of foods, my dietician said I need to rotate my foods to prevent more issues, making sure I am off one one for at least 7-14 days at a time completely. I find changing up the spices and rotating my cuisine base works well. I also make puddings, and protein shakes along with nut/seed milks, and different bases and extract flavorings to get my random cravings Taken care of. Guess take what you can from this and and see how it can help you,    As to the tinging, I ended up with both B vitamin and magnesium deficiency issues, the magnesium one caused a fire like tingling in my arms, legs and back, along with muscle pain. Ended up on a doctors best powder form of it so I can dose it out right, and found epsom salt bathes helped.  
    • Hi, I've gained so much knowledge on this forum over the past few months, which I am so thankful for. I can see how much hell people are going through with this disease and it's so lovely to see how much support and advice people give to others on here. I'd like a little bit of reassurance and advice myself from anyone that can help. I've been gluten free for six months. Two weeks after going gluten free I realised I also had a problem with corn so cut out processed food. Over the following weeks and months I continually had problems with food; fruit, dairy, a lot of vegetables, nuts, soya....it's basically dwindled down to just eating potatoes (not white potatoes), cucumber, lettuce, small amounts of red onion, spring onion, sprouts and beetroot. There may be more things I could be okay with but to be honest I'm too scared to try.  Is this all normal? Am I an extreme case? I've been taking some digestive enzymes and probiotics for about six weeks, my acid reflux has dramatically decreased but I always have a lot of loud noises going on in my guts, I'm guessing this is the probiotics working.  I've lost nearly 3st in weight since this started - which I'm not complaining about as I was overweight due to thyroid problems. I've had loads of blood tests done recently, all organs are working 'great' according to my doctor, the only thing they've picked up on is ketones, I seem to be having a glucose problem, which might explain my exhaustion and weight loss. I also have permanent numbness and sometimes tingling in one of my legs and sometimes hands and one shoulder, I thought it could have vitamin B12 deficiency but that's okay according to blood tests. I would be greatful for any replies. Thanks for reading.
    • Hi everyone, I am doing job in restaurant at evening 5 to 12 during working hours no time to do a dinner. I'm thinking to make a shake but don't know the gluten free vitamin or supplement brand which one is good for me and easily available in Berlin Germany to make me fit cause last one week i feel weak. I'm 28 year old. Sincerely
    • Hey there just wanted to warn anyone that has other allergies- these crackers may not be a good choice! I'm mildly sensitive to MSG- I only react if there's a giant amount like in Chinese food or Ramen noodles, etc.  I literally have a to eat TONS of a the offending food before reacting.  Anyway, I was excited to try these Trader Joes pumpkin crackers, kept hearing about them on the radio .... and they're gluten free!  (I have Hashi's).  I ate about 3/4 of the box last night. Woke up this morning with a red itchy face and nasal congestion, headache, anxiety. Hallmark symptoms for me of high MSG intake. (It does say yeast extract on the side but it's pretty far down the list). So if you're sensitive.... stay away! Apparently these particular crackers are loaded with it. 
    • I admit, my blood panel was "mildly positive" with only the DPG IGA being the positive, yet I had a Marsh Stage IIIB (pathologist report) though my visual on the endoscopy was fine.  celiac disease can be hard to diagnose, that is for sure.  
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

    There are no registered users currently online

  • Member Statistics

    • Total Members
      61,688
    • Most Online
      3,093

    Newest Member
    AbuBakar
    Joined