Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Help With Blood Work
0

6 posts in this topic

Hello,

Last week we had our 2 year old sons blood tested for a bunch of allergies.  His symptoms have been ongoing and never changing diarrhea since birth.  At every new stage of new milk or formula Dr would say oh its just the change it will get better. Well it never did and so I brought him to a Pediatric GI.  He also has an unexplained eczema that he has had also since he was a newborn.  The test results are negative for Celiac but I would like your opinion.......also he was negative for the long list of food allergies that they tested for.

 

Here are his results.

IgA 58. Range is 11-134

IgA1 53. Range is 7-132

IgA2 6. Range is 1-23

 

IgE is 28. Range <61.

 

tTG Negative

tTG antibody IgA was 3.10. Range is <20.

 

Thank you everyone for your help.  I know that he can test negative and then we have an endoscopy done and they find that he does indeed have Celiac.  

 

0

Share this post


Link to post
Share on other sites


Ads by Google:

IgE looks normal so it doesn't look like an allergy (as far as I know).

 

I'm not sure what the three types of IgA testing were for. I've never seen that done. He does appear to make adequate levels of IgA though so his tTG IgA should be fairly accurate... as accurate as it can be in toddler.  His tTG IgA is negative but those tests do tend to miss celiacs who are toddlers more often than adults.  The tTG IgA is 75-95% sensitive so there is a 5-25% chance his test is a false negative - probaby closer to the lower end because his IgA levels are adequate. This report discusses it on page 10-12: http://www.worldgastroenterology.org/assets/export/userfiles/2012_Celiac%20Disease_long_FINAL.pdf

 

As you pointed out, he could still have celiac disease in spite of the negative test. Are the other tests available to him? This is the full panel:

tTG IgA and tTG IgG

DGP iGA and DGP IgG (best test for children)

EMA IgA (detects more advanced cases)

AGA IgA and AGA IgG (older and less reliable test thought by some to also show non-celiac gluten intolerance - NCGI)

 

The DGP test might show you something, or even the IgG based tests...

 

There is also the chance that he has NCGI in which case he will have all the same horrible symptoms of celiac disease but not the villi damage (the blood tests look for autoantibodies that cause the villi damage). All you can really do is go gluten-free to test that theory- once all other testing is done.

 

My boys all had negative tTG igA tests, which were the only tests available to us, but I am a celiac and 2/3 of my kids had symptoms so I made them all gluten-free, and they are all much healthier because of it. You may have to go gluten-free without a doctors order; if you do, give the gluten-free diet at least 3 months before you judge it's effectiveness as healing takes time.

 

Good luck in what ever you decide to do.

0

Share this post


Link to post
Share on other sites

just copying and pasting what I wrote in your other post :)

 

this link helped me learn about the different types of blood immunoglobulins when I first started researching: http://kidshealth.or...oglobulins.html

 

the following tests are not diagnostic of celiac, but instead tell you that your son makes normal levels of IgA and IgE.

 

Here are his results.
IgA 58. Range is 11-134
IgA1 53. Range is 7-132
IgA2 6. Range is 1-23

IgE is 28. Range <61.

 

The only celiac test that was completed was:

 

tTG Negative
tTG antibody IgA was 3.10. Range is <20.

 

Even though your son produces a normal amount of IgA and his TTG is negative, he really should have the DGP IgA and IgG based tests performed because they can be more helpful in finding celiac diesease in young children. 

 

take a look at the last line in this link: http://www.curecelia...-celiac-disease

 

take a look at this abstract as well regarding DGP to young children:  http://www.ncbi.nlm....pubmed/23558824

 

I'd say before moving onto the endoscopy, see if you can get the doctor to run the deamidated gliadin peptide IgA and IgG versions. 

 

good luck!

0

Share this post


Link to post
Share on other sites

I agree, Nicole.  I did some searching, and here was the best explanation I could find:

 

IgA Subclasses IgA1

IgA1 comprises approximately 85% of total IgA concentration in serum. Although IgA1 shows a broad resistance against several proteases, there are some that can affect / splice on the hinge region. IgA1 shows a good immune response to protein antigens and, to a lesser degree, to polysaccharide and lipopolysaccharides.

IgA2

IgA2, representing only up to 15% of total IgA in serum, plays a crucial role in the mucosa of the airways, eyes, and the gastrointestinal tract to fight against polysaccharide and lipopolysaccaride antigens. It also shows good resistance to proteolysis and many bacterial proteases, supporting the importance of IgA2 in fighting bacterial infections.

 

 


I'm not sure what the three types of IgA testing were for. I've never seen that done.


 

0

Share this post


Link to post
Share on other sites

Awesome! Thank you all so much! I will bring it up to the dr that I don't believe the full blood panel was done.

I was confused for sure and thought the iGA1 was apart of celiac panel.

0

Share this post


Link to post
Share on other sites




Awesome! Thank you all so much! I will bring it up to the dr that I don't believe the full blood panel was done.

I was confused for sure and thought the iGA1 was apart of celiac panel.

 

The total serum IgA is run because about 5% of celiacs are deficient in IgA (which is higher than the regular population) which means that any IgA based testing (tTG IgA, DGP IgA, EMA IgA) that is done will most likely yield a false negative result if the patient is in fact a celiac. Those low in IgA will need to rely on IgG based tests instead. I think it's a good idea to run those anyway as there are a few celiacs around here who were diagnosed with only positive IgG based tests.

