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Blood Test Results - Aga Igg Positive
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Hi all,

 

I'm new here and would appreciate help with interpreting my blood test results.

 

TgA IgG - 0.160 (<1.000 negative)

TgA IgA - 2.69 (<20.00 negative)

 

AGA IgA - 17.12 (<25.00 negative)

AGA IgG - 39.50 (>25.00 positive)

 

I have many symptoms and they're actually getting worse with time. I did the tests 10 months ago on my own and my GP completely ignored it. I've been worse and worse and only recently decided to go completely gluten free as I can't cope with it anymore.

 

I had limited gluten consumption a few months before testing but was still having some every or almost every day. Unfortunately I wasn't tested for total IgA.

 

Thanks for any comments!

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Hi all,

 

I'm new here and would appreciate help with interpreting my blood test results.

 

TgA IgG - 0.160 (<1.000 negative)

TgA IgA - 2.69 (<20.00 negative)

 

AGA IgA - 17.12 (<25.00 negative)

AGA IgG - 39.50 (>25.00 positive)

 

I have many symptoms and they're actually getting worse with time. I did the tests 10 months ago on my own and my GP completely ignored it. I've been worse and worse and only recently decided to go completely gluten free as I can't cope with it anymore.

 

I had limited gluten consumption a few months before testing but was still having some every or almost every day. Unfortunately I wasn't tested for total IgA.

 

Thanks for any comments!

 

I don't have individual experience with the full panel, but have copy+pasted information from celiacdisease.about.com:

 

Definition:

The AGA-IgG blood test is one of a panel of five celiac disease blood tests used to screen for and diagnose celiac disease.

AGA stands for antigliadin antibodies, which are antibodies produced by the body in response to contact with gliadin, a part of the gluten molecule. IgG stands for immunoglobulin G, which are generalized antibody molecules.

A positive AGA-IgG blood test indicates that the body may be mounting an immune system response to gluten ingestion, but it's considered less specific than other celiac blood tests. However, a positive AGA-IgG test can indicate celiac disease in a patient with IgA deficiency.

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AGA IgG is a celiac test. It's just not used that often anymore because it is not a very sensitive, it can miss up to 83% of celiacs. It's specificity is between 85 and 95%, which means 85-95% of positive results are celiac disease.. If you manage to get a positive in that test, it's probably celiac disease. Not all celiac are positive in all celiac tests, I'm not even sure the majority do.

This report discuss the tests from pages 10-12:

http://www.worldgastroenterology.org/assets/export/userfiles/2012_Celiac%20Disease_long_FINAL.pdf

You could have more tests and hope to get more positives to back up your one positive result but I hope you'll go gluten-free at the end of it all. Yes it is a hassle at first, but it really is a treat to feel well.

Best wishes in whatever you decide to do.

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Thanks guys! I really appreciate your help.

I am gluten-free at the moment and feel better every day. I plan to do the DNA test to check if I have the gene and maybe see a good specialist after that

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Glad you are feeling better.  :)

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I have done the genetic test and I have the HLA-DQ8 gene.

Anytime I get glutened, I get seriously depressed. I even ended up crying at the dr's office a few days ago! It also turned out I've got underactive thyroid so obviously there's a possibility of hashimoto disease.

I think it's clear I'm celiac. I started a strict gluten-free diet after getting the dna result but will still look into seeing a specialist soon.

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