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      103,635
    • Total Posts
      918,419
  • Topics

  • Posts

    • healthy bread recipe?
      Eat what you eat at lunch or dinner.  I am happy with a fried hamburger patty, fish, or chicken (I know it needs to be fresh or frozen for the histamine diet).  Yes, I eat veggies for breakfast!   Wanted to add that I was glutened in July (GI ordered follow-up antibodies testing and it was high)  and it took me 3 months to recover.  Picked up a histamine intolerance and became lactose intolerant again.  Luckily, when I healed, the histamine thing went away (or  Diminished ) and the lactose intolerance resolved.    I was getting hives, rashes and itching (not DH), vomiting, etc.  So, her intolerances may be just temorary!  
    • Could this be celiac or is it really just IBS?
      Are you sure you had the complete celiac panel?  Here are the tests:   -Tissue Transglutaminase (tTG) IgA and (tTG) IgG -Deamidated Gliadin Peptide (DGP) IgA and (DGP) IgG -EMA IgA  -total serum IgA and IgG (control test)     -endoscopic biopsy - make sure at least 6 samples are taken   VERY IMPORTANT:  Keep eating gluten daily until ALL testing is complete or the tests can be inaccurate.     (Source: NVSMOM -- 😊)   Here is more information from a reputable site (and not just info from a crazy cyclist on the Internet!):   http://www.cureceliacdisease.org/screening/   IBS, in my opinion, means "I Be Stumped!"  It is just a cop out!  So is the "stressed" thing.     I also had my GB out too.   It was a non-functioning (0% per HIDA scan), no stones, and rotting.     You seem to have many celiac disease symptoms.  Verify (obtain copies of your lab tests) to see if you got the complete panel. You might just have had the TTG IGA and TTG IGG tests.  Good for screening but it does not catch all celiacs.  My TTG tests are always negative even on follow-up testing.  The DGP test catches a positive for me.  My biopsies revealed moderate to severe damage.  If my celiac-savvy GI did not order the complete panel, my celiac disease diagnosis would never have been caught.   if celiac disease is really ruled out, research mast cell disorders.  The flushing and GI upset sound familiar!  You can have more than one thing going on!  But I would put my money on celiac disease!            
    • tightness in throat after eating gluten?
      I've noticed that if I accidentally eat gluten, for the next few days I have this tightness in my throat. It feels like my throat is closing. It's not constant, but comes and goes throughout the next 1-3 days. My hands have also been itchy. Is this a normal symptom for celiac or gluten intolerance, or could it possibly be an allergy? I haven't been tested or diagnosed with celiac or anything yet, so I'm still not entirely sure. All I know is that gluten makes me very sick.. But especially with the itchiness and tight throat.. I'm allergic to acetaminophen and my reaction is similar, so it just makes me wonder. What do you think?
    • Diagnosis and Test Results
      I am sorry that you are sick!  😔.  I think you need to find out which celiac antibody tests were given.  Often just the TTG Is ordered for initial screening.  This test catches most, but not all celiacs (like me!)   You also need to see if they gave you the igA deficency test too.   Here are the tests:   -Tissue Transglutaminase (tTG) IgA and (tTG) IgG -Deamidated Gliadin Peptide (DGP) IgA and (DGP) IgG -EMA IgA  -total serum IgA and IgG (control test)   -endoscopic biopsy - make sure at least 6 samples are taken   VERY IMPORTANT:  Keep eating gluten daily until ALL testing is complete or the tests can be inaccurate.     (Source: NVSMOM -- 😊)     http://www.cureceliacdisease.org/screening/ You can go gluten free, but knowing if you have an autoimmune disease is helpful.  celiac disease is genetic (you have the genes, but so does 30% of the population and that's why the gene test is used only to exclude celiac disease and not diagnose it).   All family members should be tested even if they are symptom free.   I hope you figure it out and I am sorry that you had such a horrible experience.  
    • amalgam dental fillings - remove or not?
      My friend, I'm sorry to hear of your pain. I don't know if mercury is related, but I will give you my brief experience. I went through so many health issues, medications, and dr's and nobody could find anything wrong with me, but I knew something was wrong. I've been through many doctors, shots, pills, etc and nothing helped. For me it all came down to gluten. I had blood tests that shown the antibodies and the endoscopy that proved I had celiac, which I don't think is needed. If your body makes the antibodies I can't help to believe you have it. Anyway, long story short. If you are sick, you are sick and if a doctor can't find the reason, move on to a new doctor. Celiac, at least for me was simple. Stop eating gluten and every other health problem goes away. I have 30 + year old amalgam fillings and I feel amazing as long as I don't put anything in my mouth that isn't naturally gluten free, which means I only eat meat and vegetables. Our bodies are all different. I guess my only advice to you is if you're sick, your sick. Nobody lives inside your body but you and you know best if you feel better. Don't be afraid to stand up for yourself. 
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

    • celiac sharon  »  cyclinglady

      Hello cycling lady, have you noticed my picture is showing up as you?  Have no idea why but it's rather disconcerting to see my picture and your words 😉  Do you know how to fix it?  You seem to have far more experience with this board than I do
      · 1 reply
    • Larry Gessner  »  cyclinglady

      Hi There, I don't know if there is a place for videos in the forum. I just watched "The Truth About Gluten" I think it is a good video. I would like to share it somewhere but don't know where it should go. Any help would be greatly appreciated.
      Here is the link if you have never watched it.
      https://youtu.be/IU6jVEwpjnE Thank You,
      Larry
      · 2 replies
    • ChiaChick  »  Peaceflower

      Hi Peaceflower, Just wanted to say thank you for the chat.
      · 0 replies
  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      60,726
    • Most Online
      1,763

    Newest Member
    bitsunderground
    Joined